Clinical trials: sponsored by Indiana University
Alcoholic Hepatitis
Trial of Anakinra (Plus Zinc) or Prednisone in Patients With Severe Alcoholic Hepatitis
This multicenter, randomized, double blinded, placebo-controlled clinical trial is focused on novel treatments for severe alcoholic hepatitis (AH), a life-threatening stage of alcoholic liver injury that has a short-term…
- Trial name
- AlcHepNet (NCT04072822)
- Testing
- Anakinra and Zinc, Prednisone
- Where
- 10 sites in United States
- Volunteers
- 147 people
- Sponsor
- Indiana University
Cystectomy
Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy
The purpose of this study is to compare the difference between four different pain control methods in patients who will be having a cystectomy surgery (surgical removal of the bladder).
- Trial name
- NCT04300231
- Testing
- epidural bupivacaine 0.05%, Liposomal bupivacaine, bupivacaine 0.125%
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Indiana University
Colorectal Cancer Screening
Facilitators and Barriers to Cancer Screening: Stakeholder Perspectives on Implementation
The rate of screening for colorectal cancer (CRC) in the U.S. remains low (under 65%), meaning that thousands of people die of colorectal cancer unnecessarily.
- Trial name
- NCT04683744
- Testing
- Semi-structured interviews-Patients, Semi-structured interviews-Health system
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Indiana University
Vulvar Cancer, Ovarian Cancer
Study of a Rapid Triadic Communication Intention Elicitation Intervention to Improve Supportive Oncology Care Delivery
The purpose of this study is to help test an idea designed to foster more supportive talk between providers (doctors or nurse practitioners), patients, and caregivers during an outpatient oncology appointment.
- Conditions
- Vulvar Cancer, Ovarian Cancer, Uterine Cancer, Vaginal Cancer
- Trial name
- PRECursOr (NCT05995860)
- Testing
- Intervention group triads
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Indiana University
Alcohol Use Disorder
Frontal-Striatal Reward Circuit Neuromodulation and Alcohol Self-Administration
This will be a single site randomized, 2-session, within-subject cross-over design pilot study. 20 enrolled (of 30 consented) subjects reporting varying levels of binge and high intensity drinking, defined as at least 2 episodes…
- Trial name
- NCT04971681
- Testing
- Low frequency repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Indiana University
HIV Pre-exposure Prophylaxis, Stigma, Social
Adapting an Adolescent Friendly PrEP Program for Uasin Gishu County-Kenya
The purpose of this study is to examine the implementation ( e.g. training, reach, acceptability) of a a youth friendly pre-exposure prophylaxis (PrEP) peer mentorship program for Adolescents and Young Adults (AYA).
- Trial name
- NCT05545449
- Testing
- PrEP Peer Mentor Program
- Where
- Kenya
- Volunteers
- 5 people
- Sponsor
- Indiana University
Monoclonal Gammopathy of Undetermined Significance
Observation of the Incidence and Natural History of MGUS in Patients Undergoing Weight Reduction Surgery
Screening study to determine incidence of MGUS in this patient population
- Trial name
- NCT03855878
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Indiana University
Contraception
Integration of Family Planning Services Into Anticoagulation Monitoring Services
Currently there are approximately 400 women of reproductive age enrolled in outpatient monitoring of warfarin therapy through AMS.
- Trial name
- NCT02773810
- Testing
- Integrated Family Planning Services
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Indiana University
Prenatal Care Late, Contraceptive Usage
Community-based Provision of Urine Pregnancy Tests as Linkage to Reproductive Health Services
Kenyan families experience persistently high rates of maternal and neonatal mortality, which disproportionately affects women with low income and education and those who live far from health services.
- Conditions
- Prenatal Care Late, Contraceptive Usage, Pregnancy Complication
- Trial name
- NCT03626597
- Testing
- Urine Pregnancy Test, CHV-based post-test counseling & referral, Phone-based post-test counseling & referral
- Where
- Kenya
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cancer Screening Tests
Helping Patients and Providers Make Better Decisions About Colorectal Cancer Screening
Precision prevention holds great promise for colorectal cancer (CRC) screening but has not been adequately explored. A patient's chance of having an advanced colorectal neoplasm (ACN), i.e.
- Trial name
- NCT04683731
- Testing
- Decision aid without personalized message, Decision aid with personalized message, Provider notification without personalized message
- Where
- 2 sites in United States
- Volunteers
- 1,111 people
- Sponsor
- Indiana University
Scar, Skin Scarring
Scar Appearance After Postoperative Hydrocolloid Dressing Versus Standard Petrolatum Ointment
Patients will be randomized either to receive standard daily dressing or hydrocolloid dressing using a randomization generator. After closing the wound with the sutures,the scar will be covered by a hydrocolloid dressing, which…
- Conditions
- Scar, Skin Scarring, Skin Cancer, Wound Heal
- Trial name
- NCT05618912
- Testing
- Hydrocolloid dressing, Petrolatum jelly dressing
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Indiana University
Heart Failure
Biventricular Versus Right Ventricular Pacing
The study is a randomized, single-blind crossover prospective study in which investigators will determine the clinical outcomes of cardiac resynchronization therapy (CRT) pacing modalities in patients with left ventricular assist…
- Trial name
- NCT06298669
- Testing
- Biventricular Pacing, Right Ventricular Pacing
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Indiana University
Breast Neoplasm, Breast Cancer
Facilitating Adaptive Coping With Fear of Recurrence Among Breast Cancer Survivors
Fear of cancer recurrence (FCR) is a highly prevalent, disruptive, and under-treated problem for breast cancer survivors. This randomized controlled trial will test the efficacy of group-based Acceptance and Commitment Therapy…
- Conditions
- Breast Neoplasm, Breast Cancer, Breast Carcinoma, Malignant Neoplasm of Breast
- Trial name
- NCT05364450
- Testing
- Enhanced Usual Care, Acceptance Commitment Therapy, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- Indiana University
Postnatal Growth Disorder
Physiologic Approach to Sodium Supplementation in Premature Infants
Postnatal growth failure occurs in up to 50% of very low birth weight (VLBW, <1500 grams at birth) infants as assessed by discharge weight.
- Trial name
- Salt to Grow (NCT03889197)
- Testing
- Sodium supplementation guided by urine sodium concentration algorithm
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Acute Heart Failure
Short Stay Unit vs Hospitalization in Acute Heart Failure
The majority of the over one million annual AHF hospitalizations originate from the emergency department. Admitting and re-admitting lower risk AHF patients who don't need prolonged hospitalization may increase their risk for…
- Trial name
- SSU-AHF (NCT03302910)
- Testing
- Short Stay Unit, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 194 people
- Sponsor
- Indiana University
Colorectal Neoplasms
Chromoendoscopy or Narrow Band Imaging (NBI) for Improving Adenoma Detection in Colonoscopy
Narrow band imaging or electronic chromoendoscopy might provide similar adenoma detection capabilities while limiting time spent when compared to conventional chromoendoscopy method.
- Trial name
- NCT04192929
- Testing
- Narrow band imaging, Chromoendoscopy, High definition white light endoscopy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Prostate Cancer, Urinary Incontinence
Physical Therapy for Men Undergoing Prostatectomy
The purpose of this study is to determine if pelvic floor muscle training with a physical therapist before and after surgery will improve health-related quality of life following robot-assisted radical prostatectomy.
- Conditions
- Prostate Cancer, Urinary Incontinence, Pelvic Floor Physical Therapy
- Trial name
- NCT02558946
- Testing
- Pelvic Floor Muscle Physical Therapy, Control Group
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Indiana University
Autism
Validation of Indiana's Early Evaluation Hub System
The investigators' objective is to test an innovative method of autism diagnosis that integrates clinical evaluation and assessment of biobehavioral markers in a large high-risk community-referral sample of children in the…
- Trial name
- EAER21 (NCT06586788)
- Testing
- Eyelink Portable Duo, Integrated PCP Diagnosis and Eye-tracking Biomarker
- Where
- 7 sites in United States
- Volunteers
- 154 people
- Sponsor
- Indiana University
Postoperative Pain
Effect of Perioperative Gabapentin on Postoperative Opioid Requirements
The purpose of this study is to determine if preoperative gabapentin is noninferior to preoperative and postoperative gabapentin for pain control in patients undergoing surgery for pelvic organ prolapse.
- Trial name
- NCT05494385
- Testing
- Preoperative Gabapentin/Postoperative Gabapentin
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Indiana University
Stroke, Gait Disorders, Neurologic
High Vs Low Intensity Virtual Reality Gait Training in Individuals with Chronic Stroke
The purpose of this pilot study is to investigate the feasibility of 1) providing virtual reality walking training using a custom developed setup able to be replicated in routine clinical practice and 2) combining the virtual…
- Trial name
- NCT06522477
- Testing
- Virtual reality gait training
- Where
- United States
- Sponsor
- Indiana University
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