Clinical trials: sponsored by IRCCS San Raffaele
Mild Cognitive Impairment (MCI), AMCI - Amnestic Mild Cognitive Impairment
Effects of Combined Aerobic and Cognitive Training in a Simultaneous or Sequential Paradigm on Cognition and Brain Functional Activity in Patients with AMCI
Mild Cognitive Impairment (MCI) is a condition in which patients show an objective evidence of impairment in one or more cognitive domains but a spared independence in daily functional abilities.
- Conditions
- Mild Cognitive Impairment (MCI), AMCI - Amnestic Mild Cognitive Impairment, Neurodegenerative Dementia, Neurodegenerative Disease
- Trial name
- NCT06755164
- Testing
- Simultaneous aerobic and cognitive training (SIM), Sequential aerobic and cognitive training (SEQ)
- Where
- Italy
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Bicuspid Aortic Valve (BAV)
Size Up Bicuspid With the LIra MEthod: the SUBLIME Study
Transcatheter aortic valve replacement (TAVR) outcomes in patients with raphe-type bicuspid aortic valve (BAV) are still suboptimal for the non negligible rate of stroke and permanent pacemaker implantation.
- Trial name
- SUBLIME (NCT06657911)
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
The Horseshoe Kidney
Semi-automatic Measurement of Renal Volume at CT Angiography to Plan Repair of Aortic Aneurysms in Patients With Horseshoe Kidney.
The horseshoe kidney (HK) is a congenital anomaly in which the kidneys are fused in front of the anterior aortic wall in its most common form.
- Trial name
- NCT06749782
- Testing
- TC
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- IRCCS San Raffaele
Urinary Incontinence , Stress, Incontinence
Bladder Wall Thickness in Symptomatic Urinary Stress Incontinence and Its Correlation with Urodynamics Results
This clinical study aims to assess the utility of ultrasonographic bladder wall thickness (BWT) measurement in patients suffering from symptomatic stress urinary incontinence (SUI).
- Trial name
- BWT-IUS (NCT06740058)
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
HBV (Hepatitis B Virus), HIV Infection
Occult Hepatitis B Virus Infection and HBV Reactivation After Switching to Long Acting Therapy in Patients With HIV-1
The primary objective of the present project will be to investigate the risk of HBV reactivation (from virological reactivation to overt HBV infection) in HIV-1 carriers with occult HBV infection (OBI, is characterized by the…
- Trial name
- OBILART (NCT06728917)
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Type 1 Diabetes
Intervention on New Onset-T1D Children
A pilot proof of concept clinical trial will be performed to demonstrate the restoration of gut barrier integrity by administration of beneficial anti-inflammatory gut microbial strains (Lactobacilli-enriched Vivomixx® probiotic)…
- Trial name
- NCT05767450
- Testing
- Probiotic Vivomixx®
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Intraductal Papillary Mucinous Neoplasm of Pancreas, Pancreatic Cyst
Endocrine, Metabolic, Inflammatory Biomarkers to Identify Highgrade Dysplasia/invasive Carcinoma in Patients with IPMN of the Pancreas
Under the hypotheses that a more accurate patients selection could limit the problem of overtreatment and that benign intraductal papillary mucinous neoplasms (IPMN) have a distinguishable Endocrine/Metabolic/Inflammatory (EMI)…
- Trial name
- EMI-IPMN (NCT06706700)
- Where
- Italy
- Volunteers
- 586 people
- Sponsor
- IRCCS San Raffaele
COVID 19
Bio-reconfigurable Electronic Platform for Multiplex Detection of Viral Respiratory Pathogens
This project focuses on developing a cutting-edge electronic biosensor platform for highly sensitive and specific detection of target biomolecules, with initial applications targeting SARS-CoV-2 detection.
- Trial name
- BIOPLEX (NCT06702540)
- Testing
- Biosensor chip
- Where
- Italy
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Self-awakening: Ability to Wake Up Without the Aid of Any Timekeeper
Cognitive Control During Sleep: the Strange Case of Self-Awakening
The experimental model of self-awakening highlights several important issues, particularly the lack of a reliable model for estimating the time interval, from minutes to hours, that passes between falling asleep at night and the…
- Trial name
- SAS (NCT06685380)
- Testing
- Not applicable- observational study
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele
Glioblastoma, Cytokine-Induced Killer Cells
Optimizing Cytokine-Induced Killer Cells in Glioblastoma Patients
The goal of this prospective observational cohort study is to assess the optimal in vitro production protocol for generating Cytokine-Induced Killer (CIK) cells, a type of T lymphocyte, and to evaluate the potential adverse…
- Trial name
- KillGlio (NCT06684899)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
OSA - Obstructive Sleep Apnea
Multidisciplinary Network OSA Code (Obstructive Apnea Syndrome): Digital Operative Model in Public Health for an Early Diagnosis and Therapy Monitoring
Obstructive Sleep Apnea Syndrome (OSAS) is a sleep related breathing disorder with high epidemiological impact (9-38% of general population), more frequently reported in male gender and increasing with the age.
- Trial name
- DOMOSA (NCT06677580)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Urinary Bladder Cancer
Predictive Role of Microbiome in Patients With Urothelial Carcinoma
This study aims to establish the microbiota composition as a predictive tool for the response to the intravesical immunotherapy with Bacillus Calmette-Guérin (BCG) and 2 different chemotherapies schemes.
- Trial name
- NCT06675656
- Testing
- DNA extraction from urine, stool and biopsy. Isolation of serum and PBMC from peripheral blood.
- Volunteers
- 420 people
- Sponsor
- IRCCS San Raffaele
Head and Neck Cancer
Predictors of Acute Toxicity and Flap Failure After Adjuvant Treatment for Locally Advanced Head and Neck Cancer
Head and Neck cancer treatment may have significant functional consequences. Decisions about treatment are usually hard to make, as they must strike a balance between efficacy of the treatment and likelihood of survival.
- Trial name
- NCT06661265
- Testing
- adjuvant tomotherapy +- chemotherapy after the reconstructive surgery with flaps
- Volunteers
- 46 people
- Sponsor
- IRCCS San Raffaele
Primary Hyperparathyroidism
Diagnostic Performance of [11C]Choline PET/CT In the Preoperative Assessment of Primary Hyperparathyroidism
Primary hyperparathyroidism (HPT) ranks as the third most common endocrine disorder, characterized by excessive secretion of parathormone (PTH), a hormone crucial for regulating calcium and phosphorus metabolism within the body.
- Trial name
- NCT06647966
- Testing
- PET/CT
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Lung Cancer Screening
Advancing Lung Cancer Screening: Artificial Intelligence, Multimodal Imaging and Cutting-Edge Technologies for Early Detection and Characterization
Currently available screening programmes for lung cancer are limited by many challenges including low diagnostic accuracy, radiation exposure and high costs.
- Trial name
- NCT06531343
- Testing
- LDCT scan and simultaneous [18F]FDG PET/CT on new-generation long axial field of view scanner, LDTC only
- Where
- Italy
- Volunteers
- 334 people
- Sponsor
- IRCCS San Raffaele
Chronic Pain, Osteo Arthritis Knee
Persistent Pain in Pharmacologically or Surgical Treated Osteoarthritis: Role of Mu-Limpho Marker
The goal of this prospective observational study is to analyze the percentage of expression of B and NK cells expressing Mu opioid receptor on their surface, named Mu-Lympho-Marker (MLM), to measure pain progression in…
- Trial name
- MLM (NCT06637709)
- Where
- Italy
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Pancreatic Ductal Adenocarcinoma (PDAC)
Innovative Therapeutic Treatments to Inhibit Perineural Invasion in Pancreatic Adenocarcinoma
The overall goal of this project is to develop new therapeutic approaches to limit Perineural invasion (PNI) in pancreatic ductal adenocarcinoma (PDAC).
- Trial name
- PNIPDAC (NCT06616688)
- Testing
- Organoid-guided treatment
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Cancer of Thyroid, Vertebral Fracture
Study of the Prevalence of Osteo-metabolic Complications in Patients With Thyroid Cancer
This is a multicenter retrospective observational study aimed to evaluate the prevalence of osteo-metabolic complications in patients with thyroid cancer.
- Conditions
- Cancer of Thyroid, Vertebral Fracture, Osteoporosis
- Trial name
- NCT06627998
- Testing
- Diagnostic (chest x-ray /DXA)and clinical data collected for clinical practice
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- IRCCS San Raffaele
Radiation Exposure
Enhancing Radiation Safety for Nuclear Medicine Radiographers: the Impact of Introducing the Automat-ed Radiopharmaceutical Preparation and Administration System
This project aims to evaluate the impact of the introduction of an automated system for radiopharmaceutical preparation and administration on the radiation safety of the radiographers working in nuclear medicine.
- Trial name
- NCT06371703
- Testing
- automated system in reducing radiation exposure
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Acromegaly
The RApid Switch From 1st Generation Somatostatin Analogues to PaSireOtiDe In Acromegaly
This is an observational, retrospective, national multicenter study aimed to evaluate the impact and efficacy of Time To Switch (TTS) from first-line to second-line medical therapy in Acromegaly.
- Trial name
- RAPSODIA (NCT06597383)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele