Clinical trials: sponsored by Indiana University
Cystic Fibrosis (CF), Chronic Rhinosinusitis (CRS)
Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume…
- Trial name
- NCT06996951
- Testing
- STOP NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID, CONTINUE NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Indiana University
Alzheimer Disease, Dementia
Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support
Nursing home (NH) patients with Alzheimer's disease and related dementias often receive unwanted, burdensome treatments such as hospitalization.
- Trial name
- APPROACHES (NCT03323502)
- Testing
- APPROACHES ACP Specialist Program, Standard of care
- Where
- 2 sites in United States
- Volunteers
- 47,396 people
- Sponsor
- Indiana University
Airway Disease
Determining Airway pH by Compartmental Exhaled Nitric Oxide Levels During Alkaline Buffer Challenge
Airway pH imbalances cause numerous adverse physiological changes within the airways, including hyperreactivity, cough, bronchoconstriction, ciliopathy, decreased response to bronchodilators, bacterial growth…
- Trial name
- NCT04738422
- Testing
- Alkaline glycine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Indiana University
Upper Limb Rehabilitation, Stroke
Activities of Daily Living (ADL) Virtual Reality (VR) for Acquired Brain Injury (ABI) Upper-Limb Rehabilitation
Acquired brain injury (ABI) individuals have shown greater engagement and functional recovery when trained in virtual reality (VR)-assisted rehabilitation therapies.
- Trial name
- NCT07026630
- Testing
- Cooking In the Kitchen
- Where
- United States
- Sponsor
- Indiana University
Type 2 Diabetes, Prediabetes
A Mindfulness-based Intervention for Adolescents With Prediabetes or Type 2 Diabetes
The purpose of this study is to conduct a mindfulness-based intervention for adolescents referred for prediabetes or type 2 diabetes treatment to 1) evaluate feasibility and acceptability of the intervention for future research…
- Trial name
- L2BT2D (NCT07270900)
- Testing
- Mindfulness Based Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Basic Science
Frontal and Parietal Contributions to Proprioception and Motor Skill Learning
The purpose of this study is to understand how the different regions of the brain affect our sense of limbs in space (proprioception) and in turn our hand movements (motor skill learning).
- Trial name
- NCT05739994
- Testing
- Theta burst transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Indiana University
Nasal Valve Collapse, Nose Enhancement
Cartilage Remodeling Using Low-Temperature Radiofrequency for Nasal Airway Reconstruction
The goal of this study is to evaluate the efficacy of using the Vivaer low-temperature radio-frequency (LTRF) device to reshape ex-vivo human nasal or auricular cartilage for use in cosmetic and functional septorhinoplasty.
- Trial name
- NCT07032675
- Testing
- Low-temperature radio-frequency reshaping of autologous cartilage nasal and/or auricular cartilage
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Anxiety, Depression
POST Facilitation for Community Dwelling Older Adults (POST-RCT)
We propose to study the effects of Physician Orders for Scope of Treatment (POST) Facilitation in a randomized controlled trial in a population of community dwelling older adults who qualify for POLST facilitation, including…
- Conditions
- Anxiety, Depression, Post Traumatic Stress Disorder, Satisfaction
- Trial name
- POST-RCT (NCT04070183)
- Testing
- POST Facilitation, Home Safety Evaluation
- Where
- 3 sites in United States
- Volunteers
- 389 people
- Sponsor
- Indiana University
Pressure Ulcer, Ankle, Prosthesis User
Limb Health and Socket Pressure in Response to Powered Ankle Protheses
this project seeks to understand and quantify the effects of powered transtibial prostheses on socket loading and direct measures of residual limb health so as to inform the optimization of prosthesis fit.
- Conditions
- Pressure Ulcer, Ankle, Prosthesis User, Prosthesis Durability, Mobility Limitation
- Trial name
- OPORP (NCT05112679)
- Testing
- PROPRIO FOOT® by Ossur & Empower ankle by Ottobock
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Indiana University
Caregiver Burden, Alzheimer Disease
I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms
This study is a randomized, controlled trial (RCT) to evaluate the effect of Brain CareNotes (a mobile health application) on the burden experienced by unpaid caregivers of patients with dementia and on the behavioral and…
- Trial name
- I-CARE 2 (NCT05733520)
- Testing
- Brain CareNotes, Dementia Guide Expert
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- Indiana University
Eosinophilic Esophagitis
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study
This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus.
