Clinical trials: sponsored by Johns Hopkins University
Mild Autonomous Cortisol Secretion (MACS)
Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS)
To characterize the impact of Isturisa on clinical features and comorbidities associated with MACS. The investigators hypothesize that patients treated with Isturisa will exhibit significantly better metabolic indicators (such as…
- Trial name
- NCT07247058
- Testing
- Osilodrostat (Isturisa)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Neurofibromatosis Type 1, Neurofibromatosis 1
Natural History Study of Cutaneous Neurofibromas in People With NF1
People diagnosed with NF1 may develop cutaneous neurofibromas, also known as cNFs. These benign tumors can cause discomfort and affect a person's quality of life.
- Conditions
- Neurofibromatosis Type 1, Neurofibromatosis 1, Neurofibromatosis (Nonmalignant), Cutaneous Neurofibroma
- Trial name
- cNF Natural Hx (NCT05581511)
- Testing
- Evaluation of the natural history of cutaneous neurofibromas
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Johns Hopkins University
Idiopathic Subglottic Stenosis
Adjuvant Steroid Outcomes in Idiopathic Subglottic Stenosis
This study will examine the ability of steroid injections into the site of stenosis following surgical dilation to delay the need for repeated surgical dilations.
- Trial name
- ASTRO (NCT07228104)
- Testing
- Triamcinolone 0.1%
- Where
- 10 sites in United States
- Volunteers
- 226 people
- Sponsor
- Johns Hopkins University
Pancreas Cancer, Peutz-Jeghers Syndrome (PJS)
The Cancer of the Pancreas Screening-5 CAPS5)Study
Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.
- Conditions
- Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier
- Trial name
- CAPS5 (NCT02000089)
- Testing
- Secretin, MRI, Tumor marker gene test with CA19-9
- Where
- 9 sites in United States
- Volunteers
- 9,000 people
- Sponsor
- Johns Hopkins University
Asthma
AIRWEIGHS: Investigating Obesity as a Susceptibility Factor for Air Pollution in Childhood Asthma
Background: Asthma and obesity are public health crises that have concurrently risen over the past decades, affecting millions of children in the United States and disproportionately affecting low-income minority children in…
- Trial name
- NCT02763917
- Testing
- Active Air Purifier
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Johns Hopkins University
Thyroid Cancer, Graves Disease
Personalized Treatment in Thyroid Disorders
The Collar Therapy Indicator (CoTI) (A device that is placed in collar around the neck resembling a turtle neck sweater collar with a wire and recording box) has been shown in a single small previously published experience to…
- Trial name
- NCT03517579
- Testing
- Cervical Collar Therapy Indicator (COTI)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Low Back Pain, Recurrent, Healthy
Effects of Sleep Disruption on Drug Response
The central scientific premise of the proposed study is that sleep disruption (SD) will influence individuals' subjective response to blinded medication administration.
