Clinical trials: sponsored by IRCCS Eugenio Medea
Cerebral Palsy
Transcranial Alternating Current Stimulation in Cerebral Palsy (BOOSTTACS)
The present study aims to assess, through a randomized controlled trial (RCT), the efficacy of transcranial alternating current stimulation (tACS) in enhancing the functional changes due to an intensive motor training in children…
- Trial name
- BOOSTTACS (NCT06372041)
- Testing
- transcranial Alternating Current Stimulation
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS Eugenio Medea
Epilepsy, Angelman Syndrome
Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy
Recent studies have shown that the aperiodic part of the signal (neuronal avalanches) of electroencephalography (EEG) contains important information about the dynamics of neuronal networks.
- Conditions
- Epilepsy, Angelman Syndrome, Dup15q Syndrome
- Trial name
- NCT06353620
- Testing
- High Density EEG recording, Rey Complex Figure Test
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Eugenio Medea
Neurodevelopmental Disorder (Diagnosis)
Optical Genome Mapping for the Diagnosis of Neurodevelopmental Disorders
to evaluate the ability of the Optical genome Mapping (OGM) approach to detect simple and complex constitutional chromosomal aberrations of clinical relevance, which had previously been identified with standard diagnostic…
- Trial name
- NCT06347562
- Testing
- Optical Genome Mapping
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- IRCCS Eugenio Medea
Caregiver Burden
Eye Movement Desensitization and Reprocessing Group Treatment for Caregivers of Pediatric Brain Tumor Patients
Caregivers of pediatric brain tumor survivors may develop high levels of psychological distress, mostly depression and anxiety, with effects comparable to those of a traumatic event.
- Trial name
- NCT06339814
- Testing
- Eye Movement Desensitization and Reprocessing Integrative Group Treatment Protocol, Treatment As Usual
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- IRCCS Eugenio Medea
Neurodevelopmental Disorders
Omic Approaches to Neurodevelopmental Disabilities
to bridge the gap between the molecular structure of CNV and the effect on the phenotype, considering NDDs as complex diseases, as they are a consequence of the imbalance in several dosage-sensitive genes, we might try to…
- Trial name
- NCT06337396
- Testing
- WGS and transcriptome analysis
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS Eugenio Medea
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
Motor Impairments in Children With Autism Spectrum Disorder: a Multimodal Approach
The general goal of the present proposal, Progetto MOSAICO, is the identification of a multimodal panel of neuropsychological, kinematic, neurophysiological, and genetic markers associated with motor abnormalities present in ASD.
- Conditions
- Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Intellectual Disability
- Trial name
- MOSAICO (NCT04769011)
- Testing
- Clinical evaluation, Neuropsychological evaluation, Neurophysiological evaluation
- Where
- Italy
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Glymphatic System, White Matter Disease
Evaluation of Brain Waste Clearance Pathways Using Magnetic Resonance Imaging in Pediatric Patients With White Matter Diseases
The dilation of perivascular spaces can be the result of various etiopathogenetic processes. White matter atrophy can cause enlargement of these perivascular spaces (PVS) but also obstruction of fluid drainage systems…
- Conditions
- Glymphatic System, White Matter Disease, Pediatric Disorder, Perivascular Disease
- Trial name
- NCT06335004
- Testing
- Magnetic resonance imaging
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea
Epilepsy
Observational Study of the Structural-functional Connectome in Patients With Epilepsy
Over the past decade, the concept of the brain as a complex network has extremely influenced the way regarding how the latter is studied (Bartolomei et al., 2017).
- Trial name
- NCT06334029
- Testing
- Functional and structural Connectome
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Eugenio Medea
Developmental Dyslexia, Developmental Spelling Disorder
Remotely Controlled Intervention for Developmental Reading and Spelling Disorders Through the Tachidino Platform
The study aims to document the effects of the intervention system for specific reading and spelling disorders, currently in use at Scientific Institute (IRCCS) Medea as an innovative intervention model in e-health mode.
- Trial name
- NCT04382482
- Testing
- Tachidino
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Eugenio Medea
Dyslexia, Developmental
Poly-unsaturated Fatty Acids and Developmental Dyslexia
Poly-unsaturated fatty acids (PUFAs) represent a component of lipids that covers a relevant role in human diet and biological functions such as provision of energy, functionality of cell membranes and tissue metabolism.
- Trial name
- NCT04287530
- Testing
- Poly-unsaturated fatty acids supplementation, Neuropsychological intervention
- Where
- 2 sites in Italy
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Developmental Psychological Disorder
Developmental Psychopathology and the Gene-environment Interaction
The present is a followup study that aims at investigating the effect of genetic and environmental factors on the possible development of psychopathological conditions in a longitudinal perspective.
