Clinical trials: open to volunteers, sponsored by Imperial College London
Adenocarcinoma of the Rectum
Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits
Any patient with a suspected primary adenocarcinoma of the colon, sigmoid or rectum undergoing surgery are eligible. The date of surgery must be known prior to registration.
- Trial name
- COMET (NCT03303547)
- Testing
- MRI mapping to guide pathological sampling of extranodal tumour deposits
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Multiple Sclerosis
Validation of the 18 kiloDalton Translocator Protein (TSPO) as a Novel Neuroimmunodulatory Target
In multiple sclerosis (MS) cells of the immune system attack the brain causing tissue damage. In secondary progressive MS (SPMS) these repeated immune attacks have stopped but despite this new damage continues to appear.
- Trial name
- TSPO (NCT03850301)
- Testing
- XBD173, Etifoxine
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Pulmonary Arterial Hypertension, Healthy
Quantifying 18kDa TSPO Expression in the Lung in Pulmonary Artery Hypertension (PAH)
The aim of this study is to determine whether there is an increase in the TSPO PET signal (measured with the radioligand [11C]PBR28) in the lungs of patients living with PAH relative to age matched controls.
- Trial name
- NCT05745961
- Testing
- TSPO PET scan (11C-PBR28)
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Imperial College London
Neuromuscular Diseases, Neurodevelopmental Disorders
Nebulised Hypertonic Saline to Decrease Respiratory Exacerbations in Neuromuscular Disease or Neurodisability
Research Aim: This study investigates whether a 12-month treatment with hypertonic saline (salty water) can reduce antibiotic use in individuals with neuromuscular disease or cerebral palsy who frequently experience chest…
- Conditions
- Neuromuscular Diseases, Neurodevelopmental Disorders, Cerebral Palsy
- Trial name
- SPICE-UP (NCT06134401)
- Testing
- saline
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College London
Cerebral Small Vessel Disease
Targeting 18kDa Translocator Protein (TSPO) to Improve Brain Endothelial Cell Function in Cerebral Small Vessel Disease
In healthy people, blood flow to particular areas in the brain increases when the area becomes more active. This ensures that the brain gets enough blood at the right place and time.
- Trial name
- NCT06643013
- Testing
- XBD173
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Steroid-Induced Diabetes, Steroid Induced Hyperglycemia
The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes
TITLE: How GLP-1 Analogues prevent steroid-induced diabetes (The GAPSID Study) DESIGN: A double-blind study evaluating how GLP-1 analogues, compared with metformin, prevent hyperglycaemia in response to a 7-day course of…
- Trial name
- NCT06318442
- Testing
- Semaglutide Oral Product, Metformin Oral Tablet
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Fertility Disorders, Hypothalamic Dysfunction
Reproductive Hormones During Sustained Administration of Kisspeptin
We want to find out what happens to reproductive hormone levels; Luteinising Hormone (LH), Follicle Stimulating Hormone (FSH), testosterone and oestradiol when kisspeptin is administered to people for a period of 8 days each…
- Trial name
- KisspeptPump (NCT02081924)
- Testing
- Kisspeptin 0.1, Saline, Kisspeptin 0.3
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Spine Fusion, Spine Injury
Spine Surgery Video Observation Study. The Creation of a Benchmark Video (RGB-Depth) Dataset to Investigate the Feasibility of Developing a Markerless Tracking System for Spine Surgery.
The primary study objective is to build a video dataset, consisting of both colour and depth information, of spine surgery that includes both 'open' and 'minimally invasive' (MIS) surgeries.
- Conditions
- Spine Fusion, Spine Injury, Spine Degeneration, Navigation, Spatial
- Trial name
- SPIVOS (NCT06580379)
- Testing
- Spine surgery
- Volunteers
- 25 people
- Sponsor
- Imperial College London
Breast Cancer
HERPET- A Novel PET Imaging Study of HER2 in Breast Cancer
This mechanistic study will be the first study to assess the efficacy of [18F]GE-226 to target HER2 expression in patients with metastatic breast cancer.
- Trial name
- NCT03827317
- Testing
- [18F]GE-226
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Imperial College London
Pregnancy Complications, Gestational Diabetes
Early Versus Late Monitoring Among Pregnant Women With a History of Gestational Diabetes
The goal of this study investigate if pregnant women with a history of gestational diabetes (GDM) have better pregnancy outcomes if they test their blood glucose four times a day early in the pregnancy versus having an oral…
- Trial name
- NCT06545227
- Testing
- continuous blood glucose monitoring in a subset of women (n=25) in the early monitoring group., Collection of urine, maternal blood at baseline and 28 weeks in a subset of women (n=25), Collection of umbilical cord blood, placental samples and cord tissue in a subset of women (n=25)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Prostate Cancer
Comparing pOrtable MRI and TRUS-Fusion Prostate Biopsy to Assess aCcuracy of Prostate Cancer Detection
Currently, patients suspected of having prostate cancer undergo an MRI followed by targeted biopsies of any suspicious lesions under trans-rectal ultrasound (TRUS) guidance. This pathway is labour, time, and cost-intensive.
- Trial name
- IP10-COMPACT (NCT06453785)
- Testing
- Promaxo portable MRI
- Where
- United Kingdom
- Volunteers
- 85 people
- Sponsor
- Imperial College London
Infections, Bacterial, Pharmacokinetics
Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment
The primary aim of the study is to determine the proportion of individuals receiving beta-lactam antibiotics at Imperial College Healthcare NHS Trust in whom drug concentration targets are achieved.
- Conditions
- Infections, Bacterial, Pharmacokinetics, Drug Monitoring, Drug-Related Side Effects and Adverse Reactions
- Trial name
- DATATDM (NCT06427317)
- Where
- United Kingdom
- Volunteers
- 323 people
- Sponsor
- Imperial College London
Atrial Fibrillation, Atrial Fibrillation, Persistent
Ablation of Focal Activation in Atrial Fibrillation
Recurrent focal electrical activation (or ectopy) superseding sinus activation is the only mechanism proven to drive paroxysmal atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Atrial Fibrillation, Persistent, Arrhythmia, Arrhythmias, Cardiac
- Trial name
- RETRO-AF (NCT06402617)
- Testing
- Pulmonary vein isolation, RETRO-Mapping without adjunctive ablation, Adjunctive ablation guided by RETRO-Mapping
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Imperial College London
HIV/AIDS and Infections
A Randomised Placebo Controlled Trial of ART Plus Dual Long-acting HIV-specific Broadly Neutralising Antibodies (bNAbs).
RIO is a placebo-controlled double-blinded two arm prospective phase II randomised controlled trial . This study will test the use of broadly neutralising antibodies (bNAbs) in participants with treated primary HIV infection…
- Trial name
- RIO (NCT04319367)
- Testing
- Investigational Medicinal Product
- Where
- 12 sites in Denmark, United Kingdom
- Volunteers
- 72 people
- Sponsor
- Imperial College London
Germ Cell Ovarian Cancer, Germ Cell Tumor
SerUm and Plasma MicroRNAs in Malignant Ovarian gERm Cell Tumours
The goal of this observational case-control study is to learn about the circulating and tissue microRNA expression, imaging and radiomic profiles of malignant ovarian germ cell tumours (MOGCT) compared to patients with a benign…
- Conditions
- Germ Cell Ovarian Cancer, Germ Cell Tumor, Germ Cell Cancer, Germ Cell Neoplasia
- Trial name
- SUMMER (NCT06329323)
- Testing
- Blood test, Pathology specimen miRNA expression
- Volunteers
- 24 people
- Sponsor
- Imperial College London
Encephalopathy, Erythropoietin
Erythropoietin for Neonatal Encephalopathy in LMIC (EMBRACE Trial)
One million babies die, and at least 2 million survive with lifelong disabilities following neonatal encephalopathy (NE) in low and middle-income countries (LMICs), every year.
- Conditions
- Encephalopathy, Erythropoietin, Newborn Asphyxia
- Trial name
- EMBRACE (NCT05395195)
- Testing
- Erythropoietin, Supportive neonatal intensive care
- Where
- 10 sites in Bangladesh, India and 1 more
- Volunteers
- 504 people
- Sponsor
- Imperial College London
Lung Cancer, Nonsmall Cell
A Randomised Open-label Phase III Trial of REduced Frequency Pembrolizumab immuNothErapy for First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
REFINE-lung will test whether reduced pembrolizumab dose frequency after 6 months of standard treatment is safe and effective. Patients treated with 1st line pembrolizumab who are progression free and otherwise planning to…
- Trial name
- REFINE-Lung (NCT05085028)
- Testing
- Pembrolizumab 25 MG/ML [Keytruda]
- Where
- 37 sites in United Kingdom
- Volunteers
- 1,750 people
- Sponsor
- Imperial College London
Cardiomyopathies, Hypertrophic Cardiomyopathy
The SMARTER Cardiomyopathy Study
Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses.
- Conditions
- Cardiomyopathies, Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy
- Trial name
- SMARTER-CM (NCT05750147)
- Testing
- Blood Sample Collection
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Telangiectasia, Hereditary Hemorrhagic
Molecular Studies on Hereditary Haemorrhagic Telangiectasia Families
This study will examine genes involved in the vascular dysplasia Hereditary haemorrhagic telangiectasia i(HHT)
- Trial name
- NCT00230620
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Telangiectasia, Hereditary Hemorrhagic
Case Notes Review on Patients With Hereditary Haemorrhagic Telangiectasia
This observational study is for individuals with Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations that are reviewed at the Hammersmith Hospital, London.
- Trial name
- NCT00230685
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Imperial College London