Clinical trials: sponsored by Indiana University
Muscular Dystrophy, Arrhythmia
Arrhythmias in Myotonic Muscular Dystrophy
Adult myotonic muscular dystrophy (Steinert's disease) is the most common inherited neuromuscular disorder. Cardiac rhythm disturbances occur frequently in this disease state and may be responsible for up to one-third of deaths.
- Conditions
- Muscular Dystrophy, Arrhythmia, Sudden Cardiac Death
- Trial name
- DM1 (NCT00622453)
- Testing
- Screening
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- Indiana University
Anterior Pelvic Ring Injury With Symphysis Disruption
Comparison of INFIX and Plating for Pelvic Ring Injuries With Symphysis Disruptions
The purpose of this study is to compare subcutaneous internal fixation and open plating of the symphysis in patients with a disruption of the symphysis requiring stabilization.
- Trial name
- NCT02399319
- Testing
- Internal Fixator, Symphyseal Plate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Sexually Transmitted Diseases
Aspiring to Awesome- Patient Preference Privacy Selections in EMR
Health information technology, including health information exchange, offers the potential to improve care by providing an integrated view of relevant, integrated patient information from multiple health care providers practicing…
- Trial name
- NCT01862133
- Testing
- Patient preferences
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Indiana University
Phantom Limb Pain
Massage Therapy for Phantom Limb Pain: Feasibility and Pilot Study
Massage therapy is a treatment self-reported by those with phantom limb pain (PLP) as moderately to extremely effective, but no research to date has been specifically designed to examine such efficacy or effectiveness in this…
- Trial name
- NCT03372668
- Testing
- massage therapy combined with components of mirror therapy
- Volunteers
- 3 people
- Sponsor
- Indiana University
Intermittent Exotropia
Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia
To determine the effectiveness of alternate occlusion therapy for the treatment of IXT among patients aged 3 to < 11 years old.
- Trial name
- CIAO (NCT02466659)
- Testing
- CIAO therapy Amblyz glasses
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Indiana University
Health Services Accessibility
Improving Healthcare Systems for Access to Care by Underserved Patients
The investigators seek to improve health systems so underserved people, patients without insurance, Medicaid, Medicare, as well as self pay and their caregivers can better access health care for common problems and acute care…
- Trial name
- PCORI (NCT02235597)
- Where
- 7 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV, Cardiovascular Diseases
Evaluating the Effectiveness of Pentoxifylline at Improving Blood Vessel Function in HIV-infected People Not Receiving Antiretroviral Medications
People infected with HIV have a greater risk of developing cardiovascular disease than people not infected with HIV. This may be due to increased inflammation brought on by either the HIV infection itself or the use of…
- Conditions
- HIV, Cardiovascular Diseases, Atherosclerosis
- Trial name
- NCT00796822
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Indiana University
Hemorrhage, Pain
Effect of Tonsillar Pillar Closure on Postoperative Pain and Bleeding Risk After Tonsillectomy
The purpose of this study is to determine if closing the tonsil fossa after tonsillectomy leads to less pain and bleeding risk than leaving it open to heal by secondary intention.
- Trial name
- NCT00394849
- Testing
- suture one tonsillar fossa
- Where
- United States
- Volunteers
- 763 people, healthy volunteers welcome
- Sponsor
- Indiana University
Peripheral Neuropathy
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Purpose: The purpose of the study is to test a new way of measuring nerve damage in women with breast cancer receiving chemotherapy drug paclitaxel (Taxol).
- Trial name
- NCT02549534
- Testing
- Axon Reflexes, Axon Flares, Self-Reported Signs & Symptoms of CIPN
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Endothelial Dysfunction
Effect of the HIV Protease Inhibitors Atazanavir and Lopinavir/Ritonavir on Cardiovascular Disease Risk Factors
HIV protease inhibitors (PIs) are a class of antiretroviral drugs used to inhibit viral replication. They do so by interfering with a key step in the replication process.
- Trial name
- NCT00720590
- Testing
- Atazanavir, Lopinavir/ritonavir
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Deep Vein Thrombosis
Incidence of Venous Thromboembolism in Children Undergoing Elective Neurosurgical Procedures
The purpose of this study is to determine how frequently children undergoing elective neurosurgical procedures develop blood clots in the deep veins of the legs while hospitalized.
- Trial name
- NCT02037607
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Healthy
CYP2B6 Genetics and Drug Interactions in Healthy Volunteers
The CYP2B6 enzyme metabolizes a growing number of clinically important drugs such as the anti-HIV drug efavirenz, but its activity in the liver is highly variable, which may lead to failure of therapy or toxicity and…
- Trial name
- NCT02401256
- Testing
- Efavirenz, Bupropion, Rosuvastatin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Type 1 Diabetes
Mobile Communication Technology for Adolescents With Diabetes
Among those with type I diabetes, adolescents can be among the worst at achieving glycemic control. Behaviors normal in adolescent development (e.g., developing independence, rejecting parental norms in favor of peers) can be at…
- Trial name
- NCT00605839
- Testing
- GlucoPak, Cell Phone, Usual Care
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Indiana University
Walled-off Necrosis
Comparing Fully Covered, Self Expanding Metal Stent (FCSEMS) and Plastic Stents for EUS- Guided Drainage of WON
This is a multi-center, single-blinded, randomized trial comparing AXIOS FCSEMS (Fully Covered Self Expanding Metal Stent) and plastic stents for EUS (Endoscopic Ultrasound)-guided management of infected and/or symptomatic WON…
- Trial name
- WON (NCT02718092)
- Testing
- Plastic Stent, Axios Fully Covered Self Expanding Metal Stent
- Sponsor
- Indiana University
Cigarette Smoking
Using Computers to Assist in Parental Smoking Cessation in a Pediatric Setting
The CHICA system is a clinical decision support system that uses adaptive turnaround documents to provide point-of-care information to clinicians.
- Trial name
- NCT01334216
- Testing
- CHICA Smoking Cessation Module
- Where
- United States
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Indiana University
Breast Cancer Female, Colorectal Cancer
Increasing Colorectal and Breast Cancer Screening in Women
This study compares the efficacy (adherence and stage) of four interventions to promote colorectal (CRC) and breast cancer (BC) screenings among women ages 50 to 75. They are: 1. usual care; 2.
- Trial name
- COBRA (NCT03279198)
- Testing
- TIWeb, CSC, UC
- Volunteers
- 1,196 people, healthy volunteers welcome
- Sponsor
- Indiana University
Traumatic Brain Injury
Memantine for Neuroprotection and Cognitive Enhancement Following Traumatic Brain Injury
The purpose of this study is to determine if memantine can improve cognitive and neuropsychiatric outcomes after severe traumatic brain injury.
- Trial name
- NCT02240589
- Testing
- Memantine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Indiana University
Nephrotoxicity
Switch From Calcineurin Inhibitor to Belatacept in Pancreas Transplant Recipients
Kidney damage is a major complication of current antirejection medicines used in transplantation. An increasing number of brittle diabetics are successfully receiving a pancreas transplant.
- Trial name
- NCT02103855
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Indiana University
Amblyopia
Comparison of AmblyzTM Glasses and Patching for Amblyopia
Electronic eyeglasses, Amblyz™glasses, are a new medical device designed to treat amblyopia, which intermittently become opaque and provide effective occlusion for 50% of the time they are worn.
- Trial name
- NCT01973348
- Testing
- 4-hour AmblyZ glasses, 12-hour AmblyZ glasses, 2-hour patching
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Indiana University
Gestational Diabetes Mellitus, Pre-diabetes
Encourage Healthy Families
This study is a randomized intervention that will test two different approaches reflecting diverse levels of both intensity and cost, to achieving risk reduction of T2D.
- Trial name
- Encourage (NCT01823367)
- Testing
- Diabetes Prevention Program (DPP)
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Indiana University
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