Clinical trials: sponsored by KU Leuven
Vault Prolapse, Vaginal
An Institutional Audit of the Short Term Complications and Long Term Outcomes of Patients Undergoing Laparoscopic Sacrocolpopexy for Vault/cervical Prolapse.
An institutional audit of the short term complications and long term outcomes of patients undergoing laparoscopic sacrocolpopexy for vault/cervical prolapse.
- Trial name
- NCT04378400
- Testing
- Sacrocolpopexy
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Duchenne Muscular Dystrophy (DMD)
Follow-up of NIV At Home in Patients with Duchenne Muscular Dystrophy
The aim of this study is to verify whether full video home polysomnography (sleep study) with nocturnal transcutaneous CO2 monitoring is feasible in the follow-up of non-invasive ventilation (NIV) in patients with Duchenne…
- Trial name
- NCT06773988
- Testing
- Monitoring of NIV at home
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 2 Diabetes
Comparison of Diabetes Patients - Care Trajectory Versus Convention
In Belgium, various structures and reimbursement programs are in place for managing Type 2 Diabetes Mellitus (T2DM). The Diabetes Care Trajectory is primarily utilized for patients who require a maximum of two insulin injections…
- Trial name
- NCT06577584
- Testing
- Follow-up in the Diabetes Care Trajectory, Follow-up in the Diabetes Convention
- Volunteers
- 20,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetes Mellitus, Type 1
MELD-ATG: Phase II, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D)
This study has been set up within the framework of the INNODIA network. INNODIA is a global partnership between 31 academic institutions, 6 industrial partners, a small sized enterprise and 2 patient organizations, bringing their…
- Trial name
- Meld-ATG (NCT04509791)
- Testing
- Anti-Human Thymocyte Immunoglobulin, Rabbit
- Where
- 14 sites in Austria, Belgium and 6 more
- Volunteers
- 114 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Status Epilepticus, Ictal-interictal Continuum
The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
The investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (NCSE). The investigators will obtain three functional images of the brain: 1.
- Conditions
- Status Epilepticus, Ictal-interictal Continuum, Positron-emission Tomography, Perfusion Weighted MRI
- Trial name
- NCT06017973
- Testing
- MRI scan including arterial spin labelling of the brain, CT perfusion scan of the brain, FDG-PET scan of the brain
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ocular Surface Microbiome
Confounding Factors in Ocular Surface Microbiome Research
To elucidate confounding factors in ocular surface microbiome research and to confirm the presence of a core ocular surface microbiome and its temporal stability.
- Trial name
- CoFa (NCT04193917)
- Testing
- Conjunctival swab
- Where
- Belgium
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Volunteers, Stress
Effects of Rifaximin on Gut Microbiota and Emotion
A randomized, triple-blind, placebo-controlled study on the effect of rifaximin on psychobiological functions in healthy men.
- Conditions
- Healthy Volunteers, Stress, Fear
- Trial name
- NCT05587036
- Testing
- Rifaximin
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pain
The Use of QST to Characterize Somatosensory Functionality
Pain has a significant impact on quality of life and poses an enormous burden on the healthcare system. The subjective nature of pain complicates its mapping and treatment.
- Trial name
- NCT06439004
- Testing
- Quantitative Sensory Testing
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glaucoma
Astigmatism Post-trabeculectomy
The aim of this project: 1. Confirming the modification in corneal astigmatism after trabeculectomy with MMC and intracameral administration of bevacizumab. 2. Medium-term follow up (6 months) of the induced corneal astigmatism.
- Trial name
- NCT01711190
- Testing
- trabeculectomy
- Where
- Belgium
- Volunteers
- 52 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Shoulder Pain, Anesthesia
The Effect of Deep Neuromuscular Block and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity in Shoulder Surgery Using a Deltopectoral Approach
The study evaluates wether deep neuromuscular block during entire surgical procedure to the gleno-humeral joint or the proximal humerus using a deltoideo-pectoral approach results in less muscular damage to the deltoid muscle and…
- Trial name
- NCT03643913
- Testing
- Deep neuromuscular block, Moderate neuromuscular block, Neuromuscular Blocking Agents and reversing agents
- Where
- Belgium
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Crohn Disease, Colitis, Ulcerative
Remote Monitoring of Patients With an Inflammatory Bowel Disease Under no or Maintenance Therapy
Routine follow-up of patients with inflammatory bowel disease (IBD) under stable doses of maintenance therapy or no IBD-related therapy at all, consists of intensive monitoring with prescheduled outpatient visits every six or…
- Conditions
- Crohn Disease, Colitis, Ulcerative, Inflammatory Bowel Diseases
- Trial name
- ROADMAP (NCT06338930)
- Testing
- Remote monitoring
- Volunteers
- 456 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inflammatory Bowel Diseases, Psoriasis
Response to Ustekinumab for Anti-tnf Induced Psoriasiform Skin Lesions
Using transcriptomics and proteomics to gain insights in the development of psoriasiform skin lesions under anti-tumor necrosis factor (TNF) therapy, and predicting response to ustekinumab.
- Trial name
- STRAUSS (NCT03629379)
- Testing
- Ustekinumab, Vedolizumab
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pouchitis
Stelara fOr ChRonic AntibioTic rEfractory pouchitiS
To evaluate the efficacy and safety of ustekinumab in the treatment of chronic antibiotic refractory and relapsing pouchitis.
- Trial name
- SOCRATES (NCT04089345)
- Testing
- Ustekinumab
- Where
- 3 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inflammatory Bowel Diseases
Model-informed Dose De-escalation of Infliximab in Patients With Inflammatory Bowel Diseases
This is a monocentric, two-arm, non-randomised, non-blinded, historically controlled, interventional trial. The purpose of this trial is to investigate the effect of model-informed infliximab dose de-escalation on the infliximab…
- Trial name
- MODIFI (NCT04982172)
- Testing
- Infliximab
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type1 Diabetes
Closed-loop Insulin Delivery in Pregnant Women With Type 1 Diabetes
Multi-centric open-label randomized controlled trial (RCT) with 11 Belgian centers and one Dutch center in pregnant women with type 1 diabetes to assess safety, efficacy, feasibility and cost-effectiveness of 780 MiniMed…
- Trial name
- CRISTAL (NCT04520971)
- Testing
- 780G, standard of care
- Where
- 12 sites in Belgium, Netherlands
- Volunteers
- 95 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dysphagia Following Cerebrovascular Accident, Dysphagia
The Effect of Pharyngeal Electrical Stimulation on Peripheral Biomechanical Aspects of Deglutition
The goal of this clinical trial is to clarify which biomechanical aspects of swallowing are altered by Pharyngeal Electrical Stimulation (PES) in stroke patients, ICU patients and healthy volunteers.
- Trial name
- PES (NCT05666141)
- Testing
- Pharyngeal Electrical Stimulation
- Where
- Belgium
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endometriosis Ovary, Endometrioma
Conservative Endometrioma Surgery
To study which surgical technique offers better results in treating endometriomas in terms of ovarian reserve preservation. The 2 conservatives techniques used are: 1. The combined technique 2.
- Trial name
- BLAST (NCT04151433)
- Testing
- Comparison between 2 different laparoscopic techniques in conservative surgical treatment of endometriomas (both arms are existing and accepted surgical strategies).
- Where
- 4 sites in Belgium
- Volunteers
- 92 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gynecologic Disease, Endometriosis
Ultrasound Evaluation of the Pelvis in Women with Suspected Endometriosis Scheduled for Laparoscopic Surgery
An international multicenter observation study to evaluate the diagnostic accuracy and predictive value of ultrasound using the IDEA terminology in the detection of deep endometriosis in women scheduled for surgery.
- Conditions
- Gynecologic Disease, Endometriosis, Endometriosis, Rectum, Endometriosis of Colon
- Trial name
- IDEA1 (NCT04171297)
- Testing
- Ultrasound evaluation of DE
- Where
- 3 sites in Australia, Belgium and 1 more
- Volunteers
- 1,866 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Major Depressive Disorder
Blended Care Versus Face-to-Face Therapy for Depression
Depression is a severe mental disorder that affects 5-7% of Belgians each year. Unfortunately, many individuals with depression do not seek professional help, and if they do seek professional help, waiting lists for psychotherapy…
- Trial name
- BLENDED (NCT04337242)
- Testing
- B-DIT, B-CBT, DIT
- Where
- 6 sites in Belgium
- Volunteers
- 504 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Neoplasm, Pain
Effectiveness of a Modern Educational Intervention in Breast Cancer Patients
In addition to fatigue, pain is the most frequent and persistent symptom following breast cancer and breast cancer treatment. Despite the effectiveness of different physical therapy modalities, such as manual techniques, passive…
- Trial name
- EduCan (NCT03351075)
- Testing
- Standard physical therapy program, Modern educational program, Traditional biomedical educational program
- Where
- Belgium
- Volunteers
- 184 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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