Clinical trials: sponsored by IRCCS San Raffaele
Eosinophilic Esophagitis
Prospective Registry of EoSinophilic esOphagitis
This is a prospective registry of all the Eosinophilic Esophagitis (EoE) patients referred to the third level referral centre of San Raffaele Scientific Institute
- Trial name
- PRESO (NCT06443346)
- Testing
- Eosinophilic Esophagitis
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Infertility (IVF Patients)
The Embryo-endometrium Multifaceted Interface: Endometrial Cavity Molecular Microbiobial and Transcriptomic Signatures in Predictinf Pregnancy Outcome in Infertile Patients Undergoing Assisted Reproduction Technology Procedures
In reproductive medicine, a fundamental challenge is to evaluate the endometrial health status during the embryo implantation window as a limiting step in predicting the success of treatments of assisted reproduction technology…
- Trial name
- NCT07085585
- Where
- Italy
- Volunteers
- 322 people
- Sponsor
- IRCCS San Raffaele
Quality of Life
Wine Implementation for Surgical Recovery Enhancement
This is a monocenter, prospective randomized clinical trial. The study aims to investigate whether moderate consumption of red wine (1 unit at lunch and 1 unit at dinner) for 30 days after surgery could improve the quality of…
- Trial name
- WISE (NCT05261620)
- Testing
- red wine
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Micro-ultrasound for Prostate Cancer Diagnosis
This is a single-center, paired-cohort, prospective study. Patients with a clinical suspicion of csPCa will receive mpMRI and Micro-US in two different visits.
- Trial name
- NCT04832997
- Testing
- Prostate biopsy systematic random prostate biopsy (TRUS-Bx) + eventual MRI-targeted biopsy (MRI-TBx) + eventual microUS-targeted (Micro-US-TBx)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele
Head and Neck Cancer
This Protocol Focuses on the Factors That Influence Survival, the Development of Complications and the Quality of Life Based on the Treatment Received in the Group of Patients Suffering From Malignant Lesions of the Head and Neck
This protocol focuses on a retrospective, single-center analysis, analyzing the factors that influence survival as the main objective, and secondarily the development of complications and the quality of life based on the…
- Trial name
- NCT07066878
- Testing
- treatment received in the group of patients suffering from malignant lesions of the head and neck.
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS San Raffaele
SAR-CoV-2, Cellular Immune Response
Study of Immune Response in Subjects Vaccinated Against SARS-CoV-2 Infection
Twelve months after the first SARS-CoV-2 cases in Wuhan, the FDA approved the first COVID-19 vaccine (Pfizer-BioNTech). Early studies on healthcare workers showed that antibody levels, especially against the Spike protein…
- Conditions
- SAR-CoV-2, Cellular Immune Response, Antibody Response
- Trial name
- BioVAC-immunit (NCT07049497)
- Testing
- Evaluation of the T cell response in terms of IFN-γ measured by ELISpot
- Where
- Italy
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pregnancy, Neurodevelopment
Maternal Risk, Fetal-Neonatal Brain Connectivity, and Early Neurodevelopment: A Longitudinal Observational Study
This study aims to understand how a pregnant woman's health, lifestyle, and psychological state-especially when associated with known risk factors-might influence the developing brain of her baby, both before and after birth.
- Conditions
- Pregnancy, Neurodevelopment, Brain Connectivity, Neurodevelopment Outcome
- Trial name
- MaMRI-NeUCogI (NCT07059286)
- Testing
- Maternal Frailty Inventory (MaFra) Questionnaire, Fetal Resting-State Functional MRI, Maternal Emotional Reactivity
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS San Raffaele
Primary Mediastinal Large B-cell Lymphoma (PMBCL)
Primary Mediastinal Large B-cell Lymphoma With CNS Involvement
This is a retrospective, multicenter study focused on patients with a known diagnosis of PMLBCL which experienced a CNS relapse during the course of their disease to obtain information about the clinical characteristics, the…
- Trial name
- NCT06024694
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele
Stroke Acute
Study of Inflammatory Cells in the Blood and Cerebral Thrombus of Patients Affected by Cerebral Ischemia
This is an observational, prospective and retrospective, single-center study of thrombotic material and blood samples obtained from patients undergoing mechanical endovascular thrombectomy for ischemic stroke caused by large…
- Trial name
- ClotBioInsight (NCT07033988)
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- IRCCS San Raffaele
Respiratory Disease, Cardiovascular Diseases
Prospective Observational Study to Characterize Patients Treated at Internal Medicine Clinics
Patients referred to internal medicine wards are becoming increasingly complex and fragile. Despite deep knowledge of their specific disorders, steps are required to improve overall management of their acute and chronic…
- Conditions
- Respiratory Disease, Cardiovascular Diseases, Infectious Disease, Critical Illness
- Trial name
- MED-Cli (NCT05780099)
- Testing
- Inpatient or Outpatient visit
- Where
- 2 sites in Italy
- Volunteers
- 50,000 people
- Sponsor
- IRCCS San Raffaele
Frailty, Sarcopenia
Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa
Observational study. Participants of the FRASNET study (9th March 2017, Protocol No. 24/INT/2017) who were evaluated in 2016 and 2017 will be contacted to be re-evaluated with multidimensional visits as part of the present study…
- Trial name
- AGE-IT-FRAILTY (NCT06324149)
- Testing
- completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogram; bioelectrical impedance analysis
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Preeclampsia, Immunologic Disease
Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome
The purpose of the study is to evaluate the ability of placental angiogenesis markers to predict the risk of PE in pregnancy in women with primary APS.
