Clinical trials: sponsored by KU Leuven
Embryo Transfer
Natural Versus Artificial Cycle for Frozen-Thawed Embryo Transfer
This study evaluates clinical pregnancy rates, obstetrical outcome parameters, costs and patient preferences in natural cycle versus artificial cycle frozen embryo transfers (FET).
- Trial name
- NAFT (NCT03642665)
- Testing
- Natural cycle, Estradiol Valerate, Micronized progesterone
- Where
- Belgium
- Volunteers
- 554 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Feeding, Human Milk
UmbrelLACT Study: Clinical Lactation Study on the Exposure to Medicines Via Human Milk
The goal of this observational study is to determine the concentration of medicines in human milk during maternal medicine intake.
- Trial name
- UmbrelLACT (NCT06042803)
- Testing
- Human milk collection, Optionally: maternal blood sample, Optionally: child blood sample
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Recurrent Implantation Failure
Preimplantation Genetic Testing for Aneuploidies in Patients With Recurrent Implantation Failure
Assessing whether Preimplantation Genetic Testing for Aneuploidy (PGT-A) can increase the ongoing pregnancy rate per transferred embryo and can decrease the time to pregnancy and miscarriage rate in patients with Recurrent…
- Trial name
- NCT03900780
- Testing
- PGT-A, Control
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Labor Stage, Second, Labor and Delivery
Visual Biofeedback Through Transperineal Ultrasound During the Expulsive Phase of Labour to Improve Maternal Childbirth Satisfaction
Childbirth is generally regarded as a positive life-changing experience. Up to 44% of women may however experience this as a traumatic event, with 3% suffering from post-traumatic stress disorder after childbirth.
- Conditions
- Labor Stage, Second, Labor and Delivery, Satisfaction With Care, Childbirth
- Trial name
- RCT:VB-TPU (NCT06847308)
- Testing
- visual biofeedback through trans-perineal ultrasound
- Where
- Belgium
- Volunteers
- 488 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Overweight and Obesity, Bariatric Surgery
Sarcopenia After Bariatric Surgery in Older Patients: a Cohort Study
The retrospective cohort study will compare the prevalence of sarcopenia and associated factors between older patients who have undergone bariatric surgery and older patients with obesity without previous bariatric surgery.
- Conditions
- Overweight and Obesity, Bariatric Surgery, Aging, Sarcopenic Obesity
- Trial name
- SABO (NCT05582668)
- Testing
- Bariatric surgery
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson Disease, Freezing of Gait
Investigating the Neural Signature of Freezing of Gait in Parkinson's Disease
Freezing of Gait (FOG) is a disabling symptom of Parkinson's disease (PD) and a leading cause for falls. Current medical management is inadequate to alleviate FOG so there is need for improved treatments.
- Conditions
- Parkinson Disease, Freezing of Gait, Basal Ganglia Diseases, Brain Disease
- Trial name
- FOG-EEG (NCT06841718)
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- KU Leuven
Functional Dyspepsia
Budesonide as a Treatment for Functional Dyspepsia
This clinical study is being conducted to evaluate the investigational drug, Budesonide, for the treatment of functional dyspepsia.
- Trial name
- BuDy (NCT06841406)
- Testing
- budesonide, Mannitol
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Carpal Tunnel Syndrome
Assessment of Subsynovial Connective Tissue Thickness in Carpal Tunnel Syndrome
The general aim of this research is to gain insight in the role of SSCT in the etiology and progression of CTS. We hypothesize that (degenerative) damage of the SSCT occurs early on in the pathogenesis of CTS.
- Trial name
- NCT04491058
- Testing
- SSCT thickness measurement
- Where
- Belgium
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Flatfoot, Flexible
The Effect of Foot Core Exercises or Foot Orthotics in Symptomatic Flexible Flatfoot
The overall goal of this study is to evaluate the effect of a foot strengthening program (focused on the intrinsic foot muscles) on ankle and foot joint kinematics and kinetics (rearfoot, midfoot, and forefoot) in patients with…
- Trial name
- NCT05840965
- Testing
- Foot muscle strengthening, Foot orthotics
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Cutaneous Malignant Melanoma
Vitamin D Supplementation in Cutaneous Malignant Melanoma Outcome
To assess whether vitamin D supplementation after surgery of a first cutaneous malignant melanoma protects against relapse of the disease.
