Clinical trials: sponsored by IRCCS San Raffaele
Infective Graft Complications
Silver Acetate and Triclosan Antimicrobial Graft Evaluation for Surgical Repair of Aortic Disease
The number of surgical and endovascular aortic repairs is continuously increasing, and infective graft complications are observed more frequently.
- Trial name
- NCT04557254
- Testing
- graft
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Covid19, Pulmonary Embolism
Pulmonary Optical Coherence Tomography in COVID-19 Patients
To evaluate by intravascular OCT study the presence of microvascular pulmonary thrombosis in patients with COVID-19, high D-dimer levels and contrast CT scan negative for pulmonary thrombosis.
- Trial name
- NCT04410549
- Testing
- Optical Coherence Tomography (OCT)
- Where
- 2 sites in Brazil, Italy
- Volunteers
- 13 people
- Sponsor
- IRCCS San Raffaele
Gastro Esophageal Reflux
Observational Registry of Transoral Incisionless Fundoplication (TIF) for Gastroesophageal Reflux Disease (GERD)
This observational registry aims to: 1) record the TIF interventions in patients with esophageal or extra-esophageal symptoms; 2) to monitor the therapy response through the clinical experience in terms of effect on the use and…
- Trial name
- TIF/2021 (NCT05066594)
- Testing
- Transoral incisionless fundoplication
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Progressive Multiple Sclerosis
Neural Stem Cell Transplantation in Multiple Sclerosis Patients
This is a phase I study evaluating the feasibility, safety and tolerability of intrathecally administered human Neural Stem Cells (hNSCs), at an escalating dose ranging from 0.7x10^6±10% cells to 5.7x10^6±10% cells/kg of body…
- Trial name
- STEMS (NCT03269071)
- Testing
- human fetal-derived Neural Stem Cells (hNSCs)
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Ductal Adenocarcinoma
PAXG Out in the Country
The objective of this study is to assess the reproducibility of PAXG regimen as first-line/primary chemotherapy in daily clinical practice in Pancreatic Ductal Adenocarcinoma (PDAC) borderline resectable, locally advanced or…
- Trial name
- OINC (NCT04480268)
- Testing
- PAXG regimen (cisplatin, nab-paclitaxel, capecitabine, gemcitabine) chemotherapy
- Where
- 30 sites in Italy
- Volunteers
- 175 people
- Sponsor
- IRCCS San Raffaele
Stage I Pulmonary Adenocarcinoma
Prognostic Role of Positron Emission Tomography and Computed Tomography Parameters in Stage I Lung Adenocarcinoma
The clinical and derived data from the preoperative computed axial tomography (CT) and Positron Emission Tomography (PET) of patients with pathological stage I pulmonary adenocarcinoma will be analyzed retrospectively, classified…
- Trial name
- NCT04202614
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- IRCCS San Raffaele
Covid19
Predictivity of Hemogasanalysis and Lung UltraSound in Determining COVID-19 Severity
This retrospective-prospective longitudinal observational study was designed to evaluate the role of bedside lung ultrasound per se and in association with hemogasanalysis parameters in predicting the severity of COVID-19…
- Trial name
- COVID-PEGALUS (NCT04689672)
- Testing
- Lung ultrasound
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS San Raffaele
Renal Cell Carcinoma (RCC)
FAZA PET IMAGING IN DETECTING LYMPH NODE METASTASES IN RENAL CELL CARCINOMA PATIENTS
In renal cell carcinoma (RCC) patients, lymph node metastases detection and treatment are the most critical issues in daily clinical decision-making.
- Trial name
- FAZA (NCT03955393)
- Testing
- 18F-FAZA PET IMAGING TECHNIQUE IN DETECTING LYMPH NODE METASTASES IN RENAL CELL CARCINOMA PATIENTS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Thoracoabdominal Aortic Aneurysm
"Percutaneous Axillary Access in the Endovascular Treatment of Thoracoabdominal Aortic Pathology" (PAXA)
Since the development of custom-made fenestrated and branched endografts a novel therapeutic option for the management of thoracoabdominal and para-renal aortic aneurysms was made accessible.
- Trial name
- PAXA (NCT03223311)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Aortic Aneurysm, Thoracoabdominal, Para-renal Aortic Aneurysms
Anatomical Feasibility of the Off-the-shelf E-nside Multibranch Stent Graft System for Thoracoabdominal and Para-renal Aortic Aneurysms.(E-nside Study)
The study was created to evaluate the theoretical anatomical feasibility of the new E-nside Multibranch Stent Graft System (JOTEC GmbH, Hechingen) in patients with thoracoabdominal and para-renal aortic aneurysms based on…
- Trial name
- E-nside (NCT03959670)
- Where
- Italy
- Volunteers
- 562 people
- Sponsor
- IRCCS San Raffaele
Aging, Frailty
Renal Ageing-sarcopenia Network
Frailty is a syndrome in which the accumulation of small, individually insignificant deficits leads to heightened vulnerability to adverse events and predisposes to potential catastrophic decompensation.
- Conditions
- Aging, Frailty, Hypertension, CKD
- Trial name
- NCT04630132
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Gastro-esophageal Reflux, Endoscopic Fundoplication
Endoscopic Fundoplication With MUSE System
This is a spontaneous, prospective, monocentric, observational, cohort study, with the aim of evaluating the effect of ultrasound-guided endoscopic fundoplication using the Medigus Ultrasonic Surgical Endostapler (MUSESystem…
- Trial name
- NCT03669874
- Testing
- Endoscopic fundoplication
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele
HCM - Hypertrophic Non-Obstructive Cardiomyopathy
Effects of Ranolazine on Coronary Microvascular Dysfunction in Patients With Hypertrophic Cardiomyopathy
To demonstrate the efficacy of ranolazine in improving coronary microvascular and diastolic dysfunction in patients affected by HCM evaluating changes in maximum (i.e.
- Trial name
- NCT03953989
- Testing
- Ranolazine PR (prolonged-release) 500 mg 1 tablet bis in die and 750 mg 1 tablet bis in die
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- IRCCS San Raffaele
Irradiated Bone Marrow, Transplant-Related Hematologic Malignancy
Treosulfan-TMI Conditioning and Rapamycin GvHD Prophylaxis Before Allo-HSCT
TrRaMM-TMI is a phase I trial to evaluate the feasibility and efficacy of an original sequential TMI/TrRaMM (Total Marrow Irradiation/Treosulfan-Rapamycin-Mycophenolate Mofetil) schedule in patients with hematological…
- Conditions
- Irradiated Bone Marrow, Transplant-Related Hematologic Malignancy, Leukemia, Acute, Multiple Myeloma
- Trial name
- TrRaMM-TMI (NCT03963024)
- Testing
- Conditioning treatment "Treosulfan-TMI", SCT, GvHD prophylaxis
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- IRCCS San Raffaele
Thymoma, Computed Tomography
Prognostic Factors in Patients Submitted to Surgical Treatment for Thymoma
Thymoma is the most common primary tumor of the anterior mediastinum. Complete surgical resection is the mainstay of treatment of these tumors.
- Conditions
- Thymoma, Computed Tomography, Staging, Histology
- Trial name
- NCT04577495
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Early DVC Ligation and Urinary Continence Recovery After RARP
The aim of the study is to evaluate the impact of early deep venous complex ligation (eDVCL) in patients affected by clinically localized prostate cancer (PCa) undergoing robot-assisted radical prostatectomy with or without…
- Trial name
- NCT03368378
- Testing
- Early DVC ligation
- Where
- Italy
- Volunteers
- 312 people
- Sponsor
- IRCCS San Raffaele
Pregnancy Gingivitis, Ozone
Ozone Therapy for the Home Oral Hygiene of the Pregnant Woman.
The aim of the present study is analyzing the effect of an domestic ozonated water delivering device on the oral health status of pregnant women.
- Trial name
- NCT04140643
- Testing
- Ozonated water delivering device effects on the oral health of pregnant women, Oral hygiene instructions
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pancreas Adenocarcinoma
Evaluation of Clinical, Radiomics and Molecular Features of Lung Metastasis in PDAC Patients (LUMACA Trial)
The aim of this study is the characterization from epidemiological, radiomics and molecular point of view of lung metastasis of patients at beginning affected by pancreatic adenocarcinoma (PDAC), which after the resection of…
- Trial name
- LUMACA (NCT04435067)
- Testing
- Analysis of genetic mutations and the gene expression profile of lung metastasis and primary neoplasia, Radiomics analysis on TAC imaging at diagnosis of lung metastasis and, if possible, of the primary tumor
- Where
- 4 sites in Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS San Raffaele
Kidney Transplant, Pancreas Tranplant
Observational Study Concerning COVID-19 Infection in Transplanted Kidney, Pancreas or Pancreatic Islet Patients
Collect informations on the health status of transplanted patients (kidney, kidney / pancreas, pancreas or pancreatic islet) during the COVID-19 pandemic. All informations will be collected by short questionnaire via phone.
- Conditions
- Kidney Transplant, Pancreas Tranplant, Pancreatic Islet Transplantation
- Trial name
- NCT04377776
- Testing
- Practice details
- Where
- Italy
- Volunteers
- 644 people
- Sponsor
- IRCCS San Raffaele
Mitral Regurgitation Functional
Percutaneous Mitral Valve Repair in Cardiogenic Shock: Mitra-Shock Study
Cardiogenic shock (CS) is a medical emergency and a frequent cause of death. CS can be complicated and/or precipitated by mitral regurgitation (MR).
- Trial name
- MSS (NCT04399499)
- Testing
- MitraClip implantation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele