Clinical trials: sponsored by Johns Hopkins University
Low Back Pain
A Placebo-Controlled Study Assessing Lateral Branch Radiofrequency Denervation for Sacroiliac (SI) Joint Pain
In order to determine whether L4 and L5 primary dorsal rami and S1-3 lateral branch radiofrequency denervation is effective for sacroiliac (SI) joint pain, we are conducting a randomized, controlled study.
- Trial name
- NCT00373724
- Testing
- radiofrequency denervation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Urticaria
Effect of Anti-IgE in Chronic Urticaria
This study is being done to find out if a drug called Xolair (omalizumab), an anti-IgE antibody, is safe and effective for people with chronic urticaria (hives) with persistent symptoms in spite of taking antihistamines.
- Trial name
- NCT00130234
- Testing
- Xolair® (Omalizumab)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
High Blood Pressure
Intervention Study to Control High Blood Pressure for Korean American
The primary objective of the proposed clinical trials is to compare the differential reduction in blood pressure in underserved hypertensive adult Korean American.
- Trial name
- HBP (NCT00473681)
- Testing
- Self-Help Intervention Program-High Blood Pressure
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- Johns Hopkins University
Acute Ischemic Stroke
Induced Hypertension for Acute Ischemic Stroke
The ultimate goal of this multicenter, phase II study is to increase blood pressure until either a neurologic response is seen or a target mean arterial pressure of 30% above baseline is achieved.
- Trial name
- NCT00227448
- Testing
- intravenous saline, intravenous phenylephrine, intravenous levophed
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Systemic Lupus Erythematosus
Memantine in Systemic Lupus Erythematosus
Neuropsychiatric manifestations of Systemic Lupus Erythematosus (NPSLE) are both common and an important source of morbidity. Of the case definitions for NPSLE syndromes that have recently been developed, cognitive dysfunction…
- Trial name
- NCT00181298
- Testing
- Memantine
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Johns Hopkins University
Amyotrophic Lateral Sclerosis
Noninvasive Ventilation in ALS Patients With Mild Respiratory Involvement
Non-invasive ventilation or BiPAP®, which is a form of breathing support delivered through a facemask, is a successful treatment for the respiratory complications of amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT00386464
- Testing
- noninvasive positive pressure ventilation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Systemic Lupus Erythematosus
Lupus Atherosclerosis Prevention Study
Cardiovascular disease, specifically from atherosclerosis, is the major cause of mortality in systemic lupus erythematosus (SLE) in developed countries.
- Trial name
- NCT00120887
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Fighting Behavior, Aggression
Community-Based Violence Prevention for High-Risk Youth
Study Aims: 1) Assess the receptiveness of youth and families to injury prevention interventions initiated from the emergency department; 2) In a sample of high risk youth presenting to the ED with interpersonal assault injuries…
- Trial name
- NCT00444197
- Testing
- Mentoring and violence prevention curriculum with parental monitoring
- Where
- 2 sites in United States
- Volunteers
- 198 people
- Sponsor
- Johns Hopkins University
Delivery of Services to Rural Populations in India
Effect of Information on Service Delivery in Rural India
A lack of public awareness about entitled health and social services may contribute to poor delivery of services in developing countries. We sought to determine the impact of educating villagers about entitled services.
- Trial name
- NCT00421291
- Testing
- Education
- Where
- India
- Sponsor
- Johns Hopkins University
Clostridium Difficile
Use of Recombinant Human Lactoferrin in Long-Term Care Patients With Feeding Tubes With Clostridium Difficile.
Primary objective of this pilot study is to evaluate the effect of recombinant human lactoferrin on the rate of infection with Clostridium difficile in long-term care patients supported by enteral feeding requiring broad spectrum…
- Trial name
- NCT00377078
- Testing
- recombinant human lactoferrin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Opioid Dependence
Opioid Maintenance Medications Comparison Study
A 17 week, double-blind, randomized, parallel group, four arm design outpatient study comparing LAAM, buprenorphine and two dose levels of methadone for the treatment of opioid dependence.
- Trial name
- NCT00344812
- Testing
- LAAM. buprenorphine and methadone
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Johns Hopkins University
Mucociliary Clearance
Mucociliary Clearance in Healthy Subjects: Comparison of Levalbuterol and Racemic Albuterol
The purpose of this study is to determine whether lung mucociliary clearance (MCC) can be significantly enhanced in healthy subjects by one week of inhalation of nebulized levalbuterol aerosol, as compared to racemic albuterol or…
- Trial name
- NCT00325767
- Testing
- nebulized albuterol (2.5 mg/3ml/dose), nebulized levalbuterol (1.25 mg/3ml/dose)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Choroidal Neovascularization, Age-Related Macular Degeneration
Neovascular Age Related Macular Degeneration (AMD), Periocular Corticosteroids, and Photodynamic Therapy (PDT)
Randomized controlled clinical trial of periocular corticosteroids as adjunctive therapy to photodynamic therapy (PDT) for patients with neovascular age-related macular degeneration (AMD).
- Trial name
- NCT00305630
- Testing
- Periocular injection of triamcinolone acetonide 40mg
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome
Pilot Study of Cyclophosphamide in Patients With Life-Threatening Systemic Lupus Erythematosus or Antiphospholipid Antibody Syndrome
OBJECTIVES: I. Determine the induction of durable remission in patients with life-threatening systemic lupus erythematosus or antiphospholipid antibody syndrome treated with cyclophosphamide. II.
- Trial name
- NCT00010400
- Testing
- Cyclophosphamide, filgrastim
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University