Clinical trials: sponsored by Indiana University
Polycystic Kidney Diseases
Pioglitazone and Lumbar Bone Marrow Fat in Chronic Kidney Disease
Chronic Kidney Disease (CKD) is associated with bone changes and very high fracture rates. A component of bone is marrow. Bone marrow fat is increased in patients with CKD compared to those in the normal population of the same…
- Trial name
- NCT02739750
- Testing
- No intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Indiana University
Sleep Apnea, Obstructive, Respiration Disorders
Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty
This is a research study of the effect of treating laryngomalacia (floppiness of tissue on top of the voice box that can possibly block breathing) found in association with obstructive sleep apnea (blockage of breathing while…
- Trial name
- NCT00394550
- Testing
- supraglottoplasty with laser
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Legal Rights, Medicolegal Aspects
Computer-Supported Management of Medical-Legal Issues Impacting Child Health
The investigators hypothesize that by adding a patient screening and physician alerting module to a computer-based decision support system, the investigators can improve the detection and management of legal issues that may…
- Trial name
- CHICA-MLP (NCT01800669)
- Testing
- CHICA MLP Module, CHICA without the MLP module
- Where
- United States
- Volunteers
- 582 people
- Sponsor
- Indiana University
Breastfeeding
Lactation Cookie Study
Lactation cookies contain ingredients thought to increase breast milk production. Although these cookies are widely purchased and consumed with the intention to increase breast milk supply, no scientific investigation has…
- Trial name
- NCT04805008
- Testing
- Lactation cookies, Control cookies
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cancer
Mechanisms of Active Music Engagement to Improve Health Outcomes of Children With Cancer and Parents
Music therapy, a frequently used arts-based therapy, has become standard palliative care in many pediatric and adult hospitals; however, few studies have examined the mechanisms by which music therapy interventions work.
- Trial name
- PINPOINT (NCT03085927)
- Testing
- Active Music Engagement, Audio Storybooks
- Where
- 4 sites in United States
- Volunteers
- 137 people
- Sponsor
- Indiana University
Gastroschisis
Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis
Gastroschisis is a congenital defect of the abdominal wall that leads to evisceration of various amounts of the abdominal organs.
- Trial name
- NCT03355326
- Testing
- Glycerin Suppository
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colorectal Cancer
Comparing Interventions to Increase Colorectal Cancer Screening
The purpose of this study is to test different approaches to help people understand the purpose of colorectal cancer (CRC) screening, two screening test options available, and the barriers to screening so they can make informed…
- Trial name
- NCT03200366
- Testing
- Tailored DVD, Patient Navigation
- Where
- 2 sites in United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- Indiana University
Type 1 Diabetes
DFMO in Children With Type 1 Diabetes
This study is a multicenter, double-blind, placebo-controlled, 2:1 randomly assigned, phase 1 clinical trial for individuals with type 1 diabetes.
- Trial name
- NCT02384889
- Testing
- Difluoromethylornithine
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Indiana University
Neurobehavioral Manifestations
Prophylaxis Against Malaria to Enhance Child Development (PROTECT Study)
Each year, ~85.3 million pregnant women are at risk of becoming infected with Plasmodium falciparum(1). Among women in sub-Saharan Africa, most of whom have some degree of clinical immunity to malaria, malaria infection in…
- Trial name
- PROTECT (NCT02557425)
- Testing
- No intervention in PROTECT
- Where
- Uganda
- Volunteers
- 272 people
- Sponsor
- Indiana University
QT Interval Prolongation
Methadone-Induced QT Interval Prolongation in a Narcotic Treatment Center
Torsades de pointes (TdP) is a polymorphic ventricular tachycardia associated with prolongation of the heart rate-corrected QT (QTc) interval on the electrocardiogram (ECG).
- Trial name
- NCT02898337
- Testing
- AliveCor handheld mobile ECG
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Indiana University
Pancreatectomy
Laparoscopic Versus Open Pancreatectomy
The study will randomized patients to either open or laparoscopic pancreatic surgery. The primary purpose of the study is to determine whether laparoscopic distal pancreatectomy is associated with improved outcomes compared to…
- Trial name
- NCT00988793
- Testing
- Laparoscopic distal pancreatectomy, Open distal pancreatectomy
- Where
- United States
- Sponsor
- Indiana University
Opioid Use, Opioid-use Disorder
Effect of Preoperative Counseling on Postoperative Opioid Use Following Knee Arthroscopy.
Our study looks to evaluate the effect of brief preoperative counseling on opioid use following knee arthroscopy. We aim to quantify the effect we have as providers in changing patient behavior postoperatively in terms of the…
- Trial name
- NCT04083209
- Testing
- Opioid counseling
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Indiana University
Surgery
Low Dose IV Dexamethasone in Prolonging Caudal Anesthesia in Children Undergoing Genitourinary Surgery
Caudal injection of local anesthetic is a neuraxial technique routinely performed on young children for postoperative analgesia after lower abdominal and lower extremity surgical procedures.
- Trial name
- NCT02436265
- Testing
- Dexamethasone, Ropivacaine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Indiana University
Pre-Exposure Prophylaxis
Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers
The study will be a randomized, open-label, cross-over clinical pharmacokinetic trial to investigate a strategy for probenecid "boosting" in the setting of tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for HIV…
- Trial name
- NCT03202511
- Testing
- Probenecid Oral Tablet, Tenofovir disoproxil fumarate/Emtricitabine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Indiana University
Kidney Stone, Surgery
Regional Erector Spinae Analgesic Block vs Standard of Care Undergoing Percutaneous Nephrolithotomy
The purpose of this study is to determine if adding a spinal block (medicine that will numb parts of the body to block pain) along with standard pain control at the incision site will decrease the need for narcotics for pain…
- Trial name
- NCT04663269
- Testing
- 4mg PF Dexamethasone, Control Test
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
HIV
Innovative Approaches for Minor Consent: Consent 2.0
The purpose of this study is to examine how the consent process affects the acceptability of participation in biomedical HIV prevention trials, from the perspective of behaviorally high-risk minors and the parents of minor…
- Trial name
- NCT03242954
- Testing
- Autonomous minor consent, Adult permission required, Parental permission required
- Where
- 4 sites in United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hernia
Hernia Repair With or Without Sutures
This is a randomized study between two accepted techniques of mesh fixation for laparoscopic hernia repair.
- Trial name
- SONS (NCT00905320)
- Testing
- Metallic Fasteners and Sutures, Metallic Fasteners Alone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Indiana University
Contraception
Effectiveness of Prolonged Use of IUD/Implant for Contraception
This study will evaluate LNG-IUD and Etonogestrel (ENG) Implant users who are willing to use their contraception beyond the end of the FDA-approved duration.
- Trial name
- EPIC (NCT02267616)
- Testing
- Etonogestrel Implant
- Where
- 2 sites in United States
- Volunteers
- 1,076 people, healthy volunteers welcome
- Sponsor
- Indiana University
Periodontal Diseases
Amnion-Chorion Allograft Barrier Used for Root Surface and Guided Tissue Regeneration
The purpose of this pilot project is to evaluate the efficacy of application of Amnion-Chorion allograft membrane on the root surface of periodontally diseased teeth in conjunction with bone substitute covered by Amnion-Chorion…
- Trial name
- NCT03095976
- Testing
- Amnion-Chorion allograft membrane on the root surface of periodontally diseased site.
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Indiana University
Prostate Cancer Recurrent
Sipuleucel-T and Low-protein Diet in Patients With Metastatic Castrate-resistant Prostate Cancer
This is a single-center, randomized, open-label study to assess the feasibility of a low-protein diet intervention in patients with metastatic castrate-resistant prostate cancer (CRPC) who are receiving treatment with…
- Trial name
- NCT03329742
- Testing
- Low protein diet, Control protein diet
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Indiana University