- Trial name
- NCT03680287
- Testing
- Within-Subject test of blinded study medication
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment, Primary Progressive Aphasia
Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive Aphasia (PPA), mild…
- Conditions
- Mild Cognitive Impairment, Primary Progressive Aphasia, Dementia
- Trial name
- NCT05978804
- Testing
- Computerized Cognitive Training, Active tDCS (tDCS) on DLPFC
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Tuberculosis, Latent
Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TB
A seamless, staged Phase II/III, open-label, multicenter, non-inferiority trial, to compare the efficacy and safety of 4 weeks of bedaquiline (BDQ) versus a a standard regimen for preventing regimen for preventing confirmed or…
- Trial name
- BREACH-TB (NCT06568484)
- Testing
- Bedaquiline, Isoniazid, rifapentine, Levofloxacin
- Where
- 8 sites in Mongolia, Peru and 2 more
- Volunteers
- 2,530 people
- Sponsor
- Johns Hopkins University
HIV/AIDS, Tuberculosis
Prevent TB: Choice Architecture for TPT Delivery
Background: Clinical guidelines and policies often fail to achieve high levels of delivery of intended clinical interventions. The difference in what the investigators know works and what is actually delivered at the clinic-level…
- Trial name
- NCT04466488
- Testing
- Choice Architecture
- Where
- South Africa
- Volunteers
- 50,798 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Disturbance, Opioid-use Disorder
Examining the Role of the Orexin System in Sleep and Stress in Persons With Opioid Use Disorder
This study is designed to elucidate the role of the orexin neurotransmitter system in sleep disturbance and circadian rhythms of stress that might in turn influence relapse behaviors in persons on medication-assisted treatments…
- Trial name
- NCT04287062
- Testing
- Suvorexant
- Where
- 5 sites in United States
- Volunteers
- 249 people
- Sponsor
- Johns Hopkins University
Atopic Dermatitis
Dupilumab De-escalation in Pediatric Atopic Dermatitis
This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD)…
- Trial name
- NCT06116526
- Testing
- Dupilumab - Discontinuation, Dupilumab - Dose Reduction, Dupilumab - Standard Dose
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Hypertension (HTN), Diabetes (DM)
Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health (Healthy Heart - CKM)
The investigators are proposing a new team-based shared decision-making (SDM) program. The goal of this study is to see whether this program is practical and whether it may help adults with cardiometabolic risk factors and…
- Conditions
- Hypertension (HTN), Diabetes (DM), Hyperlipidaemia, Kidney Disease
- Trial name
- SDM in CKM (NCT07662616)
- Testing
- Team-based shared decision-making
- Volunteers
- 94 people
- Sponsor
- Johns Hopkins University
Epilepsy, Dyslipidemia
Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet
Ketogenic diet therapies (KDTs) emphasize high fat and very low carbohydrate intake and help to control seizures in adults who fail to respond to medications.
- Trial name
- NCT06369571
- Testing
- Atorvastatin 10mg, Modification of dietary fat composition
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Johns Hopkins University
Smoking Cessation, HIV
Evaluating Smoking Cessation Interventions for PWH in South Africa
The overall objective of the study is to optimize a smoking cessation treatment package for people with HIV (PWH) that can be integrated into existing HIV care in South Africa.
- Conditions
- Smoking Cessation, HIV, Comorbidities and Coexisting Conditions
- Trial name
- Tlogela (NCT05413122)
- Testing
- Varenicline, Nicotine patch, Nicotine gum
- Where
- South Africa
- Volunteers
- 660 people
- Sponsor
- Johns Hopkins University
Psilocybin Intoxication
The Impact of Dose on the Impairing, Intoxicating, and Abuse-Related Effects of Psilocybin
This study will evaluate the subjective and behavioral effects of psilocybin relative to placebo and alcohol.
- Trial name
- NCT07877987
- Testing
- 0mg Psilocybin Capsule + 0.00% BAC Alcoholic Drink, 1mg Psilocybin Capsule + 0.00% BAC Alcoholic Drink, 5mg Psilocybin Capsule + 0.00% BAC Alcoholic Drink
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use, Impaired Driving
Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance
The purpose of this research is to determine the extent to which oculomotor function accurately detects THC-impairment, if cannabis use experience impacts this detection threshold, and to examine how the oculomotor index…
- Conditions
- Cannabis Use, Impaired Driving, Cognitive Impairment
- Trial name
- NCT06351540
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Asthma, Asthma Chronic
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
- Conditions
- Asthma, Asthma Chronic, Overweight and Obesity
- Trial name
- NCT06273072
- Testing
- Metformin hydrochloride extended-release tablets
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Cannabis Intoxication
Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)
This study will evaluate the subjective and behavioral effects of cannabis products containing delta-9-tetrahydrocannabinol and cannabidiol
- Trial name
- NCT07870187
- Testing
- 0mg THC + 0mg CBD Brownie, 10mg THC + 0mg CBD Brownie, 10mg THC + 10mg CBD Brownie
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Endometriosis, Endometrial Diseases
Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance
This study will test the hypothesis that the molecular changes present in ectopic endometriosis lesions correlate with progesterone-resistant disease (using the criteria defined in this study) and are present in matched eutopic…
- Trial name
- NCT03756480
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- Johns Hopkins University
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