Clinical trials: open to volunteers, sponsored by Imperial College London
Cardiac Arrhythmia, Atrial Fibrillation
The Role of Right Atrial Ectopy Triggering Ganglionated Plexuses in AF
Atrial fibrillation (AF) is the most common rhythm disturbance of the heart. It can affect people of any age but usually happens as we get older. It can cause palpitations, breathlessness, lethargy, and fainting attacks.
- Trial name
- RGanglia-AF (NCT05539040)
- Testing
- Right Atrial ganglionated plexus ablation, Holter Monitor, Pulmonary vein isolation
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- Imperial College London
Gastric Cancer, Peritoneal Metastases
Neoadjuvant Systemic and Peritoneal Chemotherapy for Advanced Gastric Cancer
Data demonstrating the efficacy of PIPAC in patients with regionally advanced gastric cancer with positive peritoneal cytology and/or minimal peritoneal disease is limited due to the relatively recent development of this…
- Conditions
- Gastric Cancer, Peritoneal Metastases, Chemotherapy Effect
- Trial name
- SPECTRA (NCT05318794)
- Testing
- Doxorubicin and Cisplatin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Stroke, Stroke (CVA) or TIA
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors.
- Conditions
- Stroke, Stroke (CVA) or TIA, Dementia, Vascular, Cerebrovascular Disorders
- Trial name
- IC3 (NCT05885295)
- Testing
- MRI brain, Blood tests, cognitive assessments
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes Mellitus, Type 2, Obesity
Who Will Benefit From Bariatric Surgery for Diabetes?
A study investigating the influence of fat distribution, genetic susceptibility markers for type 2 diabetes (T2DM) and fat distribution, epigenetic and transcriptomic changes and gut hormone responses to a mixed meal on diabetes…
- Trial name
- NCT03842475
- Testing
- Roux-en-Y gastric bypass (RYGB)
- Where
- United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity, Type 2 Diabetes
Medication Following Bariatric Surgery for Type 2 Diabetes Mellitus
The aim of this study is to investigate the continued usage of standard diabetes medications in the post operative period following bariatric surgery to determine whether this approach may improve long term diabetes control.
- Trial name
- BY-PLUS (NCT04432025)
- Testing
- Bariatric surgery + goal directed medical therapy, Bariatric surgery
- Where
- Ireland
- Volunteers
- 150 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Diabetes Mellitus, Type 1
RT-CGM in Young Adults at Risk of DKA
Pilot study to evaluate the effect of real time continuous glucose monitoring (RT-CGM) on young-adults with insulin-treated diabetes, who are defined as high risk due to suboptimal HbA1c (blood glucose control) or a history of…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- YODA (NCT04039763)
- Testing
- Dexcom G6, Self monitoring of blood glucose
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Pulmonary Disease, Chronic Obstructive
The London COPD Exacerbation Cohort
The London COPD exacerbation (EXCEL) cohort builds on an established cohort started in 1995 and designed to study COPD exacerbations and their impact on health-status and disease progression.
- Trial name
- EXCEL_Cohort (NCT02755974)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Imperial College London
Obesity, Type 2 Diabetes
Gut Hormones and Roux en Y Gastric Bypass
The purpose of this study is to assess whether the changes in gut hormones seen following Roux en Y Gastric Bypass surgery are responsible for some of the beneficial effects seen post-operatively.
- Trial name
- NCT01945840
- Testing
- Roux en Y Gastric Bypass Surgery, Gut hormone infusion, Very low calorie diet
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Transplant; Complication, Rejection
Mechanistic Evaluation of Treatments for Acute Antibody-Mediated Rejection of the Kidney Transplant
The best treatment for kidney failure is a kidney transplant, but a transplanted kidney only works for about 10 to 15 years on average.
- Trial name
- MOT-AMR (NCT04496037)
- Testing
- Rituximab
- Volunteers
- 170 people
- Sponsor
- Imperial College London