Clinical trials: sponsored by Institut Paoli-Calmettes
Stomach Neoplasms, Cardia
Institut Paoli Calmettes Cardia Cancer Database
Database of Institut Paoli-Calmettes patients diagnosed with cardia cancer
- Trial name
- NCT02869477
- Testing
- Data collection
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Institut Paoli-Calmettes
UTERINE CERVICAL NEOPLASMS, ENDOMETRIAL NEOPLASMS
Cost-Effectiveness and Patients Satisfaction of Conventional vs Robotic-Assisted Laparoscopy in Gynecologic Oncologic Indications
Laparoscopic surgery is gaining currency in the field of oncologic care, particularly for colorectal and gynecologic cancers. This innovation could be used either for staging purpose and therefore could steer global therapeutic…
- Trial name
- NCT02865889
- Testing
- Laparoscopy in Gynecologic Oncologic Indications, Conventional surgery (abdominal radical surgery)
- Where
- France
- Volunteers
- 343 people
- Sponsor
- Institut Paoli-Calmettes
Acute Myeloid Leukemia
Molecular Characterization of Acute Erythroid Leukemia (M6-AML) Using Targeted Next-generation Sequencing
Acute erythroid leukemia (AEL) is a morphologically distinct, infrequent (o5%) acute myeloid leukemia (AML) designed as M6 in the French- American-British (FAB) classification.
- Trial name
- NCT02861651
- Testing
- DNA sequencing
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut Paoli-Calmettes
Multiple Myeloma
Economic Evaluation of the Use of Plerixafor for Autologous HSC Transplantation for Multiple Myeloma
This study aims to realize an economic evaluation of the introduction of Plerixafor in addition to G-CSF and alternative options, in patients with multiple myeloma (MM) who failed or insufficiently mobilize peripheral blood stem…
- Trial name
- PLERIXAFOR (NCT02861287)
- Testing
- Economic evaluation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Paoli-Calmettes
Acute Myeloid Leukemia
Role of PTK-7 in Acute Myeloid Leukemias
The pseudo tyrosine kinase receptor 7 (PTK7) is an orphan tyrosine kinase receptor assigned to the planar cell polarity pathway. PTK7 is expressed in normal myeloid progenitors and CD34(+) CD38(-) bone marrow cells in humans.
- Trial name
- LAM-PTK7 (NCT02860793)
- Testing
- Bone marrow aspiration, Blood sampling
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Institut Paoli-Calmettes
Pancreatic Neoplasms
Onco-geriatric Database of Patients With Pancreatic Cancer
This data base has been set in order to gather oncogeriatric information from elderly patients with pancreatic cancer who underwent an oncogeriatric evaluation.
- Trial name
- NCT02858141
- Testing
- Data collection
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Institut Paoli-Calmettes
Leukemia, Myeloid, Acute
ChEmo-Genomics Based Treatment of Acute Myeloid Leukemia
Adult acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy associated with poor prognosis, especially after relapse.
- Trial name
- CeGAL (NCT02619071)
- Testing
- Tumor sampling, Constiutional DNA sampling
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Institut Paoli-Calmettes
Cancer
Adaptated Physical Activity During Chemotherapy: Evaluation of the Psychological, Physiological and Biological Impact
Although treatments significantly increase the life expectancy of cancer patients, their quality of life is more or less reduced.
- Trial name
- APA2 (NCT02785341)
- Testing
- questionnaires every 6 weeks (T0, T1, T2, T3 and T4), 6-minute walk test) every 6 weeks (T0, T1, T2, T3 and T4), leptin level with a blood test every 12 weeks (T0, T2 and T4)
- Volunteers
- 5 people
- Sponsor
- Institut Paoli-Calmettes
Jaundice
Prospective Randomized Study of PTC and EUS-guided Drainage of the Bile Duct
At this time, endoscopic retrograde cholangiopancreatography (ERCP) stay the gold standard method to achieve biliary drainage in case of malignant or benign stricture.
- Trial name
- NCT01499537
- Testing
- biliary drainage, EUS guided biliary drainage
- Where
- 3 sites in France, Monaco
- Volunteers
- 65 people
- Sponsor
- Institut Paoli-Calmettes
Adenocarcinoma of Head of Pancreas
Trial Evaluating the Efficacy of Laying a Biliary Stent for Producing a Heavy Chemotherapy in Unresectable Pancreatic Adenocarcinomas
For many years, the treatment of jaundice due to head pancreatic adenocarcinoma is based on the endoscopic biliary stent. This technique has been shown to be preferable to a surgical shunt.
- Trial name
- PROPAC (NCT02487836)
- Testing
- Type WallFlex or Evolution biliary, stent system
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Institut Paoli-Calmettes
Acute Myeloid Leukemia or Myelodysplasic Syndrome
Pilot Study Immunomonitoring Natural Killers Cells in Patients With Myeloid Malignancies Treated With Lenalidomide
This project is a framework for developing new therapeutic strategies for acute myeloid leukemia(AML)based immunotherapy. the role of NK cells was demonstrated in AML and especially GVL effect (graft versus leukemia) during…
- Trial name
- NCT02525250
- Testing
- Realization of 3 Blood samples during study during treatment with lenalidomide
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Institut Paoli-Calmettes
Androgen-independent Prostate Cancer
Analysis of the Mechanisms of Actions of Heat Shock Protein (Hsp27) Responsible of the Androgen-independent Evolution in Prostate Cancer
Prostate cancer (PC) represents one of the most common cancers in industrialized countries. Patients with localized disease may be treated with surgery or radiation, while androgen ablation is used as first-line therapy in…
- Trial name
- NCT02055846
- Testing
- Realisation of blood sample, urinary sample and tumor biopsy
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Institut Paoli-Calmettes
Pancreas, Adenocarcinoma
Prospective Evaluation of the Resection Margins and the Ganglionic Status Using a Quality Standard Resection for Adenocarcinoma of the Head of the Pancreas
This multicentric prospective study evaluates the role of the margins resection and the ganglionic status when using a quality standard for the resection of adenocarcinoma of the head of the pancreas.
- Trial name
- MRP (NCT00918853)
- Testing
- resection of adenocarcinoma of the head of the pancreas
- Where
- 20 sites in France
- Volunteers
- 156 people
- Sponsor
- Institut Paoli-Calmettes
Acute Myeloid Leukemia, Chronic Myeloid Leukemia
Phase I/II Study of Immune Therapy After Allograft in Patients With Myeloid Hemopathy
Patients with acute or chronic myeloid leukemia, or myelodysplastic syndrome, underwent allogeneic stem cell transplantation from HLA-identical donor (related or unrelated) after reduced-intensity conditioning regimen.
- Conditions
- Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Myelodysplastic Syndrome
- Trial name
- ALLO-WT1 (NCT01819558)
- Testing
- recwt1-A10+AS01B
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Institut Paoli-Calmettes
Chronic Lymphocytic Leukemia
Tolerance and Efficacy of Subcutanous Low Doses Rituximab for CLL Consolidation Treatment
Chronic Lymphocytic Leukemia (CLL) is still an incurable disease. However recent advances have established correlation between the quality of the response (in particular achievement of negativity of minimal residual disease (MRD)…
- Trial name
- LLCRlowdoz (NCT01521689)
- Testing
- Rituximab
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Institut Paoli-Calmettes
Pancreas Cancer
NEOadjuvant Gemcitabine/Oxaliplatin Plus Adjuvant Gemcitabine in Resectable PAncreatic Cancer
The aim of this study is to test the additional value of neoadjuvant chemotherapy to the standard treatment for resectable pancreatic cancer (surgery + adjuvant chemotherapy).
- Trial name
- NEOPAC (NCT01521702)
- Testing
- Neoadjuvant chemotherapy, surgery and Adjuvant chemotherapy
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Institut Paoli-Calmettes
Breast Cancer
Triple Negative Breast Cancer: Study of Molecular and Genetic Factors
Breast cancer triples negatives (TN; 15 % of the cases) are characterized by a high histoprognostic grade, a strong proliferation, a strong metastatic power, and a worse prognosis than the other forms of breast cancer.
- Trial name
- NCT01434420
- Testing
- BRCA1 BRCA2 PTEN PALB2 mutation
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Institut Paoli-Calmettes
Allograft, Allogeneic Cell Transplantaion
A Study Comparing Non Myeloablative (Flu-TBI) and Reduced Intensity (FLU-BU-ATG) Conditioning in Allogenic Transplantation
This study is a prospective comparison between 2 popular regimens based on reduced intensity or non-myeloablative approaches to define the optimal myeloablative and/or immu-nonsuppressive association for reduced intensity…
- Conditions
- Allograft, Allogeneic Cell Transplantaion, Hematological Malignancy, Solid Tumor
- Trial name
- ITAC02-01 (NCT00894049)
- Testing
- reduced intensity conditionings
- Where
- 5 sites in France
- Volunteers
- 148 people
- Sponsor
- Institut Paoli-Calmettes
Acute Myeloid Leukemia
Program of Evaluation and Geriatric Intervention on the Functional Status, Quality of the Life, and Survival
Acute myeloid leukaemia (AML) is a disease of the elderly, with a median age at diagnosis of 65. A poor outcome in this population has been well established, with very short overall survival (OS) and disease free survival…
- Trial name
- MLSP (NCT01188330)
- Testing
- WITH Comprehensive Geriatric assessment, Conventional
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Institut Paoli-Calmettes
Pancreas Neoplasms, Bile Duct Diseases
Intra-ductal Confocal Endomicroscopy for Characterization of Pancreas and Bile Duct Tumor
The endomicroscopy is an adaptation of traditional optical microscopy in the digestive endoscopy. Furthermore, with the integration of a miniaturized laser confocal microscope to a videoendoscope, it's possible to study the…
- Trial name
- EMID (NCT00930410)
- Testing
- Endoscopic Retrograde Cholangio-Pancreatography (ERCP)
- Where
- 2 sites in France, Monaco
- Volunteers
- 50 people
- Sponsor
- Institut Paoli-Calmettes