Clinical trials: sponsored by IRCCS San Raffaele
Radiation Exposure
Enhancing Radiation Safety for Nuclear Medicine Radiographers: the Impact of Introducing the Automat-ed Radiopharmaceutical Preparation and Administration System
This project aims to evaluate the impact of the introduction of an automated system for radiopharmaceutical preparation and administration on the radiation safety of the radiographers working in nuclear medicine.
- Trial name
- NCT06371703
- Testing
- automated system in reducing radiation exposure
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Breast Cancer Female, Chemotherapy Effect
Monitoring Response to NAC and Prediction of pCR in Breast Cancer Patients Using Optical Imaging
Neoadjuvant chemotherapy (NAC) is the first line treatment for locally advanced breast cancer (BC). Besides making breast conserving surgery feasible, its main aim is to achieve a pathological complete response (pCR).
- Trial name
- NCT04767659
- Testing
- MAMMOT2
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Female Urinary Incontinence
Women Urinary Incontinence Prevalence Study (WUIPS)
The goal of this multicenter prospective and prevalence observational study is to punctually investigate and describe prevalence, predictors, quality of life and costs of Urinary Incontinence (UI) among female patients, female…
- Trial name
- NCT06291441
- Testing
- No intervention
- Where
- 4 sites in Italy
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Acromegaly
The RApid Switch From 1st Generation Somatostatin Analogues to PaSireOtiDe In Acromegaly
This is an observational, retrospective, national multicenter study aimed to evaluate the impact and efficacy of Time To Switch (TTS) from first-line to second-line medical therapy in Acromegaly.
- Trial name
- RAPSODIA (NCT06597383)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Acromegaly
Cellular, Molecular and Clinical Determinants of Bone Strength in in Vivo and Human Models of GH Excess.
Prospective observational clinical, molecular, translational study aimed at identifying the main determinants and predictive factors of fragility fracture risck in acromegaly patients
- Trial name
- NCT06344650
- Testing
- Blood sample, Radiological tests, Questionnaires
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral Sclerosis
The investigators hypothesize a relevant impact of cognitive status over gait performance in patients with amyotrophic lateral sclerosis (ALS), contributing to poor mobility and representing a relevant risk for falls.
- Trial name
- NCT06541873
- Testing
- Clinical and gait evaluation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Obesity; Endocrine, Pituitary Dysfunction
NEUROENDOCRINE REGULATION OF BONE-FAT CROSSTALK IN OBESITY
To study the effect of neuroendocrine dysfunctions on bone health in obesity
- Conditions
- Obesity; Endocrine, Pituitary Dysfunction, Bone Health
- Trial name
- NCT06540820
- Testing
- Dexa or Biompedance analysis with clinical and biochemical evaluations
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Schizophrenia, Bipolar Disorder
A Biological Signature for the Early Differential Diagnosis of Psychosis
Schizophrenia (SZ) and mood disorders (BD, MDD) are among the most disabling disorders worldwide, with a relevant social, functional, and economic burden.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT06515522
- Testing
- differential diagnosis
- Volunteers
- 1,850 people
- Sponsor
- IRCCS San Raffaele
Thyroid, Thyroid Cancer
Parathyroid Vascularization During Total Thyroidectomy Using Indocyanine Green Angiography
Prospective, observational, single-center study about the use of indocyanine green angiography during total thyroidectomy. The main objective of the study is to identify a quantitative score of parathyroid vascularization as an…
- Conditions
- Thyroid, Thyroid Cancer, Hypoparathyroidism, Vascularization
- Trial name
- ANGIO_PARA (NCT05328076)
- Testing
- Indocyanine green, SPY Portable Handheld Imaging (SPY-PHI)
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
PET/MRI to Stage Prostate Cancer Patients
The main goal of this phase II clinical trial is to define a novel approach of staging prostate cancer (PCa) patients by using a fully integrated positron emission tomography/ magnetic resonance imaging (PET/MRI) system with…
- Trial name
- NCT06484361
- Testing
- 68Ga-PSMA, 68Ga-RM2
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Breast Cancer, Genetic Predisposition
Oncotype DX in BRCA-mutated Breast Cancer Patients: Our Experience. A Retrospective Observational Monocentric Study
The study aims to evaluate the distribution of the Oncotype DX RS® genomic test in patients with ER-positive and HER2-negative breast cancer treated from January 2012 to December 2021, focusing on patients presenting germline…
- Trial name
- OnBRA (NCT06484725)
- Testing
- Oncotype DX assay
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Patients With Histologically Confirmed CD Undergoing Intestinal Resection According to Standard of Care Due to Complicating Disease, Patients With Histologically Confirmed UC Undergoing Intestinal Resection According to Standard of Care Due to Complicating Disease
Spatially Resolved IBD: Spatial Transcriptomics of Inflammatory Bowel Disease (IBD)
The goal of this retrospective observational study is to obtain the spatial resolution of the entire intestinal fibrotic process through the technology STOmics Stereoseq.
- Trial name
- NCT06484738
- Testing
- transcriptomic analysis
- Where
- 2 sites in Italy
- Volunteers
- 16 people
- Sponsor
- IRCCS San Raffaele
Perinatal Depression, Anxiety
Maternal Well-being in the Perinatal Period
The goal of this observation study is to investigate the mental health status of women experiencing their first pregnancy, with particular attention to anxiety and depression symptoms, feelings of loneliness, and the quality of…
- Conditions
- Perinatal Depression, Anxiety, Loneliness, Mother-Child Relations
- Trial name
- NCT06473935
- Testing
- Questionnaires and focus groups
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- IRCCS San Raffaele
Epilepsy, Focal Epilepsy
Cognitive Impairment in Drug-resistant and Drug-responsive Focal Cryptogenic Epilepsy
This is a national monocentric (San Raffaele Hospital - OSR, Via Olgettina, 60, 20132 Milan, Italy) observational low-risk-intervention study, prospective and multiparametric (clinical, EEG, neuropsychological evaluations) study.
- Trial name
- NCT06210022
- Testing
- Neuropsychological Assessment
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- IRCCS San Raffaele
Acute Stroke, Functional Recovery
Prognostic Recovery Observations and Guidance for Evaluating Stroke Survivors
This research delves into the acute prognostic factors influencing functional recovery in individuals who have experienced a stroke.
- Conditions
- Acute Stroke, Functional Recovery, Prognostic Factors
- Trial name
- PROGRESS (NCT06465758)
- Where
- Italy
- Volunteers
- 360 people
- Sponsor
- IRCCS San Raffaele
Endocrine Disorders, Adiposity
Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models
The goal of this observational study is to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary…
- Conditions
- Endocrine Disorders, Adiposity, Pituitary Adenoma, Cushing Syndrome
- Trial name
- NCT06326853
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Hypoparathyroidism
Endocrine Determinants of Renal Function in Patients With Hypoparathyroidism
Endocrine determinants of renal function in patients with hypoparathyroidism on conventional treatment: a cross-sectional study (ENDORSE)
- Trial name
- ENDORSE (NCT06449729)
- Testing
- Blood sample and urine collection
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- IRCCS San Raffaele
Hereditary Neuropathy
Impact of Sensory, Motor and Vestibular Deficit on the Postural Stability of CMT Patients
Charcot-Marie-Tooth (CMT), a therapeutically orphan neuromuscular disease affecting one in 2,500 people, represents a challenge to the medical and scientific communities.
- Trial name
- EquiCMT (NCT06425952)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Pelvic Organ Prolapse, Gynecologic Disorders
Comparison of Learning Curves for Two Different Techniques in Vaginal Hysterectomy
Randomized prospective monocentric interventional study to compare learning curves for traditional vaginal hysterectomy and vaginal hysterectomy performed by bipolar coagulation comparing short-term outcomes for both procedures.
- Conditions
- Pelvic Organ Prolapse, Gynecologic Disorders, Surgery
- Trial name
- NCT06220253
- Testing
- vaginal hysterectomy by bipolar vessels sealing, vaginal hysterectomy by traditional technique
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pelvic Organ Prolapse, Vaginal Prolapse
The Impact of Long-term Pessary Use on Pelvic Organ Prolapse oìduring Covid-19 Pandemic in Patients Attending Surgery
Patients aged 45 to 80 years with a clinical diagnosis of stage III and IV genital prolapse involving the anterior and/or middle compartments and candidates for surgery will be considered.
- Trial name
- NCT06234449
- Testing
- Vaginal pessary before surgery for pelvic organ prolapse
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele