Clinical trials: sponsored by Indiana University
Work of Breathing
The Role of Breathing Perception in Respiratory Control
Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing…
- Trial name
- NCT07470099
- Testing
- Ambient Noise, Increased Auditory Feedback, Noise Distraction
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Indiana University
Work of Breathing
The Role of Heliox in Respiratory Control
Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing…
- Trial name
- NCT07424014
- Testing
- Heliox inspirate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Indiana University
Transplant
Simultaneous Prospective Kidney Transplant Assessment in Combined Liver Kidney Candidates
The purpose of the study is to determine how much a persons kidney function recovers after receiving a simultaneous liver kidney transplant.
- Trial name
- RECOVERY (NCT05717842)
- Testing
- Nuclear Medicine Scan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Retinal Toxicity
Structure and Function of Retinal Disease
Current clinical cameras do not allow clinicians to see the cells of the retina. This study will evaluate a new electronic camera's ability to observe the human retina in finer detail.
- Trial name
- NCT05643157
- Testing
- Adaptive Optics - Optical Coherence Tomography (AO-OCT) retinal imaging
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
Stroke
Locomotor Recovery and Compensation Post-stroke (LRC)
The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke.
- Trial name
- LRC (NCT05081713)
- Testing
- high-intensity training focused on stepping in variable contexts
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Alzheimer Disease
Nicotinic Acid for the Treatment of Alzheimer's Disease
Increased dietary intake of niacin is correlated with reduced risk of Alzheimer's Disease and age-associated cognitive decline. The goal of this study is to collect data on the penetration of commercially available, FDA approved…
- Trial name
- NCT06582706
- Testing
- Extended Release Niacin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Dental Extraction
Use of Remimazolam and Fentanyl for Procedural Sedation in Patients Undergoing Dental Extraction
The goal of this clinical trial is to learn if a combination of the two established sedation drugs remimazolam and fentanyl, can put the subject to sleep during a scheduled extraction procedure.
- Trial name
- NCT06793358
- Testing
- fentanyl and Remimazolam
- Where
- United States
- Sponsor
- Indiana University
Surgery
ESP Block VS Intrathecal Opioid After Laparoscopic Colorectal Surgery
This study is being done to compare 2 types of pain control methods and determine which is more effective postoperatively for laparoscopic colorectal surgery.
- Trial name
- NCT05257941
- Testing
- IT Injection, ESP Block
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Indiana University
Asthma
Efficacy and Safety of Slow Release Dehydroepiandrosterone (DHEA )
There is evidence to suggest that DHEA-based treatment could be beneficial to patients with asthma, yet one of the main treatments for asthma (taking glucocorticoids, a hormone that is effective in reducing inflammation)…
- Trial name
- NCT07179952
- Testing
- Slow Release DHEA
- Volunteers
- 30 people
- Sponsor
- Indiana University
Colonoscopy, Positive-Pressure Respiration
Comparison of High-flow Oxygen With or Without Nasal Positive Airway Pressure (PAP) During Propofol Sedation for Colonoscopy in an Ambulatory Surgical Center
The primary objective of the prospective study is to compare the incidence, duration, and severity of oxygen desaturation in high-risk patients randomized to nasal mask with nasal positive airway pressure (PAP) or standard care…
- Trial name
- NCT05754255
- Testing
- Nasal Cannula, Nasal Positive Airway Pressure System
- Where
- United States
- Sponsor
- Indiana University
Traumatic Brain Injury
Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression
The purpose of this study is to improve behavior control displayed by persons with traumatic brain injury by assessing effectiveness of treatments for post-TBI irritability and aggression.
- Trial name
- NCT01821690
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Indiana University
Mitochondrial Energetics, Dietary Nitrate
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men
Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition…
- Conditions
- Mitochondrial Energetics, Dietary Nitrate, Disuse Atrophy (Muscle) of Lower Leg
- Trial name
- NCT07161973
- Testing
- Beetroot Juice - Active
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Premature Lungs
Physiological Phenotyping of Respiratory Outcomes in Infants Born Premature
The purpose of this study is to examine if infants are more likely to suffer from respiratory complications during their first year of life due to being born premature.
- Trial name
- P3 (NCT03906708)
- Testing
- Diffusion Capacity of the Lung for Carbon Monoxide (DLCO)
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- Indiana University
Gastroparesis
Gastric Per-Oral Endoscopic Myotomy (G-POEM) for the Treatment of Gastroparesis
Gastric Per-Oral Endoscopic Myotomy (G-POEM) is a procedure for the Treatment of Gastroparesis.
- Trial name
- G-POEM (NCT04434781)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pancreatic Neoplasm
Endoscopic Ultrasound Radiofrequency Ablation, Database Repository
The purpose of having this database is to collect data related to endoscopic ultrasound RFA procedures performed by Indiana University EUS physicians for the treatment of tumors or adenopathy.
- Trial name
- EUS-RFA (NCT04693754)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Esophageal Fistula, Esophageal Perforation
Endoscopic Management of Esophageal Wall Defects
The study aim at comparing outcomes from the implementation of various endoscopic closure techniques including stenting and suturing on the healing and resolution of esophageal wall defects.
- Trial name
- NCT04571541
- Testing
- Stenting
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Achalasia
Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository
POEM (Per-Oral endoscopic myotomy (creating a muscle [esophagus] opening), an incision-less (no cutting of the surface of the body) endoscopic procedure, is an effective non-surgical alternative to release the muscle \& sphincter…
- Trial name
- POEM (NCT02770859)
- Testing
- POEM (Per Oral Endoscopic Myotomy)
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Chronic Pancreatitis
Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis (EUS-CPN) for Chronic Pancreatitis
Physicians need a tracking system for specific treatment modalities, and data to determine the impact of endoscopic ultrasound pain management for patients with chronic pancreatitis.
- Trial name
- CPN (NCT04403074)
- Testing
- Celiac Plexus Neurolysis
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Indiana University
Testicular Cancer
Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.
This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular…
- Trial name
- RPLND (NCT06593665)
- Testing
- Inrathecal Morphine, Intravenous Methadone
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Indiana University
Vaccination
Mhealth Supported Bundle to Improve Vaccination Completion
Supported be a digital vaccine registry the investigators will test the impact of automated appointment reminders, real time appointment reminders, motivational interviewing and targeted vaccine on routine childhood vaccine…
- Trial name
- NCT05520736
- Testing
- Appointment reminders, motivational interviewing and targeted vaccine drives
- Where
- Nigeria
- Volunteers
- 2,855 people, healthy volunteers welcome
- Sponsor
- Indiana University
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