Clinical trials: sponsored by Imperial College London
Diabetes Mellitus
Oral Propionate to Treat and Prevent Diabetes
The aim of these studies is to firstly determine the pharmacokinetic profile of orally administered enteric coated sodium propionate.
- Trial name
- NCT01692002
- Testing
- Sodium propionate, Sodium Chloride, Oral glucose tolerance test
- Where
- 3 sites in United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Prostate Cancer, Non-metastatic Prostate Cancer
PROState Pathway Embedded Comparative Trial
The proposal will explore a trial design called the cohort-multiple RCT (cmRCT) or as it has been recently coined, the Trials WithIn Cohorts (TWICS) design.
- Conditions
- Prostate Cancer, Non-metastatic Prostate Cancer, Metastatic Prostate Cancer, Prostate Adenocarcinoma
- Trial name
- IP3-PROSPECT (NCT04400656)
- Where
- 3 sites in United Kingdom
- Volunteers
- 139 people
- Sponsor
- Imperial College London
Covid19, SARS-CoV Infection
SARS-CoV-2 Human Challenge Characterisation Study
This is a dose optimisation study in healthy adults aged 18-30 who will be experimentally inoculated with SARS-CoV-2. The aim is to cause PCR-confirmed upper respiratory infection in the majority of challenged individuals with…
- Conditions
- Covid19, SARS-CoV Infection, Corona Virus Infection, Coronavirus
- Trial name
- NCT04865237
- Testing
- SARS-CoV-2 Virus 1x10^1 TCID50, Remdesivir, SARS-CoV-2 Virus 1x10^2 TCID50
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Varicose Veins
Pilot RCT Evaluating a One Stop Vein Clinic
A pilot randomised controlled trial looking at the setting up of a one stop vein clinic for the treatment of varicose veins and assessing the quality-adjusted life years at 3 months of patients This will be a pilot study which is…
- Trial name
- OSVeC (NCT02557542)
- Testing
- One Stop Vein Clinic, Radiofrequency ablation, Endovenous laser ablation
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Imperial College London
Neuroendocrine Tumors
Evaluation of [18F]Fluoroethyl Triazole Labelled [Tyr3]-Octreotate Analogues for the Imaging of Neuroendocrine Tumours.
Radiolabelled somatostatin analogs are invaluable in the diagnosis and treatment of neuroendocrine tumours (NET). The most common positron emission tomography (PET) radiotracers used for the visualisation of NET are radiolabelled…
- Trial name
- FETONET (NCT06456723)
- Testing
- [18F]-FET-βAG-TOCA
- Volunteers
- 56 people
- Sponsor
- Imperial College London
Gut Health
Investigation of the Effects of Dietary Fibres on the Gut Microbiome in a Transgenerational Cohort
Dietary fibres are complex carbohydrates present in fruit, vegetables, grains, and beans which are broken down into smaller molecules (short-chain fatty acids) in the colon by the gut microbiota.
- Trial name
- NCT05364437
- Testing
- Dietary Fibres Supplement, Cellulose Control
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Self Injurious Behavior, Adolescent Behavior Problem
IMAGINATOR 2.0: Co-design and Early Evaluation of a Novel Blended Digital Intervention Targeting Self-harm in Young People
This study aims to investigate acceptability and feasibility of a new version of the Imaginator intervention, Imaginator 2.0, targeting self-harm behaviour in young people aged 12-25 under mental health services in the UK.
- Conditions
- Self Injurious Behavior, Adolescent Behavior Problem, Child Behavior Problem, Mental Health Disorder
- Trial name
- IMAG2 (NCT06311084)
- Testing
- Imaginator 2.0
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- Imperial College London
Cerebral Metastases
Measuring Fatty Acid Oxidation in Cerebral Metastases Using [18F]FPIA
Cerebral metastases represent a significant problem for oncological management. It is estimated that 20-40% of patients with cancer will develop metastatic cancer to the brain during the course of their illness.
- Trial name
- NCT04807582
- Testing
- [18F]FPIA PET/MRI
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Imperial College London
Prostate Cancer, Non-metastatic Prostate Cancer
Comparative Health Research Outcomes of NOvel Surgery in Prostate Cancer
Men diagnosed with significant cancer confined to the prostate currently undergo radical therapy directed to the whole prostate (radiotherapy or prostatectomy).
- Conditions
- Prostate Cancer, Non-metastatic Prostate Cancer, Prostate Adenocarcinoma
- Trial name
- IP4-CHRONOS (NCT04049747)
- Testing
- Radical therapy (radiotherapy or prostatectomy [radiotherapy can be external beam or brachytherapy], Focal therapy, Focal therapy after Finasteride 5Mg tablets for 12 weeks
- Where
- 10 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Behavior
RxConnect User Testing Study
Background Medication errors are the leading cause of preventable harm in healthcare settings worldwide. An estimated 237 million medication errors occur in England alone every year, with 66 million considered clinically…
- Trial name
- NCT05493072
- Testing
- RxConnect
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity
Investigation of a New Diet for the Treatment of Obesity in the NHS
Over one in four adults living in the UK is living with obesity. Obesity is associated with health complications including type 2 diabetes, heart disease and depression.
- Trial name
- NCT05249439
- Testing
- I-SatPro weight loss programme, Tier 3 weight loss programme
- Volunteers
- 21 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Obesity
Study of the Gut Hormone Analogue Y14 in Adult Subjects
A randomised, placebo controlled Phase I study to investigate investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of Y14 in adult subjects.
- Trial name
- NCT03673111
- Testing
- Y14
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Alcoholic Hepatitis
IL-1 Signal Inhibition in Alcoholic Hepatitis
Alcoholic hepatitis (AH) is a florid presentation of alcoholic liver disease characterized by liver failure in the context of recent and heavy alcohol consumption.
- Trial name
- ISAIAH (NCT03775109)
- Testing
- Canakinumab 150mg/ml solution for injection
- Where
- 16 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- Imperial College London
Primary Liver Carcinoma
Study of Pembrolizumab Following TACE in Primary Liver Carcinoma
Open label, single arm, multi-centre study of pembrolizumab following trans-arterial chemoembolization (TACE). Twenty-six to 32 evaluable participants with primary liver cancer (hepatocellular cancer; HCC) will be assessed.
- Trial name
- PETAL (NCT03397654)
- Testing
- Pembrolizumab, Trans-arterial chemoembolization
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Metformin to Reduce Airway Glucose in COPD Patients
Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death worldwide and affects 1.2 million people in the UK, costing the NHS >£800 million annually.
- Trial name
- NCT03651895
- Testing
- Metformin
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Imperial College London
Human Influenza, Respiratory Syncytial Virus Infections
Evaluation of a Single Use Point of Care Device for the Diagnosis of Respiratory Pathogens
This study evaluates a single use point of care diagnostic test in the diagnosis of influenza and other respiratory viral infections in adults. Participants will have a sample taken from their nose using a swab.
- Conditions
- Human Influenza, Respiratory Syncytial Virus Infections, Rhinoviral Infections, Enterovirus Infections
- Trial name
- SIMPLIFI (NCT04431050)
- Testing
- Point of care testing of respiratory viruses.
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Imperial College London
Asthma in Children, Medication Adherence
Financial Incentives to Improve Asthma
The aim of this pilot randomised controlled trial is to assess the effectiveness of a short-term financial incentives intervention at bringing about behaviour change, namely short-medium term improvements in inhaled…
- Trial name
- FINA (NCT05322044)
- Testing
- Financial incentives
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Imperial College London
Heart Failure
The His Optimised Pacing Evaluated for Heart Failure Trial (HOPE-HF).
This is a multi-centre, prospective randomised double-blinded cross over study, recruiting a sub-population of patients with heart failure.
- Trial name
- HOPE-HF (NCT02671903)
- Testing
- Pacemaker: AV optimised, His pacing.
- Where
- 15 sites in United Kingdom
- Volunteers
- 198 people
- Sponsor
- Imperial College London
HIV
Safety and Immunogenicity of HIV DNA-C CN54ENV and Recombinant HIV CN54gp140 Vaccines in Healthy Volunteers
CUTHIVAC002 is a randomised Phase I study aimed at exploring the safety and immunogenicity of two different modes of delivery of a deoxyribonucleic acid (DNA) vaccine (DNA-C CN54ENV) via combined intramuscular and intradermal…
- Trial name
- NCT02589795
- Testing
- DNA-C CN54ENV, CN54gp140, Trigrid Delivery System - Intramuscular
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Breast Cancer
Behavioural Science Messages in Breast Cancer Screening
Breast cancer is the most common cancer in the United Kingdom, with 1 in 8 women affected during their lifetime. Whilst survival rates are high, the 5-year survival rate is 72% higher with the earliest stage breast cancer…
- Trial name
- NCT05395871
- Testing
- Behavioural Message, Behavioural Message + Video, Usual Care Message
- Where
- United Kingdom
- Volunteers
- 34,047 people, healthy volunteers welcome
- Sponsor
- Imperial College London