Clinical trials: sponsored by IRCCS San Raffaele
Magnetic Resonance
Functional Magnetic Resonance Imaging Study on the Role of Awareness in Visual Perception in Healthy Adult Subjects.
The objective of the study concerns the investigation of the role of awareness in visual perception, highlighting the brain systems involved during non-processing Aware of stimuli belonging to different semantic categories.
- Trial name
- NCT06183775
- Where
- Italy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Infertility, Male Infertility
"System Medicine" Approach for Prevention Strategies for Comorbidities in Infertile Men
By applying a "system medicine" approach, the project aims to identify new biomarkers and/or prognostic tools aimed at developing personalized strategies to prevent the onset of comorbidities in infertile men.
- Trial name
- NCT06183255
- Testing
- Observation and evaluation of clinical parameters in the two cohorts
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Benign Prostatic Hyperplasia
Protocollo N 2014 - Benign Prostatic Hyperplasia
Prospective observational study on the quality of life of patients with BPH under medical therapy and/or undergoing surgery.
- Trial name
- NCT06182189
- Testing
- Observation of patients with a benign prostatic hyperplasia condition
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- IRCCS San Raffaele
Azoospermia, Nonobstructive
2015-Metabolomics&Microbiome-infertility
The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding…
- Trial name
- NCT06181851
- Testing
- Analysis of microbiome and metabolomics
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele
Toraco Abdominal Aneurysm
Clinical Study on the Prevention of Surgical Wound Complications for Aneurysmal Thoracic-abdominal Aortic Pathology Using the "PREVENA" System
The patients will be randomized into two groups of 100 subjects each one. One arm will be randomized to treatment with a negative topical pressure system (Sistema Prevena ™); while the other arm ("control group") will be…
- Trial name
- TVAC (NCT03512470)
- Testing
- Sistema Prevena ™(TVAC), Standard medication
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Alzheimer Disease
PET Study With 11 C-PIB to Evaluate Amyloid Protein Deposits in Mild Cognitive Disorder, Alzheimer's Disease and Early Frontotemporal Degeneration.
Preclinical and clinical data have demonstrated the ability of the 11C-PIB tracer to selectively bind accumulations of amyloid protein, a neuropathological marker characteristic of the neurodegenerative pathologies covered by…
- Trial name
- NCT06179979
- Testing
- PET/CT with 11C-PiB
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Meningioma
Evaluation of Brain Functional Changes With 18F-FDG PET and Cognitive Processes After Brain Radiotherapy for Cavernous Sinus Meningiomas and Non-secreting ACTH Adenomas
The use of radiotherapy for irradiation of all or part of the brain, in the treatment of extracerebral intracranial neoplasms, is growing rapidly, both due to the increase in diagnoses of primary tumors thanks to new imaging…
- Trial name
- NCT06180226
- Testing
- PET CT with 18 FDG .
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Alzheimer Disease
PET Study of Acetylcholine Esterase Activity in Alzheimer's Disease
The aim of this study is to understand regional variations in acetylcholine esterase activity in Alzheimer's disease. In this study the aim is to identify by PET the physiological values of the regional activity of acetylcholine…
- Trial name
- NCT06180252
- Testing
- PET with 11C MP4
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Neurodegenerative Diseases
Study of Cerebral Glucose Metabolism in Neurodegenerative Diseases and Head Trauma
The reason why each specific degenerative disease is characterized by a different FDG PET pattern is still unclear today. There are four main hypotheses proposed to explain this selective vulnerability: 1) Nodal stress, theory…
- Trial name
- NCT06180213
- Testing
- FDG PET
- Volunteers
- 1,570 people
- Sponsor
- IRCCS San Raffaele
Lymphoma
AIMN Multicenter Study: Staging of Lymphomas Using PET/CT
In recent years, the introduction of PET/CT tomographs (which have now almost completely replaced tomographs equipped with PET alone), has allowed a significant increase in diagnostic accuracy in the majority of tumors.
- Trial name
- NCT06179693
- Testing
- Diagnostic accuracy
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- IRCCS San Raffaele
COVID-19, Testosterone Deficiency
SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY
The hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with SARS-CoV-2.
- Conditions
- COVID-19, Testosterone Deficiency, Infertility, Male
- Trial name
- PROTEGGIMI (NCT06177002)
- Testing
- Collection of biological data
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Gastroenteropancreatic Neuroendocrine Tumor
68Ga-DOTATOC PET for the Evaluation of Gastroenteropancreatic Neuroendocrine Tumours
Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are a heterogeneous group of neoplasms that arise from the endocrine cells of the gastroenteropancreatic tract.
- Trial name
- NCT06155318
- Testing
- 68Ga-DOTATOC PET as a part of their clinical diagnostic work-up will be included
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Non Small Cell Lung Cancer
Image Mining and ctDNA to Improve Risk Stratification and Outcome Prediction in NSCLC Applying Artificial Intelligence.
Lung cancer is the leading cause of cancer-related death in Europe. Pathological staging is the gold standard, but it can be influenced by neo-adjuvant treatment and number of sampled lymph nodes; it is not feasible in advanced…
- Trial name
- NCT06163846
- Testing
- Assess the role of baseline image mining, ctDNA data and their combination in patient staging and risk stratification
- Where
- Italy
- Volunteers
- 415 people
- Sponsor
- IRCCS San Raffaele
Multiple Myeloma
Role of18F-FDG PET-CT for Assessing and Predicting Response to Daratumumab and for Prognosis With Multiple Myeloma
Positron Emission Tomography - Computed Tomography (PET-CT) using fluorine-18 fluorodeoxyglucose is a functional imaging diagnostic tool which is widely used In several neoplastic conditions, at initial staging, for restaging in…
- Trial name
- NCT06170151
- Testing
- Diagnostic accuracy
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- IRCCS San Raffaele
Parkinson Disease
Prognostic Values of PET Examination With 11 C-Fe_CIT With Voxel-based Analysis Method in Patients With Sporadic Parkonson's Disease and Parkinsonisms (Prot.PD-diagn).
The role of PET for the in vivo study of the presynaptic dopaminergic system with 11C-Fe-CIT is universally recognized, and its use has also become routine in numerous nuclear medicine centers in Europe.
- Trial name
- NCT06171451
- Testing
- PET with 11C-Fe-CIT
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Muscle-Invasive Bladder Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma
Study on the Quality of Life and Pathological State in Patients Who Underwent Radical Cystectomy
Observational study on the quality of life and pathological state of patients underwent radical cystectomy.
- Conditions
- Muscle-Invasive Bladder Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma, Bladder Cancer TNM Staging, Bladder Cancer Stage IIa
- Trial name
- NCT06170177
- Testing
- Radical Cystectomy
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Radiation Treatment of Lymph Node Recurrence From Prostate Cancer : is 11C-choline PET/CT Predictive of Survival Outcomes?
The role of PET/CT with Choline in the restaging of prostatic disease is now universally recognized, and its use has become routine in numerous centers in Italy and abroad.
- Trial name
- NCT06170164
- Testing
- Diagnostic accuracy
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- IRCCS San Raffaele
Head and Neck Cancer
Prognostic Value of Pre-therapy 18F-FDG PET/CT for the Outcome of 18 FDG PET-guided SIB-IMRT in Patients With Head and Neck Cancer
Head and neck cancer is the fifth most common cancer and represents 5% in the world. Selecting patients for the most appropriate treatment remains difficult.
- Trial name
- NCT06171464
- Volunteers
- 19 people
- Sponsor
- IRCCS San Raffaele
Tricuspid Regurgitation, Heart Failure
The Long-term Course of Moderate Tricuspid Regurgitation
To evaluate the long-term clinical outcome of a cohort of patients suffering from moderate tricuspid regurgitation (TR), regardless of its etiology.
- Conditions
- Tricuspid Regurgitation, Heart Failure, Echocardiography
- Trial name
- LOCOMOTRI (NCT06169345)
- Testing
- Echocardiographic evaluation
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Assessment of Predictive Role of [11C] Choline PET/CT on Survival in Prostate Cancer Patients With Biochemical Failure Without Androgen Deprivation Therapy
Among all the patients who underwent PET/CT with choline at our Institute between 2004 and 2007 to restage the prostatic disease following biochemical recovery of the disease, in this retrospective study the patients previously…
- Trial name
- NCT06167824
- Where
- Italy
- Volunteers
- 302 people
- Sponsor
- IRCCS San Raffaele