Clinical trials: sponsored by Indiana University
Ocular GVHD
The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients
The Investigators hypothesize that the recalcitrant nature of ocular GVHD may be related to corneal nerve damage and corneal hypoesthesia.
- Trial name
- NCT04700657
- Testing
- corneal sensation test
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Idiopathic Bronchiectasis
Primary Ciliary Dyskinesia in Adult Bronchiectasis
The purpose of this study is to help determine how often primary ciliary dyskinesia (PCD) is present but undiagnosed in adults with bronchiectasis.
- Trial name
- NCT07566611
- Testing
- Nasal Nitric Oxide Measurement, Nasopharyngeal (Nasal) Samples
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Squamous Cell Carcinoma of the Oropharynx, HPV Positive Oropharyngeal Squamous Cell Carcinoma
Adjuvant Treatment Deintensification After Transoral Surgery for Human Papillomavirus-Positive Squamous Cell Carcinoma
Oropharyngeal squamous cell carcinoma (OPSCC), commonly known as throat cancer or tonsil cancer, has seen a dramatic rise in incidence over the last twenty years.
- Trial name
- NCT05119036
- Testing
- 44 doses of radiation, 54 doses of radiation
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- Indiana University
Mild Cognitive Impairment, MCI
Neuromodulation of Memory in Aging
The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states.
- Trial name
- TMS-AD (NCT05460468)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Indiana University
Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer
ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the Oropharynx
This study is a prospective phase II trial, designed to assess the efficacy and feasibility of adjuvant treatment deintensification guided by ctHPVDNA levels for patients with HPV+OPSCC who undergo transoral surgery and neck…
- Conditions
- Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer, Throat Cancer, Tonsil Cancer
- Trial name
- NCT06915038
- Testing
- NavDx, Adjuvant Radiation 30 Gray, Adjuvant Radiation 40 Gray
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Hiv, Transmission Vertical
Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV
Mentor Mothers (MMs) are peer supporters who help pregnant and postpartum women living with HIV (WLHIV) as they receive prevention of mother-to-child transmission of HIV (PMTCT) services in resource-limited settings like Kenya.
- Conditions
- Hiv, Transmission Vertical, Viremia, Adherence, Treatment
- Trial name
- PIE-eMMs (NCT06999928)
- Testing
- Enhanced Mentor Mother Strategy
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
Chronic Kidney Disease Stage 3
Effects of Replacing High Protein Foods in People With Chronic Kidney Disease
The goal of this crossover clinical trial is to explore the effects of red meat intake on serum and fractional urinary excretion of uremic toxins including trimethylamine N-oxide in people with chronic kidney disease.
- Trial name
- NCT07105670
- Testing
- Controlled dietary intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Traumatic Brain Injury, Concussion, Intermediate
Intervention to Change Affect Recognition and Empathy
Determine the feasibility, practicality, and early efficacy of a TeleRehab program (ICARE) to improve outcomes for persons with traumatic brain injury (TBI) in recognizing and responding to others' emotions alongside their care…
- Conditions
- Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes
- Trial name
- ICARE (NCT05636020)
- Testing
- ICARE Treatment
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Indiana University
Insomnia, Insomnia Chronic
SHADES Mechanistic Trial
Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future.
- Conditions
- Insomnia, Insomnia Chronic, Insomnia, Primary, Sleep Disturbance
- Trial name
- SHADES (NCT06041581)
- Testing
- Sleep Healthy Using The Internet (SHUTi), Telephonic CBT-I, Face-to-Face CBT-I
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Regulation of Energy Expenditure
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1
Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue…
- Trial name
- NCT07030725
- Testing
- Menthol Gel, Time control
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Comparing Approaches to Helping People With Chronic Traumatic Brain Injury Manage Their Health Care
The goal of this double-masked, randomized control trial is to learn about the potential benefits of two different strategies at helping people with traumatic brain injury who see a brain injury physician be more engaged in their…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, TBI
- Trial name
- 2BeHealthy (NCT07483528)
- Testing
- Patient Priorities Care (PPC), Resource Education
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Indiana University
Graves Disease, Hashimoto Disease
Preoperative Corticosteroids in Autoimmune Thyroid Disease
This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery…
- Trial name
- NCT05435547
- Testing
- Dexamethasone
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Indiana University
Autism
Expanding Autism Diagnostic Biomarkers to Kenya
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures.
