Clinical trials: sponsored by Indiana University
Brain Injuries
Intermittent Hypoxia Paired with High Intensity Training in Brain Injury
The central hypotheses are that HIT combined with AIH results in: 1) greater locomotor gains as compared to HIT alone; 2) improvements in gait quality and motor coordination during walking, and 3) changes in measures of community…
- Trial name
- NCT04472442
- Testing
- Intermittent hypoxia
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Indiana University
Preterm Premature Ruptured Membranes
Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes
Preterm Premature Rupture of Membranes (PPROM) is treated with an antibiotic, erythromycin or azithromycin, to prolong pregnancy.
- Trial name
- PEACE (NCT01556334)
- Testing
- Azithromycin, Erythromycin
- Where
- United States
- Sponsor
- Indiana University
Renal Malignant Tumor
Correlation of Renal Mass Pathologic Grade and Contrast Enhanced Ultrasound (CEUS)
Patients with renal lesions suspicious for renal cell carcinoma (RCC) have a variety of different treatment pathways available to them.
- Trial name
- NCT03821376
- Testing
- Contrast enhanced ultrasound with Lumason
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Metastatic Breast Cancer
Telephone Support for Metastatic Breast Cancer Patients
This trial tests telephone-based Acceptance and Commitment Therapy (ACT), a type of psychotherapy, to reduce fatigue interference with activities, mood, and cognition in metastatic breast cancer (MBC) cancer patients.
- Trial name
- NCT03998618
- Testing
- Acceptance and Commitment Therapy, Education/Support
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- Indiana University
Mental Health Wellness 1, Happiness
Effects of an 8-day Advanced Meditation, Samyama on Physical, Psychological and Spiritual Wellbeing ,and Associated Neural Mechanisms
The purpose of this study is to investigate the effects of Samyama program on blood levels of selected neurotransmitters before and after the program, and associate with corresponding effects on mind/psyche before and after the…
- Conditions
- Mental Health Wellness 1, Happiness, Depression, Consciousness, Level Altered
- Trial name
- NCT04366544
- Testing
- Part A1: Survey, Part A2: Sample collection, Part B:
- Where
- United States
- Volunteers
- 759 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hepatic Disease
Evaluation of the Efficacy of Contrast Enhanced Ultrasound Compared to MRI for Differentiation of Hepatic Lesions
In patients with hepatic lesions, to evaluate the efficacy of contrast enhanced ultrasound compared to MRI in differentiating focal nodular hyperplasia and hepatic adenoma.
- Trial name
- NCT03652636
- Testing
- Sulfur Hexafluoride Microspheres
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Indiana University
Type 1 Diabetes
Effect of Prebiotics on the Gut Microbiome Profile and Beta Cell Function
Data suggest that intestinal microbiota might be critically involved both in autoimmunity and in glucose homeostasis. An acetylated and butyrylated form of high amylose maize starch (HAMS-AB) that increases beneficial short chain…
- Trial name
- NCT04114357
- Testing
- Acetylated and Butyrylated High Amylose Maize Starch
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Healthy
Healthy Volunteer Short Chain Fatty Acid Study
The purpose of this study is to evaluate the production of short chain fatty acids (fatty acids are part of your diet) in stool through the measurement of fecal inulin after a one-time ingestion of 10-gram dose of inulin among…
- Trial name
- NCT05254340
- Testing
- Inulin
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dementia, Alzheimer Type
Technology Intervention to Support Caregiving for Alzheimer's Disease (I-CARE)
The specific aims of this study are 1) to test the trial and intervention feasibility of Brain Care Notes (BCN) app, 2) To estimate the effect size of BCN on reducing informal caregiver burden at 6 months, and 3) To estimate the…
- Trial name
- I-CARE (NCT03119259)
- Testing
- ABC Clinical Program, BCN
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Indiana University
Dental Anxiety
Comparing Brief Relaxation Period to Virtual Reality Period in Reducing Dental Anxiety Prior to Root Canal Treatment
The goal of this study is to evaluate non-drug approaches to reducing dental anxiety prior to non-surgical root canal treatment.
- Trial name
- NCT05720897
- Testing
- Auditory Alone, Relaxation Virtual Reality
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
NSCLC, Stage III
Using Circulating Tumor DNA to Personalize Duration of Consolidation Durvalumab
This research aims to incorporate ctDNA analysis into clinical practice to individualize therapy in patients with stage III NSCLC by moving to a treatment-by-marker based approach (as opposed to treatment based on clinical or…
- Trial name
- NCT05757843
- Testing
- Signatera ctDNA test, Durvalumab
- Sponsor
- Indiana University
Hypertrophic Skin Condition of Anterior Abdomen
Negative Pressure Wound Therapy-PICO: Cosmesis in Repeat C-Sections
There are millions of births each year with 32% of women undergoing cesarean sections (C-sections), which results in skin scarring. Repeat C-sections increased by 178% from 1979-2010.
- Trial name
- NCT05266053
- Testing
- PICO 7 dressing, Standard wound dressing
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cardiovascular Diseases, Sedentary Behavior
Hoosier Sport: Developing and Implementing a Sustainable Campus-Community Partnership in Rural Indiana
The clinical trial aims to develop and pilot test a multilevel physical activity (PA) intervention called the Hoosier Sport program.
- Trial name
- NCT06280859
- Testing
- Hoosier Sport
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dementia
Indiana Palliative Excellence in Alzheimer's Care Efforts
The overarching goal of this research is to improve the care of community dwelling patients with dementia and their family caregivers through an innovative model of supportive care that combines an existing, evidence-based…
- Trial name
- IN-PEACE (NCT03773757)
- Testing
- IN-PEACE Dementia Care Coordination
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- Indiana University
Myalgia
The Effect of Pretreatment With Roc on Succinylcholine Myalgias
Succinylcholine is a medication (depolarizing muscle relaxant) that is used as part of an anesthetic (going to sleep for surgery). This medication can cause significant muscle soreness.
- Trial name
- NCT04581395
- Testing
- non-pretreated Succinylcholine, succinylcholine 1 minute after rocuronium pretreatment, succinylcholine 2 minutes following rocuronium pretreatment
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Heart Failure, Heart Failure Acute
Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial
Nearly 80% of acute heart failure (AHF) patients admitted to the hospital are initially treated in the emergency department (ED). Once admitted, within 30 days post-discharge, 27% of patients are re-hospitalized or die.
- Conditions
- Heart Failure, Heart Failure Acute, Acute Cardiac Failure, Acute Cardiac Pulmonary Edema
- Trial name
- N-FURIOUS (NCT03259165)
- Testing
- Nitrates, Loop Diuretics
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Indiana University
Sensory Disorders, Sensory Processing Disorder
Online Parent-Report Evaluation of the Effects of Processed Music
The study aims to examine effectiveness of the Safe and Sound Protocol (SSP) on sensory, digestive, and eating behaviors in children currently receiving therapy.
- Conditions
- Sensory Disorders, Sensory Processing Disorder, Autism Spectrum Disorder, Eating Disorders
- Trial name
- NCT05249270
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Indiana University
Pediatric Cancer
Cope 360 App for Caregivers of Children With Cancer
To date, most caregiver focused interventions have been targeted at caregivers of adults with cancer, completely ignoring the unique needs of caregivers of children with cancer.
- Trial name
- NCT05112458
- Testing
- Cope 360 mobile health application, Usual care
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Peripheral Arterial Disease
Intermittent Pneumatic Compression to Improve Revascularization Outcome
The purpose of this study is to investigate whether daily treatment with intermittent pneumatic leg compressions (IPC) following a nonsurgical vascular procedure improves circulation and enhances walking distance.
- Trial name
- NCT04250675
- Testing
- Intermittent pneumatic leg compressions
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Indiana University
Generalized Anxiety Disorder, Chest Pain
Patient-centered Treatment of Anxiety After Low-Risk Chest Pain in the Emergency Room
The goal of this research is to compare the benefits and risks of three anxiety treatments that are pragmatic, graduated in the level of resource intensity, and have demonstrated efficacy and feasibility for real world adoption.
- Conditions
- Generalized Anxiety Disorder, Chest Pain, Panic
- Trial name
- PACER (NCT04811521)
- Testing
- Primary care follow-up, Online Self-Administered Anxiety Management Program plus Peer Support Guidance, Therapist-Administered Cognitive Behavioral Therapy
- Where
- 5 sites in United States
- Volunteers
- 375 people
- Sponsor
- Indiana University
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