Clinical trials: sponsored by Indiana University
Diabetes, Hyperglycemia
Monitoring Exhaled Breath to Noninvasively Detect Glycemic Events
The purpose of this study is to determine whether an array of biosensors can noninvasively identify hyperglycemic or hypoglycemic events in persons diagnosed with diabetes through noninvasive detection of volatile organic…
- Conditions
- Diabetes, Hyperglycemia, Hypoglycemia
- Trial name
- NCT06893341
- Testing
- The Sensing Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Exercise Induced Bronchospasm, Exercise Induced Asthma
Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)
Due to the lack of studies examining the impact of inspiratory muscle training (IMT) on the severity of exercise-induced bronchoconstriction (EIB) and exercise performance, the specific aim of this study is to assess the efficacy…
- Trial name
- IMT_EIB (NCT06336681)
- Testing
- PrO2Fit Device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Autism, Neurodevelopment
Reciprocal Innovation to Optimize Low-Tech Augmentative and Alternative Communication (AAC) for Individuals
Many people with autism and other developmental conditions have difficulty speaking or do not use speech and need other ways to communicate.
- Trial name
- AAC (NCT07581483)
- Testing
- Automated AAC Assessment and Low-Tech AAC Implementation Support, Standard AAC Support
- Where
- 2 sites in United States, Kenya
- Volunteers
- 500 people
- Sponsor
- Indiana University
Intervention Group, Treatment as Usual
Caring for Caregivers of Individuals With Alzheimer's Disease
What is this study about? This study is called the EMBRACE Study - A Virtual Community Empowerment Approach Integrating Tradition and Technology for Family Caregivers of Individuals with Alzheimer's Disease.
- Trial name
- NCT07486037
- Testing
- Exercise
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dry Eye
Comparative Assessment of Lipid Layer Thickness Measurements
This study compares ocular lipid layer thickness (LLT) measurements obtained from three commonly used clinical diagnostic devices to evaluate their agreement and consistency.
- Trial name
- NCT07579130
- Testing
- LipiView, Omnicad, Bruder Ocular Surface Analyzer
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Indiana University
Alcohol Use Disorder
Guanfacine for Alcohol Use Disorder (AUD)
The investigators assess whether guanfacine extended release (GXR; 3mg/d) compared with placebo (PBO) will attenuate drinking and drinking-related factors in N=200 men and women with Alcohol Use Disorder (AUD) across 12-weeks.
- Trial name
- NCT06629259
- Testing
- Guanfacine Extended Release (XR)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Autoimmune Hepatitis
Mediterranean Diet Versus Western Diet on Fatigue in Autoimmune Hepatitis Patients
This is a single-center, proof-of-concept pilot study which uses a cross-over design to compare two dietary interventions/treatments: Western Diet (WD) vs Mediterranean (MD) and impact on quality-of-life parameters in AIH.
- Trial name
- NCT06250309
- Testing
- Dietary assignment
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Indiana University
Dental Caries in Children, Tooth Erosion
3D Scanning as an Advanced Tool for Identifying Tooth Lesions in Children
This study focuses on assessing dental caries, erosive tooth wear, and fluorosis in primary teeth using a 3D intraoral digital scanner.
- Conditions
- Dental Caries in Children, Tooth Erosion, Fluorosis, Dental, Dental Caries
- Trial name
- NCT06829550
- Testing
- indirect- 3D digital scanning
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Indiana University
Mild Cognitive Impairment, Dementia
Multi-modal Large Language Model-Empowered Talk Therapy for Older Adults With ADRD
The purpose of this study is to test the usefulness and the effect of Smart Virtual Reminiscence (SVR) therapy intervention on the Behavioral and Psychological Symptoms of Dementia (BPSD) of patients with Alzheimer's Disease and…
- Conditions
- Mild Cognitive Impairment, Dementia, BPSD, BPSD (Behavioral and Psychological Symptoms of Dementia)
- Trial name
- SVR (NCT07499570)
- Testing
- Smart Virtual Reminiscence Therapy, Music Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Alzheimer Disease, Early Onset
Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study
The purpose of this study is to generate preliminary data on the benefit of computerized cognitive training and Tai Chi- Qi Gong training in participants with Early-Onset Alzheimer's Disease.
