Clinical trials: sponsored by KU Leuven
Deafness Unilateral
Cochlear Implantation for Young Single-sided Deaf Children
Children with profound sensorineural unilateral hearing loss (UHL) lag behind in spoken language, cognition, spatial hearing, and academic performance compared to normal hearing (NH) children.
- Trial name
- CICADE (NCT04738968)
- Testing
- Cochlear implant
- Where
- 4 sites in Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
FOod Additives on the Mucosal Barrier
This is a 6-week pilot study in 60 healthy volunteers to explore (1) the effect of an emulsifier-free diet (2) the effect of three dietary emulsifiers which are believed to detrimentally affect human health, (3) and the effect of…
- Trial name
- FOAM (NCT06552156)
- Testing
- Dietary Emulsifier
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Geriatrics, Medical Oncology
Geriatric and Oncological Evaluation With Technology for Holistic Healthcare Management for Older Multimorbid Patients.
The GerOnTe TWOBE study aims to evaluate the effectiveness of the GerOnTe intervention, consisting of a renewed, patient-centred, care pathway coordinated by an APN and supported by a Health Professional Consortium and IC…
- Conditions
- Geriatrics, Medical Oncology, Critical Pathways, Digital Technology
- Trial name
- GerOnTe-TWOBE (NCT05423808)
- Testing
- Health Professional Consortium, Holis Dashboard - Holis Patient App
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
Study on Treating by Eating: Role of AGEs on Mucosal Barrier and Microbiome.
This is an exploratory study aimed at healthy volunteers to investigate the impact of differential cooking methods on global and gut inflammation, intestinal permeability, and the gut microbiota.
- Trial name
- STEAMM (NCT06547190)
- Testing
- High AGEs diet, Low AGEs diet
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stress, Healthy Volunteers
Brain Responses to Short-Chain Fatty Acid Intervention
A randomized, triple-blind, placebo-controlled study on the effect of colon-delivered short-chain fatty acids (SCFAs) on neural responses to stress and neuroepigenetics.
- Trial name
- MoodBugs HDAC (NCT06546683)
- Testing
- Short-Chain Fatty Acids
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hearing Disability
Training Listening Skills With the Inclusion of Cognitive Control
Participating in spoken conversation constitutes a multitasking situation with concurrent demands on sensorimotor (auditory, postural) and cognitive functioning (memory, updating, task switching and inhibition).
- Trial name
- TRAILS (NCT05766020)
- Testing
- Listen training
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer
A Phase IV Study to Collect Data on the Efficacy and Safety of RIBociclib in Older Women With Breastcancer
The RibOB study is a prospective, open lable, single arm trial which will evaluate the clinical efficacy, overall safety and tolerability of ribociclib in combination with letrozole in older women (≥70 years) with HR+/HER2- aBC…
- Trial name
- RibOB (NCT03956654)
- Testing
- Ribociclib
- Where
- Belgium
- Volunteers
- 78 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Oral Health, Old Age; Dementia
Evaluation of the Use of a Novel Oral Health Screening Instrument by Caregivers in Nursing Homes
BACKGROUND: Oral health of nursing home residents is often poor. Oral health is related to general health, quality of life and well-being.
- Conditions
- Oral Health, Old Age; Dementia, Long-Term Care, Nursing Homes
- Trial name
- OHS-interRAI (NCT06536322)
- Testing
- OHS-interRAI
- Where
- Belgium
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Tooth Extraction
Tranexamic Acid To Reduce Bleeding in Patients Treated With New Oral Anticoagulants Undergoing Dental Extraction
In patients treated with direct oral anticoagulants, bleeding events during or after tooth extraction can lead to unscheduled interruption of the antithrombotic treatment and a potential increased risk of thrombo-embolic events.