- Trial name
- TwinAger (NCT04489069)
- Testing
- MRI, Clinical and Neuropsychological evaluations, Drawing DNA sample
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Acquired Brain Injury, Pragmatic Communication Disorder
Pragmatic Abilities in Children With Acquired Brain Injury
Although neuroplasticity of the brain is high in childhood, some neuropsychological sequelae could persist over the long term in children with Acquired Brain Injury (ABI).
- Trial name
- ABIabc (NCT04280978)
- Testing
- ABI ABC
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Acquired Brain Injury, Cerebral Palsy
Verify the Performance in Clinical Practice of the Immersive Virtual Reality Platform GRAIL (Gait Real-time Analysis Interactive Lab)
Gait pattern difficulties, balance and coordination deficits often characterize patients with congenital and acquired neuromotor disorders and have a significant impact on the quality of life of these subjects.
- Trial name
- NCT06317519
- Testing
- Physical Rehabilitation, Gait Real-time Analysis Interactive Lab
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea
Cerebral Palsy, Acquired Brain Injury
Assessment of the Psychophysical State During Rehabilitation Treatment With Lokomat
The use of robotic technologies in rehabilitation is an increasingly widespread practice in the health sector: the Lokomat is a medical device intended for walking rehabilitation, consisting of an exoskeleton, a treadmill and a…
- Conditions
- Cerebral Palsy, Acquired Brain Injury, Hereditary Spastic Paraplegia
- Trial name
- NCT05767268
- Testing
- Lokomat
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- IRCCS Eugenio Medea
Reading Disorder
Gene x Environment Interplay in Developmental Dyslexia Treatment: A Round-trip Translation Between Humans and Animal
Developmental dyslexia affects 7% of school-age children (Male:Female ratio of 1.5:1) and incurs disadvantages in education and occupation.
- Trial name
- Gedys (NCT06186882)
- Testing
- Action Video-Game
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Preterm Birth, Parent-Child Relations
Biological Underpinnings of Socio-emotional Regulation in Preterm Infants and Healthy Controls
Preterm infants (PT) often need to spend their first weeks of life in the Neonatal Intensive Care Unit (NICU) where they are exposed to several adverse conditions.
- Conditions
- Preterm Birth, Parent-Child Relations, Epigenetics
- Trial name
- NCT05253924
- Testing
- DNA methylation of target genes, EEG acquisition
- Where
- Italy
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Developmental Disability, Parent Child Relationship
Mother-Infant Interaction Kinect Analysis (MIIKA)
An innovative methodology is developed to better understand parent-infant relationships. RGB-D sensors (such as Microsoft Kinect) give us the opportunity of online skeleton extraction based on the joints architecture of human…
- Trial name
- MIIKA (NCT04288973)
- Testing
- Microsoft Kinect Detection during mother child interaction
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- IRCCS Eugenio Medea
Sotos Syndrome, Beckwith-Wiedemann Syndrome
Body Perception and Representation in Overgrowth Syndromes, Behavioral Assessment and Neuropsychological Development
Sotos Syndrome (SS) and Beckwith-Wiedemann Syndrome (BWS) are known as overgrowth syndromes as they involve an excessive growth of the whole body or of specific body parts.
- Conditions
- Sotos Syndrome, Beckwith-Wiedemann Syndrome, Overgrowth Syndrome, Body Image
- Trial name
- Body-PROBAND (NCT04993235)
- Testing
- NEPSY-II, CBCL and AQ questionnaires, BUT questionnaire and experimental tasks
- Where
- Italy
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Epigenomics, Developmental Disability
Early Parenting Intervention: Bio-behavioral Outcomes in Infants With Neurodevelopmental Disabilities
Infants with developmental disabilities present a high risk of behavioral and socio-emotional problems. Their parents are themselves at risk of developing emotional and affective disorders which can impact the quality of the…
- Conditions
- Epigenomics, Developmental Disability, Early Intervention, Parent-Child Relations
- Trial name
- EPI-BOND (NCT03853564)
- Testing
- Video-Feedback Intervention, Phone-Call Intervention
- Where
- 3 sites in Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS Eugenio Medea
Neurodevelopmental Disabilities, Emotional Regulation
Emotional Regulation in Children With ND: the Role of Genomic Variation, Proteomic Patterns, and Early Experience
Children with neurodevelopmental disabilities (ND) represent an heterogeneous population characterized by a wide range of clinical diagnoses (e.g., cerebral palsy, sensory impairment, psychomotor retardation), which are…
- Conditions
- Neurodevelopmental Disabilities, Emotional Regulation, Epigenetics, Parental Factors
- Trial name
- NCT05004090
- Testing
- DNA methylation analysis, Proteomics analysis, Still Face Paradigm
- Where
- Italy
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea