Clinical trials: sponsored by Indiana University
Crohn's Disease
Can CT Enteroclysis Predict the Outcome of Crohn's Disease
Specific CT Enteroclysis findings with or without other clinical and laboratory variables, can identify Crohn's disease patients who will response to medical therapy versus those who will either fail and require surgery or have…
- Trial name
- NCT00572780
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Indiana University
Arthritis, Rheumatoid, Vitamin D Deficiency
Vitamin D Deficiency Causes Immune Dysfunction and Enables or Perpetuates the Development of Rheumatoid Arthritis
Recent studies have demonstrated that subjects with low blood levels of vitamin D are at a higher risk of developing autoimmune diseases such as Rheumatoid Arthritis (RA).
- Trial name
- NCT00279461
- Where
- United States
- Sponsor
- Indiana University
Headache, Migraine
Sphenopalatine Nerve Block for Headache Tx360
The primary objective of this study is to evaluate the efficacy of sphenopalatine nerve block utilizing the Tx360 (device) to deliver an anesthetic agent (bupivacaine) and to assess the duration of the analgesia.
- Trial name
- NCT01939314
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Indiana University
Ductal Carcinoma in Situ
Lapatinib for Treatment of Ductal Carcinoma In Situ (DCIS) of the Breast
The purpose of this study is to establish the utility of lapatinib in the treatment of DCIS, particularly ER-negative DCIS.
- Trial name
- NCT00857714
- Testing
- lapatinib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Indiana University
Adult Central Nervous System Germ Cell Tumor, Adult Teratoma
Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors
This phase II trial studies how well palifosfamide works in treating patients with recurrent germ cell tumors. Drugs used in chemotherapy, such as palifosfamide, work in different ways to stop the growth of tumor cells, either by…
- Conditions
- Adult Central Nervous System Germ Cell Tumor, Adult Teratoma, Malignant Extragonadal Germ Cell Tumor, Malignant Extragonadal Non-Seminomatous Germ Cell Tumor
- Trial name
- NCT01808534
- Testing
- palifosfamide
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
Glaucoma, Cataract
A Comparison of Three Different Formulations of Prednisolone Acetate 1%
Generic prednisolone acetate 1% is less effective than Pred Forte 1% or Econopred Plus 1%.
- Trial name
- NCT00345046
- Testing
- Pred Forte, EconoPred Plus, Prednisolone Acetate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Attention Deficit Disorder With Hyperactivity
Quetiapine and Concerta in the Treatment for ADHD and Aggressive Behavior.
The primary purpose of this thirteen-week, open-label study is to test the hypothesis that quetiapine in combination with Oros methylphenidate will reduce aggressive symptoms in children and adolescents who have shown inadequate…
- Trial name
- NCT00550147
- Testing
- Oros Methylphenidate, quetiapine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Abnormal Uterine Bleeding
Decisionmaking for Abnormal Uterine Bleeding (AUB)
The purpose of this study is to determine if using a computer survey about preferences for treatment of abnormal uterine bleeding (AUB) is useful and if it will improve patient satisfaction with clinical care and decision making.
- Trial name
- NCT01721304
- Testing
- Adaptive Conjoint Analysis
- Where
- 2 sites in United States
- Volunteers
- 380 people
- Sponsor
- Indiana University
Hepatocellular Carcinoma
A Phase Ib Study of Stereotactic Body Radiotherapy (SBRT) Plus Sorafenib in Patients With Unresectable Hepatocellular Carcinoma (HCC)
This is a research study of a radiation treatment called stereotactic body radiotherapy (SBRT) plus a medicine called sorafenib.
- Trial name
- NCT01801163
- Testing
- Sorafenib, Stereotactic radiotherapy
- Where
- United States
- Sponsor
- Indiana University
Breast Cancer
The Role of Serotonin in Hot Flashes After Breast Cancer
The purpose of this proposal is to improve our understanding of the role of tryptophan and serotonin in hot flashes. The main hypothesis is that alterations in tryptophan and serotonin levels are involved in the induction of hot…
- Trial name
- NCT00228943
- Testing
- Acute tryptophan depletion, Half-strength tryptophan depletion (Control)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Indiana University
Smoking Cessation
Technology-Enhanced Quitline Services to Prevent Smoking Relapse
The purpose of this study is to see if automated telephone monitoring will enhance existing quitline services, such as Alere Wellbeing's Quit For Life program, and help people quit smoking.
- Trial name
- TEQ (NCT00888992)
- Testing
- Quitline Service + 10 automated monitoring calls, Quitline service + 20 automated monitoring calls
- Where
- United States
- Volunteers
- 1,785 people, healthy volunteers welcome
- Sponsor
- Indiana University
Inflammatory Bowel Disease, Crohn's Disease
Levels of the Stat4 Alpha and Stat4 Beta Isoforms in PBMCs From Patients With Crohn's Disease and Ulcerative Colitis
The goal in these studies will be to assess the relative levels of the Stat4 alpha and Stat4 beta isoforms in PBMCs from patients with Crohn's Disease, ulcerative colitis, celiac disease or from control patients.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT00586599
- Testing
- measurement of inflammatory markers
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Indiana University
Stroke, Family Caregivers
Telephone Assessment and Skill-Building Intervention for Stroke Caregivers
The purpose of this study is to test the efficacy of the revised Telephone Assessment and Skill-Building Kit (TASK II) compared with an Information, Support, and Referral (ISR) intervention in family caregivers of stroke…
- Trial name
- TASKII (NCT01275495)
- Testing
- Telephone Assessment and Skill-Building Kit (TASK II), Information, Support, and Referral (ISR)
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Indiana University
Chronic Acalculous Cholecystitis
The Influence of Ezetimibe on Gallbladder Function
Ezetimibe is a drug which inhibits the absorption of both dietary and biliary cholesterol in the small intestine. Ezetimibe has been approved for use in humans to lower serum cholesterol.
- Trial name
- NCT00634140
- Testing
- ezetimibe
- Where
- United States
- Sponsor
- Indiana University
Normal
System for Ocular Oxygen Measurement
The purpose of this study is to demonstrate the ability of the OcuMetrics system to measure oxygen on the surface of the eye. Oxygen is important to the health of the cornea.
- Trial name
- NCT01229488
- Testing
- Intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Bone Marrow Suppression, Brain and Central Nervous System Tumors
Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Bone Marrow Suppression, Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ
- Trial name
- NCT00005796
- Testing
- filgrastim, gene therapy, lomustine
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Healthy Children Undergoing Routine Care, Children With Autism
Study of the Effectiveness of a Computer Decision Support System to Improve Physicians' Screening for Autism
The investigators hypothesize that children seen in a clinic that uses a compute based system known as CHICA, which reminds pediatricians to screen at defined time point for autism, will be screened more consistently for autism…
- Trial name
- CAAC (NCT01612897)
- Testing
- Computer based care reminders
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- Indiana University
Dental Caries
Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Caries means demineralization with the formation of cavities and pulp symptoms and necrosis as an end result. The acids in the mouth are mainly produced by oral bacteria like Streptococcus mutans from bacterial biofilms adhering…
- Trial name
- NCT00495495
- Testing
- Ozone treatment
- Where
- 3 sites in United States
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hodgkins Disease
Breast-Sparing Proton Therapy for Hodgkin's Disease
The purpose of this study is to drastically reduce unnecessary breast dose in young females with Hodgkin's Disease who require radiation therapy.
- Trial name
- Breast Sparing (NCT02070393)
- Testing
- Proton
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Indiana University
Healthy
Rapid Screening Phenotype Test To Evaluate CYP 2C19 Enzyme Activity Using Stable Isotope [13C]Pantoprazole
The purpose of this study is to determine the function of an enzyme that breaks down drugs and helps the removal of drugs from your body. This enzyme is called cytochrome P450 2C19 and is located in your liver.
- Trial name
- NCT00668902
- Testing
- [13C]Pantoprazole
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Indiana University
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