Clinical trials: sponsored by Indiana University
Preterm Labor With Preterm Delivery, Premature Birth
Pharmacokinetics and Placental Transfer of Caffeine
The goal of this study is to learn how a pregnant person's body processes caffeine and how much caffeine crosses the placenta to the baby. A small dose of caffeine will be given to each pregnant participant before delivery.
- Conditions
- Preterm Labor With Preterm Delivery, Premature Birth, Apnea of Prematurity, Respiratory Distress Syndrome
- Trial name
- AnteCaff (NCT07570121)
- Testing
- Caffeine citrate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Insomnia
Adapted CBT-I for Adolescents With Insomnia : The DREAM-IT Study
The goal of this study is to test an adapted treatment for teen insomnia in comparison to a waitlist condition. Cognitive Behavioral Therapy for Insomnia (CBT-I) is an intervention that was developed for adults and is sometimes…
- Trial name
- NCT06541886
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Indiana University
Chronic Pain, Chronic Pain Syndrome
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain from chronic pancreatitis (CP).
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pancreatitis, Hyperalgesia
- Trial name
- STTEPP (NCT05603702)
- Testing
- Lacosamide
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Indiana University
Cerebellar Disorders, Cerebellar Degeneration
Variable Intense Training for Ataxia and Locomotion
The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar…
- Conditions
- Cerebellar Disorders, Cerebellar Degeneration, Cerebellar Atrophy, Cerebellar Lesions
- Trial name
- VITAL (NCT07621978)
- Testing
- High-intensity training in variable contexts, Conventional balance training
- Volunteers
- 20 people
- Sponsor
- Indiana University
Autism Spectrum Disorder
Effect of Virtual Reality-based Training on Balance and Walking in Youth With Autism Spectrum Disorder
The goal of this clinical trial is to assess the effect of short-term (3 days/week for 2 weeks) Virtual Reality (VR) active video gaming intervention on static and dynamic balance, versus traditional balance training exercises…
- Trial name
- NCT06023563
- Testing
- Virtual reality active video gaming using Nintendo switch sports, Standard physical therapy balance exercises
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Indiana University
Ovarian Aging, Adverse Pregnancy Outcomes
The Bone and hEArt Health Consequences of Ovarian agiNg (BEACON) Study
Ovarian aging is a major driver of a woman's long-term health and disease risk. In particular, the rapid decline in the ovarian reserve that occurs with the menopause transition is linked to a striking increase in the risk for…
- Trial name
- BEACON (NCT07621965)
- Volunteers
- 655 people
- Sponsor
- Indiana University
Motor Activity
Unilateral M1 Anodal tDCS to Enhance Learning in a Gross Movement Videogame Task
Virtual reality as a gaming method is being used more regularly due to its immersive environments and total body playability. A few studies have used VR paired with brain stimulation as a clinical treatment for PTSD (van't…
- Trial name
- NCT07447882
- Testing
- tDCS
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cortical Excitability, Primary Motor Cortex
rTMS Induced Reduction in M1 Excitability
When learning a new skill, much of the improvement comes from small alterations the brain makes with each repetition during practice, but this isn't the only time that improvements are made during the learning process.
- Conditions
- Cortical Excitability, Primary Motor Cortex, Motor Skills
- Trial name
- NCT07588113
- Testing
- rTMS
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Indiana University
Prostate Cancer
CYTALUX™for the Intraoperative Imaging of Prostate Cancer
This study is being done to compare how much using Cytalux™ (pafolacianine) with NIR (Near InfraRed) fluorescent imaging improves the detection of malignant (growing in an uncontrolled way) tissue in adult subjects undergoing…
- Trial name
- NCT06434909
- Testing
- Cytalux™ (pafolacianine) for fluorescent imaging, Image Guided Surgery
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Indiana University
End of Life, Communication
Informational Meetings for Planning and Coordinating Treatment
This prospective cluster-randomized trial examines the efficacy of a novel communication intervention delivered by trained physician and nurse dyads to parents of children with cancer within the clinicians' practice, to foster…
- Conditions
- End of Life, Communication, Cancer Metastatic
- Trial name
- IMPACT (NCT04330833)
- Testing
- Novel Communication Intervention, Enhanced Usual Care Parent Education
- Where
- 7 sites in United States
- Volunteers
- 111 people
- Sponsor
- Indiana University
Breast Cancer
Effect of Low Intensity Vibration (LIV) on Aromatase Inhibitor- Induced Musculoskeletal Dysfunction in Early Stage Breast Cancer Survivors
The purpose of this study is to compare the effect of low intensity vibration (LIV) delivered for 10 minutes twice daily for 12 months on skeletal muscle function, in terms of energetic capacity measured by power generation on a…
- Trial name
- NCT03712813
- Testing
- Macrodyne LivMD plate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Indiana University
Hiv, Transmission Vertical
Differentiated Service Delivery for Pregnant and Postpartum Women Living With HIV and Their Infants
Differentiated service delivery (DSD) is an evidence-based HIV care and treatment model endorsed by the World Health Organization (WHO) that simplifies HIV services for clients who are clinically stable, improving the quality and…
- Conditions
- Hiv, Transmission Vertical, Viremia, Health Care Acceptability
- Trial name
- NCT06629753
- Testing
- Differentiated service delivery model
- Where
- Kenya
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Indiana University
COVID-19, Healthy
A Nasal Treatment for COVID-19
The goal of this study is to test an investigational new inhaled medication called Optate.
- Trial name
- COVD-TX (NCT05799521)
- Testing
- Optate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Coronary Artery Disease
Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease
This is a prospective pilot study to evaluate the safety, tolerability and technical feasibility of utilizing carbon dioxide for assessing coronary blood flow in subjects with coronary artery disease.
- Trial name
- NIMO-CAD (NCT06253884)
- Testing
- RespirAct
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
End Stage Renal Disease (ESRD), Kidney Disease
RaDIANT Health Systems Intervention
The overarching goal of the proposed study is to determine whether the addition of structural interventions at the health system level targeting upstream barriers in the transplant process will improve access to transplant…
- Trial name
- NCT07033117
- Testing
- Performance Feedback Reports on Referral and Evaluation Closures, Dialysis Facility Awareness Campaign, Patient Contact via Preferred Method
- Where
- 5 sites in United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Autism
The Alama Project: Autism Outcomes and Neurobehavioral Markers in Young Children Born to Mothers With HIV in Kenya
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures to determine whether these can predict autism diagnoses in both children exposed to HIV and…
- Trial name
- Alama (NCT06703125)
- Testing
- Eyelink Portable Duo
- Where
- Kenya
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cold Exposure
Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure
This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.
- Trial name
- NCT05822141
- Testing
- Fish Oil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid Use Disorder, Substance-Related Disorders
Maternal Brain Imaging in Opioid Use Disorder
This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved.
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related
- Trial name
- NCT06008990
- Testing
- Buprenorphine, Maternal Brain MRI, Blood Samples
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obstructive Sleep Apnea of Child
Evidence-based Pediatric Obstructive Sleep Apnea Detection
The goal of this clinical trial is to test whether a health communication message (infographic about obstructive sleep apnea; OSA) seen by parents whose children have OSA symptoms will be helpful in identifying children with OSA.
- Trial name
- NCT05908110
- Testing
- Health Communication Message
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Alcohol Use Disorder
Sex Differences in the Response to Abstinence From Alcohol.
In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that…
- Trial name
- SPAR (NCT03827460)
- Testing
- Abstinence from alcohol, Usual drinking, Intravenous Alcohol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
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