- Trial name
- ViDMe (NCT01748448)
- Testing
- Vitamin D
- Where
- 4 sites in Belgium, Hungary
- Volunteers
- 436 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hypertension
Hypertension, Ethnicity and Exercise Trial
The main aim of this study is to investigate the acute effects of a single bout of isometric handgrip exercise (IHG) and a single bout of aerobic endurance exercise (AEX) on blood pressure, both immediately after exercise and…
- Trial name
- HYPE2X (NCT06824805)
- Testing
- Exercise
- Where
- Suriname
- Volunteers
- 60 people
- Sponsor
- KU Leuven
Cognitive Aging
Elucidating How Physical Activity and Sleep Relate to Optimal Cognitive Ageing
Increased longevity is one of the greatest success stories in public health. However, ageing is accompanied by cognitive decline which affects people's daily functioning and, if it develops to dementia, their ability to live…
- Trial name
- PASOCA (NCT05455229)
- Where
- Belgium
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Oesophageal Cancer, Gastric Cancer
Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types
The aim of the project is to demonstrate superior detection ratio of [18F]AlF-FAPI-74 PET/CT compared to [18F]FDG PET/CT or conventional imaging in treatment-naïve, newly diagnosed patients with oesophagogastric adenocarcinoma…
- Conditions
- Oesophageal Cancer, Gastric Cancer, Pancreatic Ductal Adenocarcinoma, FAP
- Trial name
- FAPIDO (NCT06782412)
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- 3 sites in Belgium
- Volunteers
- 109 people
- Sponsor
- KU Leuven
Heartburn, Dyspepsia
Primary carE PPi dEprescRibing Trial
Proton pump inibitors (PPIs) is a class of medications that reduce the acid secretion in the stomach. These medications are very effective to relieve symptoms of acid reflux for a well-identified group of diseases and conditions.
- Conditions
- Heartburn, Dyspepsia, Reflux
- Trial name
- PEPPER (NCT05629143)
- Testing
- de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate
- Where
- Belgium
- Volunteers
- 724 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer, Lymphedema
Who and Why do Patients Report Lymphedema After Breast Cancer Treatment Without an Objective Measurable Swelling
Breast cancer related lymphedema (BCRL) at the arm and/or trunk is an extremely dreaded complication after breast cancer treatment due to its chronicity and impact.
- Conditions
- Breast Cancer, Lymphedema, Sensory Processing Disorder
- Trial name
- LymphSens (NCT06324721)
- Testing
- Measurements for breast cancer related lymphedema (volumetric measurements, bioimpedance spectroscopy, bioimpedance analysis, tissue dielectric constant measurements, ultrasonography), Measurements for lymphatic problems (volumetric measurements, tissue dielectric measurement, lymphofluoroscopy), Measurements for sensory processing problems by monofilaments, algometer, goniometer, and neurosensory analyzer
- Where
- Belgium
- Volunteers
- 230 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functional Dyspepsia
Neuro-immune Interactions and PPI
Prospective interventional study on duodenal neuro-immune interactions in healthy volunteers and functional dyspepsia patients and the effects of PPI
- Trial name
- NCT04713969
- Testing
- Pantoprazole 40mg
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphedema of Upper Arm, Breast Cancer
Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema
Breast-cancer related lymphoedema (BCRL) is a common phenomenon. Early diagnosis and treatment is very important to alter the normal progression of this disease.
- Conditions
- Lymphedema of Upper Arm, Breast Cancer, Diagnoses Disease
- Trial name
- DEARLY (NCT03210311)
- Testing
- compression
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Covid19, Eye Diseases
Tear Film SARS-nCoV-2 Detection in Symptomatic and Pauci-symptomatic Patients.
To investigate the presence of SARS-nCoV-2 in the tear film of symptomatic and pauci-symptomatic SARS-nCoV-2 positive patients.
- Trial name
- Eye-Covid (NCT04799704)
- Testing
- swabbing of conjunctiva
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson Disease
Learning Potential of Patients With Parkinson's Disease After Two Weeks of Targeted Touchscreen Training
Parkinson's disease (PD) is characterized by severe motor and non-motor symptoms, including upper limb dysfunction. Due to the degradation of dopaminergic neurons in the striatum, PD patients experience difficulties with motor…
- Trial name
- NCT05696197
- Testing
- Targeted touchscreen training
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- KU Leuven
Osteoarthitis, Fibromyalgia
Screening Anxiety and Depression Among Patients with Chronic Musculoskeletal Pain Within Physiotherapy Practices
This study will investigate whether physiotherapists can accurately identify symptoms of anxiety and of depression in patients with chronic musculoskeletal pain (primary aim).
- Conditions
- Osteoarthitis, Fibromyalgia, Rheumatoid Arthritis (RA, Low Back Pain
- Trial name
- NCT06785883
- Where
- Belgium
- Volunteers
- 750 people
- Sponsor
- KU Leuven
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