- Trial name
- EOE (NCT03312686)
- Testing
- endoflip
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Informed Consent, HIV Infections
Community Solutions to Adolescent Research Consent - Minor Consent for Biomedical HIV Research
Public deliberation is a novel method for engaging the public in collective decision-making. Its goal is to facilitate debate and discussion that: 1) fosters the formation of reasonable and informed opinions, 2) permits…
- Trial name
- C-START (NCT05371327)
- Testing
- Public deliberation
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Indiana University
Germ Cell Tumor
Maintenance Zanzalintinib With Etoposide After HDCT in GCT
This is an open label, single arm phase I/II trial of maintenance zanzalintinib in combination with oral etoposide in patients with relapsed GCT treated with HDCT and PBSCT with a safety lead-in cohort in patients with relapsed…
- Trial name
- NCT06937866
- Testing
- Zanzalintinib, Etoposide Capsule
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Indiana University
Autism
Maternal Biomarkers and Environmental Contributors to Autism Spectrum Disorders in Children of First-time Mothers
This study will recruit nuMoM2b participants to complete autism screening surveys and will identify 200 children with autism and 400 controls for the study.
- Trial name
- NCT07070804
- Volunteers
- 600 people
- Sponsor
- Indiana University
Low Vision
Obstacle Negotiation in Older People With and Without Vision Impairment
Falls are common among people with vision impairment and can lead to devastating health consequences. Understanding the functions of vision and how the visual characteristics of obstacles in the walking path impact the gait of…
- Trial name
- NCT05888441
- Testing
- Obstacle characteristics
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
Stroke, Acute Ischemic
Macrowire for IntracraNial Thrombectomy
The aim of this study is to develop a multicenter database of patient data and outcomes for patients undergoing intracranial thrombectomy for acute ischemic stroke secondary to emergent large vessel occlusion with delivery of…
- Trial name
- MINT (NCT06148675)
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Indiana University
Pancreatic Neoplasms
Respiratory-gated Stereotactic Body Radiation Therapy for Adenocarcinoma of the Pancreas or Periampullary Region
This is a single center, single arm unblinded prospective study of the safety of pancreatic stereotactic body radiation therapy (SBRT) in patients with unresectable, borderline resectable, or recurrent pancreatic/periampullary…
- Trial name
- NCT02780648
- Testing
- Stereotactic Body Radiation
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Amputation, Prosthesis User
Digital Weight Bearing Shape Capture Socket Technology
The study will determine if Symphonie Aqua Digital System, a new method of socket creation, in a weight-bearing environment, may produce more successful fitting and comfortability \& functional outcomes than traditional sockets…
- Conditions
- Amputation, Prosthesis User, Residual Limbs
- Trial name
- DWB (NCT05749952)
- Testing
- Symphonie Aqua Digital System mediated sh
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
COVID-19, Sleep
COVID-19 Health Adjustments in Nutrition, General Wellness, and Exercise
The purpose of this study is to find out whether the COVID pandemic has affected participants' current physical activity, fitness, blood pressure, sleep, and mental stress to better understand its long-term health effects.
- Conditions
- COVID-19, Sleep, Immunization; Infection, Physical Inactivity
- Trial name
- CHANGE (NCT07128095)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Indiana University
T Cell Response to Dried Plum, Vitamin D Influence on Immune Response
Prebiotics (Dried Plum) and Immune Function in Postmenopausal Women
Prior studies have shown that dietary supplementation with dried plums (also known as prunes) reduces bone loss in postmenopausal women.
- Conditions
- T Cell Response to Dried Plum, Vitamin D Influence on Immune Response, Dried Plum and Immune Function
- Trial name
- NCT07222111
- Testing
- Dried plums
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
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