- Trial name
- LITES (NCT05573490)
- Testing
- Cognitive Training, Tai Chi- Qi Gong, Brain Games
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Dentin Hypersensitivity, Erosive Tooth Wear
Multi-site Study to Look at Tooth Wear and Tooth Sensitivity and the Risk Factors Associated.
The goal of this observational study is to learn about tooth wear and tooth sensistivity and reasons for these conditions in five locations throughout the United States.
- Trial name
- NCT07195357
- Testing
- epidemiological
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Indiana University
Basic Science
Neural Basis of Sensory Learning: Brain Regions
The purpose of this study is to understand how the sensory and motor areas of the brain work together to keep a person's hand movements accurate (sensorimotor learning).
- Trial name
- NCT05079516
- Testing
- Theta burst transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Use Disorder
Enhancing Prospective Thinking in Early Recovery (HOME)
The goal of this clinical trial is to use a novel virtual reality intervention to test for efficacy in reducing alcohol use and increasing abstinence, with concomitant increases in future self-identification, future time…
- Trial name
- HOME (NCT06302413)
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Indiana University
Repetitive Head Impacts
RHI Interval Effects on Brain Health
Military service members frequently experience repetitive insults or impacts to the head (RHIs). The purpose of the proposed randomized controlled trial is to understand how time intervals affect neurological responses to…
- Trial name
- NCT07010887
- Testing
- Short Interval, Long Interval, BrainScope qEEG
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Indiana University
Parkinson Disease, Gait Disorder, Sensorimotor
Robotic Gait Rehabilitation in Parkinson's Disease
The purpose of this study is to investigate the implementation of a novel gait rehabilitation stimulus (G-EO System) that could advance current clinical practices.
- Trial name
- NCT05218187
- Testing
- G-EO End-Effector Gait Trainer, Conventional Physical Therapy Treatment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Muscle Weakness, Muscle; Fatigue, Heart
The Impact of Beef on Muscle Fatigue in Older Adults
The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults.
- Conditions
- Muscle Weakness, Muscle; Fatigue, Heart, Older Adults
- Trial name
- NCT05860088
- Testing
- Beef Diet, Vegetarian Diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Free Flap Reconstruction
Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction
The main purpose of this study is to determine which type of medication, sufentanil or methadone, is better at controlling pain during and, more importantly, after surgery in patients undergoing a head and neck dissection with…
- Trial name
- NCT06784999
- Testing
- sufentanil, methadone
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Indiana University
Subconcussive Head Impact, Omega-3 Fatty Acids
Omega-3 Fatty Acids and Subconcussive Head Impacts
The purpose of the proposed double-blind, randomized placebo-controlled trial is to understand how supplementation with fish oil [docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)] promote brain health against soccer…
- Trial name
- NCT06736925
- Testing
- Omega-3 Fatty Acids (EPA plus DHA), Organic soybean oil, Soccer Heading Model
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Indiana University
Paranoia, Psychotic Disorders
Racial Disparities in the Expression of Paranoia
Paranoia is a pattern of thinking in which people feel suspicious or believe others may want to harm them. It can occur in many people, not only those with a mental health diagnosis, and it can affect daily life, relationships…
- Trial name
- NCT07460453
- Testing
- Guided Visual Imagery Task
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Indiana University
Lung Cancer, Non Small Cell Lung Cancer
Exercise as Maintenance Therapy in Advanced Lung Cancer
The purpose of this study is to examine how a multimodality (having or using a variety of methods to do something) exercise intervention may improve survival, function, and quality of life in participants with advanced lung…
- Conditions
- Lung Cancer, Non Small Cell Lung Cancer, Metastatic Lung Cancer
- Trial name
- NCT06513663
- Testing
- Exercise Intervention
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Indiana University
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