Clinical trials: sponsored by IRCCS San Raffaele
Retinal Degenerations, Retinitis Pigmentosa (RP)
Inherited Retinal Diseases: Natural History and Genotype-Phenotype Correlations
Inherited Retinal Diseases (IRDs) are a heterogeneous group of genetically based degenerative retinal disorders, representing a major cause of visual impairment and blindness in working-age adults.
- Conditions
- Retinal Degenerations, Retinitis Pigmentosa (RP), Stargardt Disease
- Trial name
- IRDs-OSR (NCT07265895)
- Testing
- No Intervention: Observational Cohort
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Parkinson Disease
Comparison of Different Non-invasive Electrical Stimulation Protocols to Facilitate Rehabilitation in Parkinson's Disease Subjects With Postural Instability and Gait Disorders
The trial will include 51 adult participants with Parkinson's disease and postural instability and gait disorders (PD-PIGD) and 20 age- and sex-matched healthy controls.
- Trial name
- NCT06868160
- Testing
- Rehabilitation, tDCS, tsDCS (first cycle)
- Where
- Italy
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Smokers
Effect of Smoking on Retinal Vessel Morphology and Functionality
The study aims at evaluating the effect of smoking activity on anatomy and functionality of retinal blood vessels using optical coherence tomography angiography (OCT-A) and dynamic vessel analysis (DVA).
- Trial name
- NCT07261176
- Testing
- Cigarette Smoking
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
IPMN, Pancreatic
Integration of Multiomics Markers for Invasive IPMNs Identification Through the Set-up of the INvasive Cyst bIomarkers Detection (INCITE) Consortium
Although intraductal papillary mucinous neoplasms (IPMNs) represent potential precursors of pancreatic cancer, IPMNs with invasive cancer are rare.
- Trial name
- INCITE (NCT06694792)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS San Raffaele
Endometriosis, Adenomyosis
Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis
This study is a multicentric, observational, case-control, non-profit with additional procedures. It aims to deepen the understanding of the chronic gynecological conditions of endometriosis and adenomyosis, which significantly…
- Trial name
- AdEnd (NCT06572852)
- Testing
- No intervention
- Where
- 2 sites in Italy
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Primary and Secondary Brain Tumors
Integrated PET/MR Imaging With Amino Acid Radiotracers in the Evaluation of Brain Neoplasms: Assessing Diagnostic Accuracy and Therapeutic Response
Evaluation of the diagnostic and prognostic role of PET with Amino Acid Radiotracers associated with simultaneous acquisition of MRI with administration of paramagnetic contrast medium based on Gadobutrol in assessing diagnostic…
- Trial name
- PETMR_ATHENA02 (NCT07211360)
- Volunteers
- 270 people
- Sponsor
- IRCCS San Raffaele
Infertility (IVF Patients)
Machine Learning and Pregnancy Success Prediction in Fertility Treatments
Infertility, as defined by the World Health Organization (WHO), is a disorder of the male or female reproductive system characterized by the inability to achieve a clinical pregnancy after 12 months or more of regular…
- Trial name
- MaLIV-PMA (NCT06884930)
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- IRCCS San Raffaele
Oocyte Cryopreservation
Optimization of Oocyte Warming Protocols
This is a retrospective study with a sibling design comparing new oocyte thawing protocols (rapid and ultra-rapid) with the traditional method
- Trial name
- OVOfast (NCT07105891)
- Testing
- Thawing protocol
- Where
- Italy
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Diabetes, Metabolic Disorders
Observational Study for the Characterisation of Patients Affected by Any Type of Diabetes and Endocrine Disorders
The main objective of this retrospective and prospective observational register is to identify anthropometric, clinical, laboratory and/or instrumental markers of disease severity and activity in patients suffering from diabetes…
- Conditions
- Diabetes, Metabolic Disorders, Arterial Hypertension, Dyslipidemia
- Trial name
- DiabRegistry (NCT07206875)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Cancer, Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)
Immune Adverse Events Registry in Onco-Hematologic Patients Treated With Immunotherapy
Immunotherapy is a therapeutic strategy aimed at inducing the immune system to identify and combat cancer cells and, alongside the evident clinical success observed in many patients, a specific toxicity profile has emerged…
- Conditions
- Cancer, Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Cancer (Solid Tumors), Cancer (With or Without Metastasis)
- Trial name
- MITOX (NCT07198958)
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Head Trauma
Single-center Transversal Observational Study on the Evaluation of S100B Changes in Subjects Attending the Emergency Department With Head Trauma
The aim of the study is to evaluate blood levels of the calcium-binding protein S100B as a diagnostic biomarker for the management of patients with suspected traumatic brain injury.
