Clinical trials: sponsored by IRCCS San Raffaele
Hemostatic
Clinical Study of Patients Treated With PuraBond Haemostatic Agent During Abdominal Aorta Open Repair
Purabond Study is a physician-initiated, observational, monocentric prospective Trial. The aim of the study is to investigate the hemostatic efficacy of PuraBond for aortic anastomoses and suture lines in patients with abdominal…
- Trial name
- NCT05733585
- Testing
- Purabond
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Urothelial Carcinoma
Sacituzumab Govitecan, Preceding Radical Cystectomy, in Treating Patients With Muscle-invasive Bladder Cancer
SURE-01 is a neoadjuvant phase 2, open-label, non-randomized, singlecohort study in patients with urothelial carcinoma of the bladder. Patients will be consecutively enrolled and treated.
- Trial name
- NCT05226117
- Testing
- Sacituzumab govitecan
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS San Raffaele
Renal Tumors
Targeted Decision Making In Renal Cell Carcinoma Relying on a Radiogenomics Translational Platform
This project aims to provide an accurate strategy to guide the decision making relying on tumor biopsies using standard histology, immunohistochemistry (IHC), spatial transcriptomics, genomics combined with Magnetic Resonance…
- Trial name
- TARGET-RCC (NCT06868927)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Sphincter (Anal); Perineal Rupture, Obstetric
Digital Rectal Examination vs Machine Learning-assisted Electrical Impedance Spectroscopy for Obstetric Anal Sphincter Injuries' Detection: a Prospective Cohort Study in Primiparous Women Giving Vaginal Childbirth
The investigator will evaluate the detection rate for Obstetric Anal Sphincter Injuries (OASI) in primiparas having given vaginal childbirth, comparing the sensitivity of methods available in a labour ward setting for rapid…
- Trial name
- NCT07474012
- Testing
- Primiparous women who have completed vaginal delivery will be submitted to a digital rectal examination and an examination with machine learning-assisted electrical impedance spectroscopy
- Volunteers
- 110 people
- Sponsor
- IRCCS San Raffaele
Stress Urinary Incontinence (SUI)
Efficacy and Safety of Intravaginal EMS Treatments in Women With Exclusive or Predominant Stress Urinary Incontinence
The investigator wants to evaluate the efficacy of a specific intravaginal Electrical Muscle Stimulation (EMS), in the treatment of exclusive or predominant stress urinary incontinence (SUI) symptoms in women.
- Trial name
- STONE (NCT07466537)
- Testing
- Electrical intravaginal muscle stimulation
- Volunteers
- 15 people
- Sponsor
- IRCCS San Raffaele
Renal Calculi
FANS vs Standard Ureteral Access Sheath in fURS
This is a prospective, interventional single blinded, randomized, single-center study designed to compare the efficacy of a ureteral access sheath with integrated suction (FANS) versus a standard ureteral access sheath (UAS) in…
- Trial name
- CLEAR-URS (NCT07463157)
- Testing
- Standard ureteral access sheath, Flexible and Navigable Suction (FANS) Ureteral Access Sheath
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- IRCCS San Raffaele
Eosinophilic Esophagitis (EoE)
BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY)
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disorder of the esophagus that can lead to symptoms such as dysphagia and food impaction.
- Trial name
- ESCAPE (NCT07102329)
- Where
- Italy
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Bone Remodeling, Energy Metabolism
Retrospective Monocentric Evaluation of Biomarkers Associated With Bone, Muscle and Energy Metabolism
Bone is a metabolically active tissue undergoing continuous remodeling through the coordinated actions of osteoclasts (resorption), osteoblasts (formation), and osteocytes (regulation).
- Trial name
- OVAD (NCT07454252)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Sarcopenia, Sarcopenia in Elderly
Acute Sarcopenia in Hospitalized Older Adults
Acute sarcopenia is a rapid decline in muscle mass and function occurring within 28 days of a major stressor, such as hospitalization, infection, or surgery. It is frequent but often underdiagnosed in older adult.
- Trial name
- BASIS (NCT07454759)
- Testing
- Acute sarcopenia will be defined as the incidence of sarcopenia compared to baseline measurements at recruitment, using the European Working Group on Sarcopenia in older people 2 (EWGSOP2) criteria
- Volunteers
- 280 people
- Sponsor
- IRCCS San Raffaele
Alzheimer Dementia (AD), Mild Cognitive Impairment (MCI)
Making Antibody Treatments More Effective in Early Alzheimer's Disease Using 3Tesla Magnetica Resonance
Alzheimer's disease causes progressive memory and cognitive decline, driven in part by the buildup of a protein called β-amyloid in the brain.
- Trial name
- NCT07456462
- Testing
- MRI assessment and blood sample collection
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Trigeminal Neuralgia, Trigeminal Nerve Diseases
Artificial Intelligence to Predict Surgical Outcomes and Assess Pain Neuromodulation in Trigeminal Neuralgia Subjects
Trigeminal neuralgia (TN) is the most common cause of facial pain. Medical treatment is the first therapeutic choice whereas surgery, including Gamma Knife radiosurgery (GKRS), is indicated in case of pharmacological therapy…
- Conditions
- Trigeminal Neuralgia, Trigeminal Nerve Diseases, Virtual Reality, Artificial Intelligence
- Trial name
- NCT05810428
- Testing
- GKRS-VR training, Control Group
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Alzheimer Disease (AD)
Generation of Synthetic [18F]FDG PET From Early-Phase Amyloid PET in Alzheimer's Disease
This study aims to test a new artificial intelligence (AI) method to create brain scan images without needing an extra scan. Currently, patients with memory problems often undergo two types of PET scans (Amyloid PET and FDG PET)…
- Trial name
- NCT07431255
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- IRCCS San Raffaele
Neck Pain, Chronic Pain
Virtual Reality Rehabilitation in Neck Pain Subjects
VR-NECKPAIN is a two-arm, monocentric, single-blind, randomized controlled trial in Neck Pain patients. The entire treatment consist in 12 sessions, each during 45 minutes, twice a week for 6 consecutive weeks.
- Conditions
- Neck Pain, Chronic Pain, Whiplash
- Trial name
- NCT03987334
- Testing
- Virtual Reality Treatment, Control Group
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Soft Tissue Infections, Mediastinitis
Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections.
The goal of this observational study is to measure how well the antibiotic delafloxacin penetrates into the blood and various body tissues in adult patients over 18 years old.
- Conditions
- Soft Tissue Infections, Mediastinitis, Osteomyelitis/Septic Arthritis, Prosthetic Joint Infection
- Trial name
- DELA-PLAT (NCT07426471)
- Testing
- delafloxacin
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
No Disease or Condition is Being Studied
Optimizing Operational Parameters for Diagnostic Vitrectomy
Single-center ex-vivo study using blood samples from healthy donors processed through a 25-gauge vitrectomy system. The study compares four combinations of operational parameters (vacuum pressure and cut rate) to evaluate their…
- Trial name
- CELLVIT (NCT07408466)
- Testing
- Simulated vitrectomy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
PCNSL
Real World Data on Ibrutinib Use in PCNSL Rel/Ref
PCNSL is a rare and aggressive subtype of B lymphoma that has been recognized as a distinct disease entity in the latest edition of the WHO Classification of Tumors of Haematopoietic and Lymphoid Tissue and is defined as DLBCL…
- Trial name
- ReWIPretro (NCT05782374)
- Testing
- Ibrutinib
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- IRCCS San Raffaele
ADHD - Attention Deficit Disorder With Hyperactivity, Specific Learning Disorder
White Noise in SLD and ADHD
White noise has been shown to improve working memory and attention in children diagnosed with ADHD . These cognitive abilities are fundamental to the acquisition of reading and writing skills.
- Conditions
- ADHD - Attention Deficit Disorder With Hyperactivity, Specific Learning Disorder, Specific Learning Disability
- Trial name
- WHITE NOISE (NCT07376902)
- Testing
- White noise, No white noise
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele Roma
Hypertension, Coronary Artery Disease
Effects of Different Exercise Training Programs on Short-term Blood Pressure Variability and Atrial Function in Hypertension
The study aim is to compare the effects produced by two different exercise training modalities on short-term blood pressure variability and atrial function evaluated by speckle-tracking echocardiography in hypertensive patients…
- Trial name
- TACITO (NCT04763629)
- Testing
- Physical exercise
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele Roma
MCI, MCI Conversion to Dementia
Neurocognitive Assessment Platform 4 Alzheimer
The aging population in Europe is leading to an increase in neurodegenerative diseases, such as Alzheimer's disease (AD), which is expected to affect 152 million people worldwide by 2050.
- Conditions
- MCI, MCI Conversion to Dementia, AMCI - Amnestic Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NAP4A2020 (NCT07272811)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis (UC)
Accuracy of Modified Milan Ultrasound Criteria in Assessing Disease Activity and Severity in Moderate-to-Severe Ulcerative Colitis: a Pilot Study
Longitudinal prospective monocentric observational study in which patients to start Mirikizumab for normal clinical practice will be followed for 24 weeks.
- Trial name
- NCT07358923
- Volunteers
- 25 people
- Sponsor
- IRCCS San Raffaele