Clinical trials: sponsored by KU Leuven
HFpEF
Accelerated Pacing and Cardiac Filling Pressures During Exercise in Patients With Heart Failure With Preserved Ejection Fraction
What is HFpEF? In heart failure with preserved ejection fraction (HFpEF), the heart pumps well but struggles to relax and fill with blood between beats.
- Trial name
- APAVE (NCT07270536)
- Testing
- Accelerated pacing with AV-delay optimization during rest and light intensity cycling
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Portal Hypertension Related to Cirrhosis
EUS-guided Response Assessment to NSBB
The goal of this clinical trial is to learn if endoscopic ultrasound (EUS)-guided portal pressure measurement can determine the treatment response to non-selective beta-blockers (NSBB) in patients with cirrhosis and clinically…
- Trial name
- NCT06513195
- Testing
- endoscopic ultrasound-guided portal pressure measurement
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hepatocellular Carcinoma (HCC)
Improving the Use of Immunotherapy to Treat Liver Cancer
This project targets patients with a form of primary liver cancer, specifically "hepatocellular carcinoma". This disease often develops in the context of a chronically diseased liver, caused by viral infections, excessive alcohol…
- Trial name
- IO-MARC (NCT07623265)
- Testing
- Blood and tissue sample
- Where
- 4 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Achilles Tendinopathy (AT)
Effect of Foot Position During Rehabilitation of Achilles Tendinopathy on Tendon Mechanics and Symptoms.
This study will investigate whether a 12-week load-based exercise program performed with an externally rotated foot position ("toes-out") leads to different changes in intra-tendinous sliding, symptoms, and function compared to a…
- Trial name
- NCT07623408
- Testing
- 12-week adaptive, load-based exercise therapy protocol for Achilles Tendinopathy
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- KU Leuven
Cerebral Palsy (CP), Typically Developing Children
Interaction Between Spasticity and the Initial Response After Balance Perturbations in Children With Spastic Cerebral Palsy
The aim of this study was to investigate the link between spasticity and the initial response after standing balance perturbations in children with spastic cerebral palsy.
- Trial name
- NCT07616193
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Cancer
Liquid Biopsies in Esophageal Cancer
Purpose of this study is to determine the value of liquid biopsies, e.g. testing of minimal residual disease (MRD) by using liquid biopsies to measure circulating tumour DNA (ctDNA) at diagnosis and during the multimodal and…
- Trial name
- NCT05704530
- Testing
- Blood sample
- Where
- 4 sites in Belgium
- Volunteers
- 248 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Obstructive Pulmonary Diseases, COPD
Effect of IMT in Patients After Acute Exacerbations of COPD
The goal of this clinical trial is to test whether home-based inspiratory muscle training can reduce hospital readmissions and death in patients recovering from a severe acute exacerbation of chronic obstructive pulmonary disease…
- Conditions
- Chronic Obstructive Pulmonary Diseases, COPD, Symptom Exacerbation
- Trial name
- IN-SPIRED (NCT07213128)
- Testing
- Training
- Where
- 12 sites in Belgium
- Volunteers
- 358 people
- Sponsor
- KU Leuven
Hip Fracture, Stroke
Implementation of the MOX Activity Monitor in Hospitalized Geriatric Rehabilitation
Staying active is essential for healthy aging, but hospitalized older adults in rehabilitation often move very little. This study explores how much physical activity these patients actually get and how it relates to their…
- Conditions
- Hip Fracture, Stroke, Fraility
- Trial name
- NCT07124247
- Testing
- Activity registration for one week with an activity monitor (MOX1)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- KU Leuven
Diabetes Mellitus, Type 1
The Impact of Hybrid Closed-loop Insulin Delivery in Type 1 Diabetes on Glycemic Control and PROMs
Since February 2019 the first hybrid closed-loop insulin pump, the Medtronic MiniMed 670G system, has been offered to people with type 1 diabetes in Belgium.
- Trial name
- INRANGE (NCT04414280)
- Testing
- Medtronic MiniMed 670G, Medtronic MiniMed 780G, Tandem Control-IQ
- Where
- 38 sites in Belgium
- Volunteers
- 1,600 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stage I Ovarian Cancer, Borderline Ovarian Tumors
A Prospective Multicenter Diagnostic Biomarker Study to Discriminate Borderline From Stage I Invasive Ovarian Cancer
The study aims to improve the diagnosis of ovarian cancer by distinguishing between borderline ovarian tumors (BOT) and stage I invasive ovarian cancer.
- Trial name
- BIOC (NCT06709872)
- Where
- 4 sites in Belgium, Czechia and 1 more
- Volunteers
- 400 people
- Sponsor
- KU Leuven
Management, Low Risk
CARES : Customized Aftercare Report for Evaluated Skin Cancer Patients
Current clinical practices often provide general verbal advice to low-risk patients, which may not sufficiently address individual concerns or offer actionable steps.
- Conditions
- Management, Low Risk, Skin Cancer
- Trial name
- CARES (NCT07330323)
- Testing
- Verbal information only, Personalized Discharge Letter, Personalized Discharge Letter + IntelliStudio
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Neoplasms
FATLAS: Comprehensive Multi-level Characterization of Systemic and Mammary Adiposity in Breast Cancer Patients.
FATLAS is a prospective, interventional, non Investigational Medicinal Product (IMP) study aiming to characterize the micro- and macroenvironment of breast cancer according to patient adiposity in different histological and…
- Trial name
- FATLAS (NCT04200768)
- Testing
- Prospective data and sample collection
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Low Grade Glioma of Brain
HyperSpectral Imaging in Low Grade Glioma
Low grade glioma (LGG) is a slowly evolving, highly invasive intrinsic brain tumor displaying only subtle tissue differences with the normal surrounding brain, hampering the attempts to visually discriminate tumor from normal…
- Trial name
- HSI-LGG-2019 (NCT04859725)
- Testing
- Hyperspectral Imaging with Snapscan camera
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alveolar Bone Resorption
LPRF Block vs. DBBM in Horizontal Bone Reconstruction
split-mouth RCT. 12 patients. horizontal GBR performed. 2 grafts were compared: test was LPRF block, control was 50% autogenous bone and 50% DBBM. 25 months follow-up.
- Trial name
- NCT07584629
- Testing
- guided bone regeneration
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson Disease, Idiopathic, Freezing of Gait
AID-FOG: Artificial Intelligence-Driven Freezing of Gait Detection in the Home
Freezing of gait (FOG) is a debilitating symptom of Parkinson's disease increases the risk of falling. Despite being a common symptom, it is still difficult to evaluate freezing of gait quickly and accurately.
- Conditions
- Parkinson Disease, Idiopathic, Freezing of Gait, Validation, Wearable Sensors
- Trial name
- AID-FOG (NCT07580612)
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Enhanced Recovery After Surgery, Cardiac Surgical Procedures
Audit of the Revised PACU Centric ERACS Program
A previous audit (S63843) found an association between improved compliance with these interventions and postoperative outcomes (hospital length of stay (LOS) and presence of ≥1 postoperative complication).
- Trial name
- ERACS2 (NCT06257745)
- Testing
- Compliance with ERACS guideline as described in the current ERACS guidelines from Engelman et al. 2019
- Where
- Belgium
- Volunteers
- 487 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke, Healthy Adult
Effects of a Robot-based Sensorimotor Upper Limb Rehabilitation Paradigm in Chronic Stroke
Sensorimotor function of the upper limb is commonly impaired after stroke, even in the chronic phase (>6 months post-stroke). Nevertheless, good sensorimotor function is needed for daily life functioning.
- Trial name
- RCT ROBUST (NCT07547800)
- Testing
- ROBUST, Kinarm therapy
- Where
- Belgium
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Spastic Cerebral Palsy
Homebased (6-week) Stretching Intervention in Children With Spastic Cerebral Palsy
This study will investigate the effect of a 6-week stretching intervention, consisting of a combination of a 2-week casting period and a home-based stretching program of the plantar flexors and hamstrings, on muscle and tendon…
- Trial name
- NCT04904094
- Testing
- Casting of the lower limb and homebased stretching exercise program.
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Disease
Nodular Shrinking in Dupuytren Disease
Dupuytren disease (DD) is a common hand disorder with disabling finger contractures that may require surgery to restore function.
- Trial name
- Echo (NCT06321991)
- Testing
- Ultrasound measurement
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Depression
Changing Tactics? Optimizing ECT in Difficult-to-treat Depression
The goal of this randomized controlled trial is to address which treatment strategy (continue right unilateral (RUL) ECT or switch to bitemporal (BT) ECT speeds up recovery and has the least impact on memory function, in case of…
- Trial name
- ChaT (NCT05923801)
- Testing
- switch to BT electrode position, continue with RUL electrode position
- Where
- Belgium
- Volunteers
- 196 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.