- Trial name
- NCT07036146
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis (UC)
Comparative Outcomes of Ulcerative Colitis Patients With Mayo Endoscopic Score 1 and Histologic Activity Versus Mayo Endoscopic Score 2
This retrospective study examines patients with ulcerative colitis who initiated advanced therapy for their disease. In clinical practice, patients with only mild inflammation on endoscopy (Mayo Endoscopic Subscore 1, or MES1)…
- Trial name
- NCT07188727
- Where
- Italy
- Volunteers
- 159 people
- Sponsor
- IRCCS San Raffaele
Chronic Granulomatous Disease X-linked (X-CGD)
Combination of Ibuprofen, G-CSF and Plerixafor as Stem Cells Mobilization Regimen in Patients Affected by X-CGD
This is a phase II exploratory study conducted to evaluate the safety and efficacy of the combination of Ibuprofen, G-CSF and Plerixafor as stem cell mobilization regimen in patients affected by X-CGD.
- Trial name
- XCGD-MOBI (NCT03055247)
- Testing
- Ibuprofen, Myelostim, Mozobil
- Where
- 2 sites in Italy
- Volunteers
- 3 people
- Sponsor
- IRCCS San Raffaele
Deep Venous Disease of the Lower Limbs
European Venous Registry
The European Venous Registry (EVeR) is an international repository of data on the treatments and outcomes of people with deep venous disease.
- Trial name
- EVeR (NCT06906250)
- Where
- 10 sites in France, Germany and 7 more
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
PROMs
Patient Reported Outcome Measurements (PROMs) Impact on Clinical Outcome in firsT Line settIng Non- Small-Cell Lung Cancer (NSCLC) According to Chemo- Immunotherapy reGimen
A multicenter, national pharmacological observational study that has as its overall goal to implement a set of validated and agreed upon European-wide questionnaires (PROMs - patient's reported outcomes) to assess patients'…
- Trial name
- PROMOTING (NCT07061379)
- Testing
- Carboplatin/Cisplatin+Pemetrexed+Pembrolizumab/Cemiplimab for 4 cycles and then maintenance with Pemetrexed+Pembrolizumab/Cemiplimab up to 2 years or disease progression or unacceptable toxicity, Carboplatin/Cisplatin+Pemetrexed+Nivolumab+Ipilimumab for 2 cycles and then maintenance with Nivolumab q21 and Ipilimumab q42 up to 2 years or disease progression or unacceptable toxicity
- Where
- Italy
- Volunteers
- 144 people
- Sponsor
- IRCCS San Raffaele
Urinary Incontinence, Experience, Life
Living With Urinary Incontinence: Women's Experiences in a Qualitative Phenomenological Study
Study Description: Scientific literature demonstrated the negative influence of Urinary Incontinence (UI) on the quality of life connected to the physical, psychological, and social health of women.
- Trial name
- LEI (NCT06421428)
- Testing
- LEI Interview, LEI Survey
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Neoplasms, Distal Pancreatectomy (DP)
Feasibility and Effectiveness of Three-day Discharge After Distal Pancreatectomy
Background: Enhanced recovery after surgery (ERAS) programs and the minimally invasive approach have significantly improved recovery outcomes following distal pancreatectomy (DP).
- Trial name
- 3DD (NCT07095621)
- Testing
- 3 days discharge
- Volunteers
- 35 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer, Periampullary Cancer
Prehabilitation in Pancreatic Surgery
In patients with pancreatic cancer, older age, multiple comorbidities, frailty, malnutrition and poor functional status are common, especially in individuals receiving neoadjuvant chemotherapy.
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Frailty Syndrome, Malnutrition
- Trial name
- PIPS (NCT06069297)
- Testing
- Multimodal Prehabilitation
- Where
- Italy
- Volunteers
- 238 people
- Sponsor
- IRCCS San Raffaele
Breast Cancer Female, Node-positive Breast Cancer
Axillary Staging in Node Positive Breast Cancer Patients Receiving PST. SNB vs PET/MRI
The management of axillary nodes in breast cancer patients is a highly debated and evolving field. To date, an increasing number of patients with positive lymph nodes receives primary systemic therapy (PST) prior to surgery…
- Conditions
- Breast Cancer Female, Node-positive Breast Cancer, Sentinel Lymph Node
- Trial name
- NCT04826211
- Testing
- PET/MRI
- Where
- Italy
- Volunteers
- 109 people
- Sponsor
- IRCCS San Raffaele
Eosinophilic Esophagitis
Prospective Registry of EoSinophilic esOphagitis
This is a prospective registry of all the Eosinophilic Esophagitis (EoE) patients referred to the third level referral centre of San Raffaele Scientific Institute
- Trial name
- PRESO (NCT06443346)
- Testing
- Eosinophilic Esophagitis
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele