Clinical trials: sponsored by Istituto Clinico Humanitas
Infertility Assisted Reproductive Technology
From a Single Child to Family Planning
This monocentric retrospective cohort study aims to investigate reproductive behavior and subsequent family-building outcomes in couples who achieved a first live birth through assisted reproductive technology (ART) at a…
- Trial name
- FromSich (NCT07458165)
- Volunteers
- 5,852 people
- Sponsor
- Istituto Clinico Humanitas
Non Small Cell Lung Cancer, Pulmonary Stereotactic Radiotherapy
Stereotactic Body Radiotherapy (SBRT) for Reirradiation of Inoperable Lung Lesions
Radiotherapy (radiation treatment) is often used to treat lung cancers and lung tumors that have spread from other cancers. It can be very effective, especially in early-stage lung cancer or when there are only a few tumor sites.
- Trial name
- NCT07401615
- Where
- 11 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Clinico Humanitas
Breast Cancer, Oligometastasis
stereOtactic Body RadIothErapy for exTracranial oligomeTastAtic Breast Cancer: Multi Institutional Retrospective Database
Oligometastatic breast cancer is a condition in which breast cancer has spread to a small number of other parts of the body. Patients with this type of disease may live longer than those with more widespread metastases.
- Trial name
- ORIETTA (NCT07397585)
- Where
- 28 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
Partial Meniscectomy, Knee Arthroscopic Surgery
Video-Based Education Versus In-Person Education in Patients Undergoing Arthroscopic Partial Meniscectomy
The primary aim of the study is to investigate whether video-based education and exercise-program is non-inferior to in-person instructions in improving pain-related self-efficacy in patients undergoing arthroscopic partial…
- Trial name
- NI-RCT (NCT07358325)
- Testing
- Video-based education, Usual Care
- Where
- Italy
- Volunteers
- 166 people
- Sponsor
- Istituto Clinico Humanitas
Rectal Cancer Patients, Rectal Cancer Surgery
Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen Extraction
Natural Orifice Specimen Extraction (NOSE) eliminates the need for additional abdominal incisions in minimally invasive colorectal procedures, potentially reducing the risk of wound complications and postoperative pain.
- Trial name
- NOSE (NCT07358247)
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Istituto Clinico Humanitas
Cancer, Proton Therapy
HUmanitas PROtontherapy (HU-PRO)
Proton therapy is a cancer treatment, similar to the more commonly used radiation therapy. It uses radiation to destroy cancer cells and helps control the disease in the treated area.
- Trial name
- HU-PRO (NCT07317245)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Renal Cancer
Prospective Observational Trial of Image-guided Ablative STereotactic bOdy Radiation Therapy for Primary kidNey Cancer: the STONE Trial
The study objective is to evaluate the use of Stereotactic Body Radiotherapy (high dose of radiation in a few fractions) to cure primary renal cancer in those patients that are not indicated to surgery (high risk of…
- Trial name
- NCT07299357
- Testing
- Stereotactic body radiotherapy (SBRT)
- Where
- 2 sites in Italy
- Volunteers
- 53 people
- Sponsor
- Istituto Clinico Humanitas
Hematological Disease
AI Algorithms to Automate the TMI by VMAT Optimization Using WB-CT/MRI and Synthetic WB-CT - The AuToMI Project
Total Body Irradiation (TBI) was shown to help in providing immunosuppression that facilitates the donor transplant acceptance. Randomized trials demonstrated that conditioning regimens to bone marrow transplantation (BMT)…
- Trial name
- AuToMI (NCT04976205)
- Testing
- Total Marrow (Lymph-node) Irradiation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Clinico Humanitas
Adult Patients With Locally Advanced Rectal Cancer Indicated to Neoadjuvant Therapy and Surgery
Postoperative Complications After Neoadjuvant Chemoradiotherapy or Short-course Radiotherapy and Total Neoadjuvant Treatment: a Multicentric Retrospective Cohort Study
The primary objective of the study is to compare the rate of postoperative complications between rectal cancer patients undergoing standard neoadjuvant chemoradiotherapy or short- course radiotherapy and patients receiving TNT.
- Trial name
- POCAT (NCT07346248)
- Testing
- Chemoradiotherapy
- Where
- Italy
- Volunteers
- 266 people
- Sponsor
- Istituto Clinico Humanitas
Prostate Cancer, Bladder Cancer
DRG Mutations in Prostate Cancer: a Guiding Light for Enhanced Screening and Personalised Therapy
At the present moment, there is no international consensus on the optimal screening to perform in men with a specific genetic/molecular risk for PCa.
- Trial name
- NCT07265414
- Testing
- Screening Platform
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Istituto Clinico Humanitas
Muscle Weakness, Critical Illness
Development of the Italian Version of the ICU Mobility Scale (IMS). Cross-cultural Adaptation, Italian Translation, and Validation Study.
Early mobilisation of the patient admitted to intensive care units (ICUs) is essential to prevent Intensive Care Unit Acquired Weakness (ICUAW).
- Conditions
- Muscle Weakness, Critical Illness, Critical Illness Recovery, Acquired Weakness
- Trial name
- NCT07195942
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas
Severe Pneumonia
Lung Response to a Higher PEEP During Severe Pneumonia: a CT Study
At their institution, the investigators routinely assess the individual response of mechanically ventilated patients with acute respiratory failure to higher positive end-expiratory pressure (PEEP) by examining changes in lung…
- Trial name
- NCT07112976
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Istituto Clinico Humanitas
Cancer
Exploring Photon-Counting CT for Enhanced Target Delineation and Dose Accuracy in Personalized Radiotherapy - ANTHEM
Radiotherapy remains a cornerstone of oncology care, particularly for rare or orphan cancers and chronic oncologic and rare non oncologic conditions, where precision and individualized treatment planning are necessary.
- Trial name
- RAD4/RT_ANTHEM (NCT07098247)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Lymph Nodes
Endoscopic Ultrasound Elastography (Strain Ratio) and Fractal-based Quantitative Analysis for the Mediastinal and Abdominal Lymphadenopathies
Endoscopic ultrasound (EUS) and EUS-guided tissue acquisition (EUS-TA) are minimally invasive techniques to establish the benign or malignant nature of lymph nodes (LNs) with a very high accuracy.
- Trial name
- Lymph/EUS/01 (NCT04671784)
- Testing
- EUS-E
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Istituto Clinico Humanitas
High Risk Prostate Cancer
PRospective Observational Study of STereotactic Body rAdiation Therapy With Androgen Deprivation Therapy for Organ-confined High-risk Prostate Cancer: the PROSTAR Trial
Prostate Cancer (PCa) is the second most common malignancy and the 5th common cause of cancer-related mortality in men worldwide.
- Trial name
- PROSTAR (NCT06949254)
- Where
- 3 sites in Italy
- Volunteers
- 49 people
- Sponsor
- Istituto Clinico Humanitas
Acute Respiratory Failure, Oxygen Inhalation Therapy
External Validation of the BREF Models
Introduction High-flow oxygen therapy is increasingly used to treat acute respiratory failure (ARF). It can reduce intubation rates without increasing mortality.
- Conditions
- Acute Respiratory Failure, Oxygen Inhalation Therapy, Respiratory Distress
- Trial name
- BREF2 (NCT06669312)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Istituto Clinico Humanitas
Gastric Cancer
Artificial Intelligence to Solve the MissINg of Gastric Cancer (AIMING)
Our AIMING project comprises four core work packages (WPs): WP1. Nation-level randomized controlled trial; WP2. Development of an innovative AI tool; WP3. Novel microsimulation modelling; WP4. Patient inclusion.
- Trial name
- GAIN (NCT06971471)
- Testing
- Integration of Artificial Intelligence (AI) assistance to screening gastroscopy
- Volunteers
- 6,600 people
- Sponsor
- Istituto Clinico Humanitas
Infertility Assisted Reproductive Technology, Oocyte Retrieval
ART Cycle Outcomes When Only 1 to 3 Oocytes Are Retrieved
This is a monocentric retrospective observational study. The study focuses on the women who underwent Assisted Reproductive Technology (ART) cycles with poor ovarian response (POR), defined as <4 oocytes retrieved.
- Trial name
- POR (NCT06950476)
- Testing
- Oocyte Retrieval
- Volunteers
- 3,761 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Precancerous Lesion of Colon
Suturing Through-the-scope System Used for Prophylactic Closure of Colonic Post-ESD Defects
The goal of this study is to perform a randomized trial to compare a new through-the-scope suturing system and conventional clips for closure of defect after ESD for 30-60 mm colonic polyps.
- Trial name
- STITCH (NCT06443047)
- Testing
- TTS suturing system
- Volunteers
- 66 people
- Sponsor
- Istituto Clinico Humanitas
Osteoarthritis, Knee
Prediction AlgoriThm for regeneraTive Medicine Approach in knEe OA: New Decision-making Process Based on Patient pRofiliNg (PATTERN)
Osteoarthritis (OA) is a degenerative joint disease characterised by chronic pain, degradation and loss of articular cartilage, osteophyte formation and varying degrees of synovial inflammation.
- Trial name
- PATTERN (NCT05447767)
- Testing
- KIT BMAC, at-SVF FIDIA
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Istituto Clinico Humanitas