Clinical trials: sponsored by Institut Paoli-Calmettes
Nonresectable Bile Duct Cancer
Prospective Evaluation of the Ablation Therapy With Bipolar Radio Frequency for Nonresectable Bile Duct Cancer
90 % of the patients with bile duct cancer are not justifiable of a surgical resection with curative aim for oncologic reasons ( metastatic extensions), for reasons of resectability (canalar extension, vascular) or still for…
- Trial name
- RFA-BILIAIRE (NCT03679338)
- Testing
- Ablation Therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut Paoli-Calmettes
Colorectal Adenoma
Panoramic Screening by Complete Colonoscopy in the Management of Colorectal Adenomas
Colonoscopy is the gold standard for colorectal cancer prevention by allowing the resection of superficial colorectal adenomas or adenocarcinomas.
- Trial name
- G-EYE-ADR (NCT03961893)
- Testing
- G-EYE first and standard colonoscope, standard colonoscope first and G-EYE
- Where
- France
- Volunteers
- 164 people
- Sponsor
- Institut Paoli-Calmettes
Pancreatic Cancer Non-resectable
PANCREATIC CANCER: DYNAMIC ASSESSMENT AT ALL STAGES OF TREATMENT
The study consists of a 25 ml blood sample collection: Before the start of treatment Approximately 2 months after the start of induction chemotherapy At the end of induction chemotherapy Prior to local treatment (radiotherapy…
- Trial name
- NCT05802485
- Testing
- collection of blood and tumor samples
- Volunteers
- 300 people
- Sponsor
- Institut Paoli-Calmettes
Hematologic Cancer
Collection of Sequential Samples From Patients With Malignant Myeloid Hemopathy for the Study of Treatment Resistance
The main objective is to study the genomic, transcriptomic, proteomic epigenomic, metabolomic and immune mechanisms of blasts and microenvironment cells associated with IT resistance through the constitution of a collection…
- Trial name
- NCT05602168
- Testing
- experimental:Acute leukemia/myelodysplastic or myeloproliferative disease
- Volunteers
- 400 people
- Sponsor
- Institut Paoli-Calmettes
Hematological Cancer
Evaluation of the Impact of Sports-inspired Onco-coaching on Health-related Quality's Life of the Patients in Cancer Remission After Allogeneic Transplantation of Hematopoietic Stem Cells
To measure the impact of a coaching program on the patient's health-related quality of life 15 months post-transplant (M15/R12).
- Trial name
- NCT05486273
- Testing
- interviews with coachs, semi-structured interviews and questionnaires, semi-structured interviews and questionnaires
- Volunteers
- 108 people
- Sponsor
- Institut Paoli-Calmettes
Breast Cancer
A Phase 1b/2 Trial Evaluating Safety and Efficacy of CAPecitabine in Combination With Ni-rapaRIb in HER2-negative Advanced Breast canCEr
This study will be to combine oral capecitabine and oral niraparib such thz association may increase clinical benefits of PARP inhibitors in germline BRCA mutated HER2 negative advanced breast cancer patients.
- Trial name
- CAPRICE (NCT05519670)
- Testing
- Niraparib Oral Product
- Volunteers
- 72 people
- Sponsor
- Institut Paoli-Calmettes
Pancreas Cancer, Pancreatectomy; Hyperglycemia
Evaluation of the Impact of Pancreatectomy on Systemic Immunity
The study aims at establishing the profile of the immune reaction that occurs in the early surgical suites after pancreatectomy.
- Trial name
- IMMUNOPANC (NCT03978702)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut Paoli-Calmettes
Hematologic Neoplasms
Immunological Profile for Patients Treated With CAR-T Cells
In the frame of Si-CART study, blood will be collected from patients treated with CAR-T cells: before (at Day (D)-6 and D0 before cells injection), post infusion at D3, D5,D7, D9, D11, D14, D18, D 21, Month (M) 2 and M12 post…
- Trial name
- SI-CART (NCT05054231)
- Testing
- Blood sample collection
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Institut Paoli-Calmettes
Cancer
COVID-19 and Reorganisation of Cancer Patient Care: Self- Evaluation of Potential Post-traumatic Stress Disorder
The COVID-19 pandemic is a traumatic event which could lead to a greater risk of developing post-traumatic stress disorder, especially in cancer patients who feel more at risk of contracting the virus, and fear developing serious…
- Trial name
- COVID-TRAUMA (NCT04401046)
- Testing
- Survey to assess Post traumatic stress and anxiety at inclusion and 6 months later
- Where
- France
- Volunteers
- 1,096 people
- Sponsor
- Institut Paoli-Calmettes
Pancreas Neoplasm
The Neutrophil-to-Lymphocyte Ratio to Exclude Pancreatic Fistula
There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF).
- Trial name
- NLR (NCT04724551)
- Testing
- pancreatoduodenectomy (PD)
- Volunteers
- 648 people
- Sponsor
- Institut Paoli-Calmettes
Rectal Adenocarcinoma
Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems
feasibility of using a diffusion sequence of a MRgRT system as an early marker of treatment response during nRCT of rectal adenocarcinoma.
- Trial name
- DWI_RECT_MRGRT (NCT03961776)
- Testing
- MRI-guided radiotherapy by on-board DWI sequences
- Where
- 2 sites in United States, France
- Volunteers
- 39 people
- Sponsor
- Institut Paoli-Calmettes
Barrett Esophagus Adenocarcinoma
Impact of an Endoscopic Treatment of the Line Z on the Gastronomic Recurrence and the Gastro- Esophageal Reflux Disease in the Care of the Adenocarcinoma of Barrett's Oesophagus
Barrett's oesophagus is a transformation of the esophageal mucous membrane there intestinal metaplasia under the effect of gastro- esophageal reflux disease (GERD).
- Trial name
- B-ARMS (NCT03278327)
- Testing
- Complete endoscopic resection at Day 1 and months 2, 4, 6 8 and month 10., Endoscopic resection at month 2 and month 4
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Paoli-Calmettes
Colorectal Cancer
Tumoral Circulating Cells and Colorectal Cancer Progression
Prospective research of circulating tumor cells as markers of progression risk in colorectal cancer.
- Trial name
- NCT03256084
- Testing
- Blood and tumor samples
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institut Paoli-Calmettes
Pancreatic Cancer
Evaluation of Complete microscopicE Resection Margin (R0) and Lymph Node Involvement After Standard Pancreatosplenectomy (SPS) Versus Radical Anterograde Modular Pancreatosplenectomy
Resection with negative margins (R0) followed by adjuvant chemotherapy is today the standard of care and the only chance of cure for patients with pancreatic ductal adenocarcinoma (PDA).
- Trial name
- REMIND-01 (NCT03679169)
- Testing
- pancreatosplenectomy
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Institut Paoli-Calmettes
Hematologic Cancer
TORQUETENOVIRUS IN CAR-T THERAPY: PREDICTION OF THE CRS
Torque Teno Virus (TTV) prevalence in the general population is very high (>90%) and has not been consistently confirmed to cause any disease.
- Trial name
- TTV-CART (NCT04822974)
- Testing
- blood collection
- Volunteers
- 20 people
- Sponsor
- Institut Paoli-Calmettes
Neuroendocrine Tumors
Ki67 Proliferation Index of Pancreatic Neuroendocrine Neoplasia
This is a retrospective, monocentric study involving 50 patients with pancreatic neuroendocrine neoplasia resected between January 2008 and June 2020 at Paoli Calmettes Institute.
- Trial name
- TNE-P-Ki (NCT04753229)
- Volunteers
- 50 people
- Sponsor
- Institut Paoli-Calmettes
Ovarian Cancer
Connected Prehabilitation Program During Neo Adjuvant Chemotherapy
NACT is a heavy oncologic treatment, which can impair functional capacity, nutritional and emotional status. These three impairments are often ignored and not taken into account in the pre-therapeutic evaluations but are…
- Trial name
- TRAINING (NCT04451369)
- Testing
- Prehabilitation program
- Volunteers
- 136 people
- Sponsor
- Institut Paoli-Calmettes
Anastomosis; Complications, Pancreatic Fistula
Pancreaticogastrostomy for High-Risk Pancreas
In 2013, a double purse-string telescoped pancreaticogastrostomy (PG) technique appeared to significantly reduce the risk of postoperative pancreatic fistula (POPF).
- Trial name
- GASTROPAN (NCT04724174)
- Testing
- pancreaticogastrostomy, pancreaticojejunostomy
- Volunteers
- 198 people
- Sponsor
- Institut Paoli-Calmettes
Colorectal Disorders
Prospective Database for Colonic or Rectal Resection Surgery Patients
Colorectal cancer is the third most common cancer in men, after prostate and lung cancer. It represents 11.2% of all new cases of male cancer.
- Trial name
- CHIRCOLREC (NCT04704817)
- Testing
- obsevation
- Volunteers
- 1,000 people
- Sponsor
- Institut Paoli-Calmettes
Acute Leukemia, Mielodysplasic Syndrome
Sequential and Personalized PK-guided Busulfan Administration in the Frame of the Conditiong Regimen for Allo-HSCT in Patients With Malignant Hemopathies Ineligible for the Standard Myeloablative Conditioning
Because the anti-leukemic activity of busulfan, this dug is largely used in graft conditioning but in elderly and/or cormobid patienth an excess of toxicity is observed.
- Conditions
- Acute Leukemia, Mielodysplasic Syndrome, Myeloproliferative Neoplasm
- Trial name
- BUSEQ (NCT04451200)
- Testing
- Busulfan Injection
- Volunteers
- 82 people
- Sponsor
- Institut Paoli-Calmettes