- Trial name
- KinleyET (NCT06685822)
- Testing
- Eyelink Portable Duo
- Where
- Kenya
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Indiana University
Management of Ischemic Stroke, Medium Vessel Occlusion
PROMISE Registry: PROspective Study on Management of Ischemic Stroke Secondary to mEvo Registry
Investigators are conducting a real world, observational, prospective, multicenter study to better understand treatment for patients with MeVo and distal vessel occlusions in the U.S post publication of recent MeVO trials.
- Trial name
- NCT07746947
- Where
- United States
- Volunteers
- 652 people
- Sponsor
- Indiana University
Diabetes (DM), Nutrition
Impact of Food as Medicine Glycemic Control at Two Large Academic Medical Centers
The primary purpose of this study is to determine if the implementation of a food as medicine program would improve clinical outcomes when integrated into routine care at two large academic hospitals. 1.
- Trial name
- NCT07748286
- Testing
- Food as Medicine Eskenazi, Indiana Health NourishedRX
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Coagulopathy
Validation of Point-of-care Thromboelastography (TEG 6s) in Pediatric Patients
The goal of this observational study is to learn about the performance of the TEG6s in normal pediatric patients. The main questions it aims to answer are: What are the normal TEG 6S lab results in normal pediatric patients and…
- Trial name
- NCT05874843
- Testing
- Thromboelastography (TEG 6S)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Indiana University
Mild Cognitive Impairment (MCI), Alzheimer Disease
Innovative Cognitive Impairment Case Finding and Engagement for Diverse Participation in Alzheimer's Disease Care, Treatment, And Research
Recent studies have highlighted the potential use of electronic health record (EHR) data for scalable and less biased identification of people who may have or be at risk of developing MCI or ADRD at the population level.8,9 Using…
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Dementia
- Trial name
- INCLUDE (NCT07016178)
- Testing
- Acceptability and Feasibility of Twistle messaging for PDM+ patients
- Where
- United States
- Volunteers
- 3,454 people
- Sponsor
- Indiana University
Dementia, Alzheimer Disease, Late Onset
Reducing Risk of Dementia Through Deprescribing
A cluster-randomized controlled trial (RCT) called "Reducing Risk of Dementia through Deprescribing" (R2D2) to evaluate the impact of a deprescribing intervention on important cognitive and safety outcomes.
- Trial name
- R2D2 (NCT04270474)
- Testing
- Deprescribing of target anticholinergics, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 344 people
- Sponsor
- Indiana University
Implementation Science, Heart Transplant
Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies Trial
The primary goal of this study is to assess real-world effectiveness and implementation of an evidence-based multi-component strategy to reduce disparities in the allocation rate of advanced heart failure therapies, heart…
- Conditions
- Implementation Science, Heart Transplant, Decision Making
- Trial name
- SOCIAL HF (NCT05390411)
- Testing
- SOCIAL HF
- Where
- United States
- Volunteers
- 1,463 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alzheimer Disease and Related Dementias (ADRD)
Digital Detection of Dementia (D Cubed) Studies: D3
The specific aim of the pragmatic trial is to evaluate the practical utility and effect of the PDM, the QDRS, and the combined approach (PDM + QDRS) in improving the annual rate of new documented ADRD diagnosis in primary care…
- Trial name
- NCT06224205
- Testing
- Passive Digital Marker for screening for ADRD
- Where
- United States
- Volunteers
- 1,281 people
- Sponsor
- Indiana University