Clinical trials: sponsored by IRCCS San Raffaele
Infertility
Reduction of Progesterone Elevation at Trigger in POR After Long Acting COS Compared With Daily COS: a Prospective Randomized Trial
The overarching objective of this research is to generate clinical evidence to argue the benefits of long acting stimulation protocol compared to the daily stimulation protocol in poor ovarian responder bologna' criteria patients…
- Trial name
- PE-PMA (NCT04695483)
- Testing
- Corifollitropin alfa, Follitropin Beta
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis, Crohn's Disease
Non-invasive Assessment of RECTUM (POUCH) by US (RECT-US) in a Cohort of IBD Patients
At enrollment, after informed consent form will be discussed and signed, subjects will undergo complete disease assessment. In this study, 150 adult subjects with IBD will be enrolled at the Gastroenterology Department of the San…
- Trial name
- RECT-US (NCT06407674)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Observational Study of Patients Who Underwent Diagnostic Investigation (Prostate Biopsy) and/or Radical Prostatectomy Surgery.
This is a single-center, observational, prospective and retrospective study on quality of life and disease status of patients who underwent prostate biopsy and/or radical prostatectomy.
- Trial name
- NCT06397755
- Testing
- Prostate Biopsy and/or Radical Prostatectomy
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- IRCCS San Raffaele
Testicular Cancer
Study on the Quality of Life and Functional/Oncological Outcome of Testicular Cancer Patients
The research aims to collect data in order to report the main problems related to the testicular cancer; To reach this aim, this study proposes to create a database of the testicular cancer condition.
- Trial name
- NCT06389409
- Testing
- Observation of testicular cancer patients
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- IRCCS San Raffaele
Brugada Syndrome
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome
Brugada Syndrome (BS) is an inherited heart condition that can cause sudden cardiac arrest in young individuals. It's diagnosed through specific changes seen on an electrocardiogram (ECG).
- Trial name
- AI4Cardio (NCT06376552)
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer, Endoscopic Ultrasound
Ex-vivo Ultrasound Guided Radiofrequency Ablation on Pancreatic Solid Lesions
The study investigates the feasibility and the efficacy to treat pancreatic solid lesions as pancreatic adenocarcinomas (PDAC) and neuroendocrine tumors (NET) with ex-vivo radiofrequency ablation (RFA) under ultrasound (US)…
- Conditions
- Pancreatic Cancer, Endoscopic Ultrasound, Radiofrequency Ablation
- Trial name
- NCT06371716
- Testing
- ex-vivo RFA under US control at 10 Watts (W) of power in 3 differents arms of lesions, ex-vivo RFA under US control at 30 Watts (W) of power in 3 differents arms of lesions, ex-vivo RFA under US control at 50 Watts (W) of power in 3 differents arms of lesions
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele
Hepatocellular Carcinoma, Cholangiocarcinoma
Liver Embolization Approaches for Tumor Management
The goal of this evaluate short, medium and long term outcome of the different embolization techniques in patients with primary and secondary hepatic tumors.
- Conditions
- Hepatocellular Carcinoma, Cholangiocarcinoma, Metastatic Colon Cancer, Metastatic Cancer
- Trial name
- LEATUM (NCT05714124)
- Testing
- Embolization
- Where
- Italy
- Volunteers
- 580 people
- Sponsor
- IRCCS San Raffaele
Severe Stroke, Acute Stroke
Efficacy of End-Effector Robot-Assisted Gait Training in Subacute Stroke Patients
To date, no studies seems to compare conventional gait rehabilitation program with end-effector RAGT in subacute stroke patients by analysing the variations of gait kinematics beyond clinical multi prospective outcomes.
- Conditions
- Severe Stroke, Acute Stroke, Mild Stroke, Central Nervous System Diseases
- Trial name
- NCT03805009
- Testing
- Robot-Assisted Gait Training (RAGT)
- Where
- 2 sites in Italy
- Volunteers
- 26 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease
Pilot Study on the Effects of IMOOVE in Parkinson's Disease Patients
Parkinson's Disease (PD) is one of the most frequent causes of motor dysfunction in aging. It is therefore important to use rehabilitative therapeutic approaches that may prevent the development of motor complications when…
- Trial name
- IMOOVE-PD (NCT04568447)
- Testing
- IMOOVE
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- IRCCS San Raffaele Roma
COPD, COPD Exacerbation
Evaluation of Eosinophil Phenotype in COPD Patients
This is a pilot non pharmacological observational study. Aim of the study is to analyze the immunophenotype of circulating eosinophils in chronic obstructive pulmonary disease (COPD) patients, and to correlate results with…
- Trial name
- V-FEO (NCT04494308)
- Testing
- biomarker identification
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele Roma
Severe Stroke, Acute Stroke
Stroke Rehabilitation With Exoskeleton-assisted Gait.
Gait recovery is one of the main goals of post-stroke rehabilitation where robotic-assisted practice has shown positive outcomes. However, literature lacks of clinical studies on exoskeleton-supported gait rehabilitation.
- Conditions
- Severe Stroke, Acute Stroke, Chronic Stroke, Cerebrovascular Disorders
- Trial name
- EKSOGAIT (NCT03395717)
- Testing
- Exoskeleton-Assisted Gait Training
- Where
- 4 sites in Italy
- Volunteers
- 162 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease
Pilot Study on the Effects of Neuromuscular Taping in Parkinson's Disease Patients
Parkinson's disease (PD) is a degenerative disorder characterized by a symptom triad consisting on: tremor, rigidity and bradykinesia .
- Trial name
- NMT-PD (NCT03104049)
- Testing
- Neuromuscular taping
- Volunteers
- 46 people
- Sponsor
- IRCCS San Raffaele Roma
COVID19, Vaccination
Spike-specific Cellular Immune Response After COVID-19 Vaccination
Aim of this study is to evaluate whether COVID-19 vaccination induces a persistent cellular immune response. To this aim, blood samples are taken from vaccinated individuals and not immunized subjects as a control group.
- Conditions
- COVID19, Vaccination, Immune Response
- Trial name
- RIS-COV (NCT05102669)
- Testing
- analysis of immunological response, analysis of serum antibodies
- Where
- Italy
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Stroke, Gait Disorders, Neurologic
Robot Walking Rehabilitation in Stroke Patients
Stroke are the main causes of motor disability among adults and are expected to impose an increasing social and economic burden for our Country.
- Trial name
- RoboSTROKE (NCT01678547)
- Testing
- Robot-assisted walking, Treadmill Training, Ground treatment
- Where
- 2 sites in Italy
- Volunteers
- 28 people
- Sponsor
- IRCCS San Raffaele Roma
Idiopathic Parkinson's Disease, Progressive Supranuclear Palsy
Robot Walking Rehabilitation in Parkinson's Disease
The effectiveness of non-pharmacological treatment on gait impairment on Parkinson Disease (PD) such as exercises has been demonstrated; in particular an example for patient tailored exercises is physiotherapy.
- Trial name
- ROBOPARK (NCT01668407)
- Testing
- Robot-Assisted Gait Training (RAGT), Treadmill Gait Training (TT)
- Where
- 3 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele Roma
Idiopathic Parkinson's Disease, Progressive Supranuclear Palsy
Foot Mechanical Stimulation for Treatment of Gait and Gait Related Disorders in Parkinson's Disease and Progressive Supranuclear Palsy.
The purpose of this research study is to evaluate safety and effectiveness of Foot Mechanical stimulation to improving Gait and Gait Related Disorders in Parkinson Disease and Progressive Supranuclear Palsy both stable and with…
- Trial name
- GONDOLAPILOTA (NCT01815281)
- Testing
- Foot Mechanical Stimulation (GONDOLA)
- Where
- 3 sites in Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Hypertension, Cardiac Disease
Effects of Exercise Training on Blood Pressure Variability
A Randomized clinical evaluation of the effects of 2 exercise training modalities on blood pressure variability. Recruited subjects will be randomized in two interventional arms: 1) aerobic exercise; 2) combined exercise…
- Trial name
- VARIABILITA' (NCT04282499)
- Testing
- combined exercise, aerobic exercise
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS San Raffaele Roma
Distress, Emotional, Coping Behavior
COVID-19 and Psycological Well-being in Healthcare Workers
Well-being of healthcare workers is assessed by specific questionaries validated for resilience, depression, anxiety, coping strategies and fear for COVID-19.
- Trial name
- BE-STRONG (NCT04890600)
- Testing
- well-being assessment
- Where
- Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease (PD), Paralysis; Supranuclear
Progression of Striatal and Extrastriatal Degeneration in PD and PSP Patients
This longitudinal study aims to research cognitive and gait phenotypes of Parkinson's disease and Supranuclear Palsy as well as to provide markers to track diseases progression using a multi-modality approach based on 3D-gait…
- Trial name
- PARKONTHEWAY (NCT03840252)
- Testing
- 3D gait analysis, rsfMRI, Montreal Cognitive assesment (MoCA)
- Where
- Italy
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Migraine, Prophylaxis
Atogepant in Real Life in Italy (GIANT)
Atogepant is an oral, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist that has been approved for the preventive treatment of episodic and chronic migraine (>= 4 monthly migraine days) with or without…
- Trial name
- GIANT (NCT06136442)
- Testing
- Atogepant
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele Roma