- Trial name
- EXTRACT-NOAC (NCT03413891)
- Testing
- Tranexamic Acid
- Where
- Belgium
- Volunteers
- 222 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adverse Reaction to Drug, Neonatal Disorder
Exploratory Propofol Dose Finding Study In Neonates
The aim of the study is to explore the optimal propofol dose in neonates receiving a single intravenous propofol bolus for endotracheal intubation during (semi-)elective INSURE (intubation-surfactant-extubation) procedure…
- Trial name
- NEOPROP (NCT01621373)
- Testing
- propofol administration
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cell Transplantation, Allogeneic
Belgian Cross-sectional Allogeneic Transplant Survivor Study
With the increasing successful use of allogeneic hematopoietic stem cell transplantation (HSCT) to cure advanced hematological disease, it becomes essential to evaluate the long-term effects of such a drastic treatment.
- Trial name
- BE-C@TS (NCT02312830)
- Volunteers
- 400 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open Angle Glaucoma
Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients
Glaucoma is an optic neuropathy in which the main risk factor is intraocular pressure (IOP). The search for other variables involved in glaucoma pathogenesis and progression has identified both systemic and ocular signs of…
- Trial name
- NCT02053298
- Testing
- Timolol & Dorzolamide
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dental Care for Disabled
Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability
The study aims to compare procedural sedation protocols, specifically applied for the delivery of regular dental care in persons with a mental disability.
- Trial name
- OptiSeDent (NCT02078336)
- Testing
- Midazolam Mylan, Lorazepam Mylan, Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hypotonia-Cystinuria Syndrome, Muscle Hypotonia
PREPL in Health and Disease
Evaluation of PREPL activity in healthy controls and known or possible PREPL deficient patients
- Conditions
- Hypotonia-Cystinuria Syndrome, Muscle Hypotonia, Healthy Volunteers, Dwarfism, Growth Hormone Deficiency
- Trial name
- PHD (NCT02263781)
- Testing
- Blood draw, muscle biopsy
- Where
- Belgium
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
DNA Methylation
Comparison of the Methylation Pattern of DNA in Buccal Swabs From Different Time Points
A buccal swab will be taken using a cotton stick by rubbing it against the buccal mucosa. Samples will be taken from the same participant at different timepoints.
- Trial name
- NCT02297009
- Testing
- Buccal swab
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Organ Transplantation, Intestine
Leuven Tolerogenic Protocol for Intestinal Transplantation
An immunomodulatory protocol, experimentally-proven to promote T-regulatory dependent graft protective mechanisms was applied in a clinical cohort of 13 intestinal transplant recipients to activate - in a protolerogenic…
- Trial name
- LP (NCT02314949)
- Testing
- intestinal transplantation
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Specific Polysaccharide Antibody Deficiency
Polysaccharide Antibody Response Study
Specific polysaccharide antibody deficiency (SPAD) is a primary immunodeficiency characterized by a deficient antibody production to capsular polysaccharides with normal total immunoglobulin levels.
- Trial name
- PARS (NCT02429531)
- Testing
- Pneumovax 23 (Sanofi Pasteur MSD), Typhim Vi (Sanofi Pasteur MSD)
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ovarian Failure
MAR With Artificial Gametes: Treatment Characteristics and Their Trade-offs Determining Treatment Preference
To gain insight by means of a discrete choice experiment questionnaire into characteristics of medically assisted reproduction (MAR) with artificial gametes (AGs) valued by couples confronted with ovarian failure and their…
- Trial name
- NCT02280681
- Testing
- No intervention, only questionnaire
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atopic Dermatitis
Treatment of AD With IgE Specific Immunoadsorption (IGEIAAD)
Removal of IgE through adsorption of IgE on a specially designed column after apheresis of blood has the potential to improve the severity of atopic dermatitis.
- Trial name
- IGEIAAD (NCT02365246)
- Testing
- immunoadsorptions with an IgE-specific adsorption column
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Pharmacokinetics of Posaconazole in Allogeneic Transplant Patients With Mucositis
The goal of this study is to calculate pharmacokinetic parameters and to evaluate the trough levels of posaconazole reached in patients with different stages of mucositis, due to chemotherapy and total body irradiation.
- Trial name
- NCT01420562
- Testing
- blood sampling
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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