- Conditions
- Preeclampsia, Immunologic Disease, Antiphospholipid Antibody Syndrome Primary, Pregnancy Complications
- Trial name
- NCT05786235
- Testing
- Collection of epidemiological and anamnestic data and collection of biological material (peripheral blood)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Rheumatic Diseases, Fertility Disorders
Medically Assisted Fertilization Techniques in Systemic Immunoreumatologic Diseases
Systemic rheumatological diseases often occur in young women of childbearing age and can therefore impact fertility. There are diseases, such as arthritis, which present no contraindication to assisted reproductive techniques…
- Conditions
- Rheumatic Diseases, Fertility Disorders, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- NCT05807256
- Testing
- collection and analysis of treatments and procedures already performed by normal clinical practice
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Sarcopenic Obesity
Dissecting the Molecular and Cellular Pathophysiology of Sarcopenic Obesity in the Elderly
Ageing is characterised by a change in body composition with a parallel decrease in muscle mass and an increase and central redistribution of fat.
- Trial name
- NCT06320158
- Testing
- clinical evaluation of sarcopenic obesity
- Where
- Italy
- Volunteers
- 1,108 people
- Sponsor
- IRCCS San Raffaele
Brain Metastases, Adult
Glutamate Excitotoxicity in Brain Metastases From Lung, Breast and Melanoma Treated With Stereotactic Radiosurgery
Brain metastases (BM) represents a devastating clinical reality, carrying an estimated survival time of less than one year. Number of reasons, including complicated tumor biology and difficulties in modeling metastatic cancer in…
- Trial name
- NCT04785521
- Testing
- Stereotactic radiosurgery, Blood samples
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Brain Tumor, Primary
Glutamate Excitotoxicity and Its Role in Glioblastoma Biology
Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis.
- Trial name
- NCT05775458
- Testing
- Blood, CSF and tumor samples
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Cerebral Lymphoma
Improving Safety and Accuracy of Stereotactic Brain Biopsies in Primary Central Nervous System Lymphoma.
Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non- Hodgkin lymphoma exclusively localized into the nervous system.
- Trial name
- NCT06263361
- Testing
- MRI imaging, Cerebral biopsy
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS San Raffaele
Primary CNS Lymphoma
Diagnosis; Objective RespOnse; THErApy
Thi is a prospective and low-intervention clinical trial. We propose to design a panel of "core" genetic alterations by sequencing Cerebral Spinal Fluid (CSF) DNA in patients with confirmed or suspicious Primary Central Neurvous…
- Trial name
- DOROTHEA (NCT05036564)
- Testing
- Lumbar puncture
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS San Raffaele
Coronavirus Infections
Establishment of a Biological Biobank of Subjects Vaccinated Against SARS-CoV-2 Infection (COVID-19)
Establishment of a biological bank of subjects vaccinated against SARS-Cov-2 infection (COVID-BioVac)
- Trial name
- NCT05276388
- Testing
- biological bank
- Where
- Italy
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Urothelial Carcinoma (UC)
A Patient-Directed Mobile Tool to Streamline the QoL Assessment and Monitoring in Urothelial Carcinoma
The goal of this observational study is to select contents and tools for the future development of a web app aiming to support patients' navigation for empowering decision-making through a higher awareness of urothelial carcinoma…
- Trial name
- Urolife (NCT06982794)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele