Clinical trials: sponsored by IRCCS San Raffaele
Diffuse Large B-cell Lymphoma
Trial on Lenalidomide Given as Maintenance Therapy for Relapsed Diffuse Large B Cell Lymphoma
This phase II multi-institutional trial will explore the safety and efficacy of lenalidomide monotherapy given as maintenance therapy following salvage chemo-immunotherapy in patients with relapsed or refractory chemosensitive…
- Trial name
- RV-NHL-PI351 (NCT00799513)
- Testing
- Lenalidomide
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- IRCCS San Raffaele
Parkinson Disease
Levodopa Benserazide Generic Formulation Versus the Originator
The trial was an experimental two-centers, randomized, double-blind, two-sequence, non-inferiority cross-over study. Screened subjects already treated with Levodopa/Benserazide (LDB) (Madopar®) who agreed to participate in the…
- Trial name
- FARM9X59Y4 (NCT02741947)
- Testing
- Levodopa Benserazide Madopar, Levodopa Benserazide Teva Italia
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease
Overnight Switch From Rasagiline To Safinamide
Rasagiline label report the indication to wait at least 14 days between discontinuation of rasagiline and initiation of another MAO inhibitor.
- Trial name
- SWH-MAOB (NCT03843944)
- Testing
- Safinamide
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease
Treatment of Chronic Constipation in Parkinson's Disease
Chronic constipation is the most common gastrointestinal symptom reported by PD patients; it could be one of the manifestations of disease onset.
- Trial name
- PHGG-PD (NCT04569656)
- Testing
- hydrolyzed guar gum
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- IRCCS San Raffaele Roma
Knee Arthropathy, Total Knee Replacement
Virtual Reality Rehabilitation in Patients With Total Knee Replacement
Impaired proprioceptive accuracy could be a risk factor for progression of gait limitations in knee osteoarthritis patients, even after the Total Knee Replacement (TKR).
- Trial name
- VRRS_KNEE (NCT03454256)
- Testing
- Virtual Reality
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- IRCCS San Raffaele Roma
Healthy, Chronic Disease
Serum Prevalence of SARS-Cov-2 Antibodies in Pre-pandemic Blood Samples (SPARE)
The first reports of infections caused by SARS-CoV-2 were released from Wuhan, China in December 2019. From there, the infection quickly spread into a pandemic form.
- Trial name
- SPARE (NCT04712448)
- Testing
- Anti-COVID test
- Where
- Italy
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease
Study on the Device "Gondola" for Motor Rehabilitation in Parkinson's Disease
The purpose of this research study is to evaluate safety and effectiveness of the Automated Mechanical Peripheral Stimulation (AMPS) therapy given via the Gondola™ device to improving Gait and Gait Related Disorders in patients…
- Trial name
- GondoPark V2 (NCT03843268)
- Testing
- AMPS Gondola
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease
Intermittent Oral Administration vs. Semi-continuous Intra-oral Administration of Levodopa/Carbidopa in Fluctuating Parkinsonian Patients
This is a phase IIa study to assess the safety, tolerability, plasma pharmacokinetics and efficacy of intermittent oral administration of standard levodopa/carbidopa (LD/CD) vs.semi-continuous intra-oral administration of…
- Trial name
- LDCD-001 (NCT02763137)
- Testing
- Standard LD/CD, Semi continuous intra-oral administration of LD/CD
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease
Mister Parkinson: Educational Therapy in Parkinson's Disease (PD)
Parkinson's disease is multidimensional disorders characterized by motor and non-motor symptoms such as behavioral and psychological symptoms, autonomic disturbances and other non-motor symptoms.
- Trial name
- NCT04378127
- Testing
- Educational program
- Volunteers
- 120 people
- Sponsor
- IRCCS San Raffaele Roma
Cardiac Ischemia
Ischemia in Patients With Non-obstructive Disease (INOCA) in Italy INOCA IT Multicenter Registry"
Prospective, interventional, multicentre, non-randomized, single-arm open-label study that aims to enroll 200 consecutive patients with suspected chronic ischemic heart disease in the absence of obstructive coronary artery…
- Trial name
- INOCAIT (NCT05164640)
- Testing
- not required
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Bladder Cancer
Investigator Grant (IG) 2022 27746
Background: Muscle-invasive bladder cancer (MIBC) is a systemic disease as >40% of patients (pts) ultimately develop recurrence after radical cystectomy (RC).
- Trial name
- NCT06341478
- Testing
- various neoadjuvant therapies
- Where
- Italy
- Volunteers
- 153 people
- Sponsor
- IRCCS San Raffaele
Muscular Dystrophy, Duchenne
Characterization of DupEx2 Duchenne Muscular Dystrophy
To characterize the clinical phenotype and possible predictive/prognostic factors of patients with Duchenne muscular dystrophy (DMD) due to duplication of exon 2 (Dup2).
- Trial name
- DMDDup2 (NCT06337669)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis
The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis.
- Trial name
- NCT06025903
- Where
- 2 sites in Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS San Raffaele
Mood Disorders, Major Depressive Disorder
Inflammatory Control of Antidepressant Efficacy: a Pharmaco-epigenetic Approach
Major depressive disorder (MDD) is a chronic, recurring and potentially life-threatening illness that affects up to 10% of the population across the globe.It posits that the increase in serotonin levels induced by Selective…
- Trial name
- NCT06306209
- Testing
- Treatment as usual (TAU), i.e., pharmacotherapy plus clinical management
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis
Controlling the Mental Health for a Better Response to Treatment in Patients With Ulcerative Colitis
The project aims to implement the Internet Of Thing (IoT) platform of the San Raffaele Hospital (OSR) with data from stress conditions perceived by the patient through the synergistic collaboration between patients…
- Trial name
- TIMAEUS (NCT06306261)
- Testing
- questionnaire
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Mood Disorders, Major Depressive Disorder
Immune Activation, Neural Plasticity and Depression
Major depressive disorder (MDD) is a chronic, recurring and potentially life-threatening illness that affects up to 10% of the population across the globe.Increasing evidence indicates a clear link between immune dysfunction and…
- Conditions
- Mood Disorders, Major Depressive Disorder, Sleep Deprivation
- Trial name
- NCT06306248
- Testing
- Total sleep deprivation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Kidney Stone, Ureteral Stone
Thulium Fiber Laser vs. Holmium:YAG Laser for the Ureteroscopic Treatment of Patients With Urinary Stone Disease
This is a randomized controlled trial which aims to compare the efficacy and safety of Thulium fiber laser (TFL) and holmium:yttrium-aluminum-garnet (Ho:YAG) laser ablation during the treatment of upper urinary tract stone…
- Trial name
- NCT06306222
- Testing
- Laser lithotripsy
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS San Raffaele
Neuroendocrine Tumors
Evaluation of the Diagnostic and Prognostic Role of PET (PET/CT and PET/MRI) in Neuroendocrin Tumors.
Neuroendocrine tumors (NETs) constitute approximately 0.5% of malignancies. To date, diagnosis at an increasingly early stage of the disease is possible thanks to recent technological advances in biomedical imaging.
- Trial name
- NCT06159920
- Testing
- diagnostic accuracy
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
11C-choline PET/CT Based Helical Tomotherapy as Innovative Treratment Approach for Bone Metastases in Prostate Cancer Patients.
The number of metastases may reflect the biological aggressiveness of the tumor and may determine the possibility of performing potential curative interventions such as surgery or high-dose targeted radiotherapy (RT).
- Trial name
- NCT06179706
- Testing
- 11C-choline PET/CT
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Gynecological Tumors
Evaluation of the Diagnostic and Prognostic Role of PET (PET/CT and PET/MRI) in Gynecological Tumors.
Gynecological cancers involve several tumors of the female reproductive system. The five most common gynecological tumors are those of the uterine cervix, endometrium, ovary, vagina and vulva.
- Trial name
- NCT06159907
- Testing
- the diagnostic and prognostic value of PET/MRI and PET/CT with 18F-FDG in patients presenting with gynecological tumors
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- IRCCS San Raffaele