Clinical trials: sponsored by Indiana University
Hepatocellular Carcinoma (HCC)
Y90 Radiation Segmentectomy vs SBRT for HCC
The proposed study is a single site, prospective, randomized pilot study to assess the feasibility of recruitment of patients into a trial evaluating the efficacy and tolerability of selective transarterial Y90 radioembolization…
- Trial name
- SBRT vs Y90 (NCT04235660)
- Testing
- Yttrium-90 Radiation Segmentectomy, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Indiana University
Cardiac Event, Emotions
Emotion Regulation Intervention to Sustain Physical Activity in Rural-dwelling Women and Men After Myocardial Infarction
The purpose of this study is to evaluate early preliminary efficacy of the eMotion intervention in US adults who have experienced a first cardiac event and participating in phase II cardiac rehabilitation.
- Trial name
- eMotion (NCT04441086)
- Testing
- eMotion, Healthy Living Active Control
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Diabetic Foot, Ulcer Foot
Diabetic Foot Ulcer Recurrence: Pilot Study
In this prospective pilot study, patients with DFU visiting the Indiana University Comprehensive Wound Center will be enrolled. Patients enrolled in the study will be followed for 16 weeks for wound closure(Phase A), and will…
- Trial name
- DFUCO (NCT03479242)
- Testing
- no interventions
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Burns Multiple, Burns
AutoMated BUrn Diagnostic System for Healthcare (AMBUSH)
The primary objective of this study is to develop a high accuracy and automated system that can provide early assessment of burn injuries with at least 90% accuracy in absence of burn experts, using AI and FDA cleared harmonic…
- Conditions
- Burns Multiple, Burns, Thermal Burn, Burn Infection
- Trial name
- AMBUSH (NCT05167461)
- Testing
- Collection of imaging by ultrasonography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Depression, Major Depressive Disorder
eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients
The objective of this randomized controlled trial is to evaluate whether the investigators modernized IMPACT intervention for depression (eIMPACT), delivered before the onset of cardiovascular disease (CVD), reduces the risk of…
- Conditions
- Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms
- Trial name
- NCT02458690
- Testing
- Beating the Blues (BtB), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Indiana University
Subjective Cognitive Decline
DEMA-Pro Intervention for Seniors With Subjective Cognitive Decline and Living at Home
More than 4.4 million patients receive home health services following discharge from the hospital or rehabilitation facility. A substantial number (70%) are older adults with subjective cognitive decline (SCD), an early clinical…
- Trial name
- NCT04796415
- Testing
- the DEMA-Pro intervention
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Indiana University
Estrogen Receptor-negative Breast Cancer, Progesterone Receptor-negative Breast Cancer
Medroxyprogesterone +/- Cyclophosphamide & Methotrexate in Hormone Receptor-Negative Recurrent/Metastatic Breast Cancer
The purpose of this study is to evaluate the impact of MPA alone and in combination with low dose oral chemotherapy in patients with ER- and PR- advanced breast cancer.
- Conditions
- Estrogen Receptor-negative Breast Cancer, Progesterone Receptor-negative Breast Cancer, Recurrent Breast Cancer, Stage IV Breast Cancer
- Trial name
- NCT00577122
- Testing
- Medroxyprogesterone progesterone acetate (MPA), Medroxyprogesterone with Cyclophosphamide + Methotrexate
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Leukemia, Myelomonocytic, Acute
Pilot Study of Erlotinib for the Treatment of Patients With de Novo Acute Myeloid Leukemia
This research study is looking for patients with newly diagnosed acute myeloid leukemia (AML), AML that has returned (relapsed), or it has not responded adequately to previous treatments.
- Trial name
- NCT01174043
- Testing
- Erlotinib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Indiana University
Adverse Drug Events
Improving Safety by Basic Computerizing Outpatient Prescribing
The study will measure the effect of basic clinical decision support on medical errors and adverse drug events in the ambulatory setting.
- Trial name
- NCT01091038
- Testing
- Basic Clinical Decision Support, Routine Care
- Where
- 2 sites in United States
- Volunteers
- 228 people
- Sponsor
- Indiana University
Substance Use Disorders, Overdose
Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention
The investigators seek to assess the effectiveness of Project POINT (Planned Outreach, Intervention, Naloxone, and Treatment). As originated in Indianapolis, Project POINT is a collaboration between Indianapolis Emergency Medical…
- Trial name
- POINT (NCT03336268)
- Testing
- POINT
- Where
- 2 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Indiana University
Wound Heal
Electroceutical Dressing Technology (EDT) Against Wound Microbial Biofilm Infection
There are currently limited treatments available that show anti-biofilm efficacy for wound infection management Biofilms account for over 80% of infections and approximately 65% of nosocomial infections caused by microorganisms…
- Trial name
- EDT BioFilm (NCT04794621)
- Testing
- Electroceutical Dressing Technology-EDThi, Adding EDTlo (Procellera®) for 3 weeks after use of EDThi
- Where
- 3 sites in United States
- Volunteers
- 112 people
- Sponsor
- Indiana University
Sports Injury, Intermittent Fasting
The Effect of Intermittent Fasting on Acute Subconcussive Head Impacts
The purpose of this study is to examine the effect of intermittent fasting on the acute neural responses to subconcussive head impacts.
- Trial name
- NCT05236127
- Testing
- Soccer Heading, Intermittent Fasting
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Conscious Sedation
Gabapentin to Improve Patient Tolerance in Endoscopic Retrograde Cholangiopancreatography (ERCP)
The standard approach to sedation in endoscopic retrograde cholangiopancreatography (ERCP) involves the use of benzodiazepines and opiates to achieve a moderate depth of sedation.
- Trial name
- NCT01143766
- Testing
- Gabapentin, Standard sedation regimen
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Indiana University
Chronic Leg Ulcer, Kaposi Sarcoma
Compression Therapy for Leg Ulcers and Kaposi Sarcoma in Western Kenya
The efficacy of locally sourced compression therapy in the management of chronic leg ulcers and Kaposi Sarcoma in western Kenya will be studied in a rural setting
- Conditions
- Chronic Leg Ulcer, Kaposi Sarcoma, HIV/AIDS and Infections
- Trial name
- NCT03404297
- Testing
- Locally sourced compression therapy
- Where
- 2 sites in Kenya
- Volunteers
- 30 people
- Sponsor
- Indiana University
Brain Tumors, Quality of Life
Bridging the Gap: Using Video Art to Document the Human Face of Disease & Predict Quality of Life Assessments in Brain Tumor Patients
The goal of this study is to explore whether facial expression changes in visual portraits correlate with Quality of Life (QOL) questionnaire responses before and after pet therapy sessions and to compare scores of QOL…
- Conditions
- Brain Tumors, Quality of Life, Animal Assisted Therapy
- Trial name
- NCT02890940
- Testing
- Pet Therapy
- Volunteers
- 13 people
- Sponsor
- Indiana University
Cholangiopancreatography, Endoscopic Retrograde
Intraductal Secretin Stimulation Test: What Is the Proper Collection Time?
The aim is to evaluate the peak secretory flow rates and bicarbonate concentrations as determined by a 30 minute intraductal secretin stimulation test in patients with a low likelihood of pancreatic pathology and to compare these…
- Trial name
- IDST (NCT03263481)
- Testing
- Intraductal secretin test (IDST)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Indiana University
Portal Hypertension, Chronic Advanced Liver Disease
Velacur by Sonic Incytes for Portal Hypertension
This is a cross sectional study that evaluates the relationship between LSM (liver stiffness measurement) by Liver Incytes in patients with cACLD (compensated advanced chronic liver disease) and manifestations of portal…
- Trial name
- NCT04576897
- Testing
- Velacur
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Indiana University
Alzheimer Disease, Mild Memory Disturbance
The MObile AssessMENT of Behavioral and Psychological Symptoms of Dementia in Amnestic MCI and AD (MOMENT) Study
The purpose of this research study is to learn whether it is possible and useful for caregivers to report behavioral or psychological symptoms of people with mild memory problems or Alzheimer's disease through a smartphone mobile…
- Conditions
- Alzheimer Disease, Mild Memory Disturbance, Mild Cognitive Impairment
- Trial name
- MOMENT (NCT04482036)
- Testing
- Mobile Phone Application Assessments, Standard Assessments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Indiana University
Free Tissue Flaps
Radial Forearm Versus the Ulnar Forearm Free Flap
This study evaluates donor site outcomes in patients receiving radial forearm free flap reconstruction versus ulnar forearm free flap reconstruction.
- Trial name
- NCT03579277
- Testing
- Radial Forearm Free Flap, Ulnar Forearm Free Flap
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Indiana University
Pain, Amputation Neuroma
Pain After Proximal Digital Amputation Prevention
Finger amputations are common and may be complicated by debilitating nerve pain. This study seeks to determine if nerve pain after digital amputation can be more effectively prevented with either of two new surgical…
- Conditions
- Pain, Amputation Neuroma, Amputation
- Trial name
- PAPDAP (NCT04378062)
- Testing
- Digital nerve procedure
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Indiana University
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