Clinical trials: sponsored by KU Leuven
Dysplasia in Longstanding Achalasia, Relation Between Food Stasis and Dysplasia
Achalasia and Dysplasia
Patient with achalasia have a 10-50 fold increased risk to develop esophageal squamous cell carcinoma (ESCC). Early diagnosis of ESCC is essential, and detection of an earlier dysplastic stage is preferred.
- Trial name
- NCT02010983
- Testing
- chromoendoscopy
- Where
- Belgium
- Volunteers
- 39 people
- Sponsor
- KU Leuven
Irritable Bowel Syndrome
Dose-dependent FODMAP Reintroduction in IBS
The aim of this study is to evaluate whether symptom recurrence, after successful FODMAP elimination, is dose-dependent in patients with IBS.
- Trial name
- DORI (NCT05808023)
- Testing
- FODMAP powder reintroduction
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroesophageal Cancer
Perioperative Zanidatamab and Chemotherapy for HER2 Positive Gastroesophageal Cancer
The HER-OIC clinical trial is a Phase 1b/2a study investigating a new combination of treatments for patients with HER2-positive gastroesophageal cancer.
- Trial name
- HER-OIC (NCT07477444)
- Testing
- Zanidatamab Combined with Chemotherapy
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IBS, Healthy
Measuring Nerve Activity in Small Human Intestinal Biopsies in IBS (Irritable Bowel Syndrome)
Rectal biopsies from IBS patients or healthy subjects will be taken. Biopsies will be used for: 1. the isolation of submucosal plexus to perform: 1.1 live nerve recordings and Calcium imaging; 1.2 immunohistochemistry; 1.3 mRNA…
- Trial name
- NCT01912313
- Testing
- Rectal biopsies from IBS patients or healthy subjects will be taken during proctoscopy
- Where
- Belgium
- Volunteers
- 99,999,999 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Postoperative Ileus
Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway
Hypothesis: Prucalopride can mimic electrical stimulation of the abdominal vagus nerve and has an anti-inflammatory effect. Aims: In the present pilot study, the investigators want to evaluate the anti-inflammatory effect of…
- Trial name
- NCT02425774
- Testing
- Vagus stimulation, Prucalopride
- Where
- Belgium
- Volunteers
- 31 people
- Sponsor
- KU Leuven
Irritable Bowel Syndrome
Efficacy of the DOMINO Diet App in IBS
The aim of this study is to evaluate whether the DOMINO diet application is an effective tool in the treatment of Irritable bowel syndrome in tertiary care.
- Trial name
- EDDI (NCT05808036)
- Testing
- Dietary intervention: DOMINO app, Dietary intervention: low FODMAP diet
- Where
- Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke
Potential Effects of Novel Sensorimotor Upper Limb Rehabilitation Paradigm
Sensorimotor function of the upper limb is often impaired after stroke, even in the chronic phase (minimum 6 months after stroke).
- Trial name
- NCT06870682
- Testing
- ROBUST
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- KU Leuven
Stroke
Aha BOOST Arm-hand BOOST Therapy to Enhance Recovery After Stroke: Clinical, Health Economic and Process Evaluation
The overall aim of this study is to establish the clinical- and cost-effectiveness of the arm-hand BOOST therapy when delivered on top of the usual care program in the sub-acute phase post stroke and to perform a process…
- Trial name
- AHA-BOOST (NCT06517251)
- Testing
- Arm-hand BOOST, Lower limb BOOST
- Where
- 2 sites in Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Falls Prevention, Implementation
Implementation of a Multifactorial Falls Prevention Intervention in Older Community-dWElling peRsons
Approximately 24 to 40% community-dwelling older persons fall annually, of which 21 to 45% fall recurrently. Many factors contribute to the risk of falling, such as mobility impairment, medication use, environmental issues and…
- Conditions
- Falls Prevention, Implementation, Older People
- Trial name
- BE-EMPOWERed (NCT06105437)
- Testing
- BE-EMPOWERed program
- Where
- Belgium
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Weaning Failure
Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU
Mechanical ventilation is a life-saving treatment frequently applied in intensive care unit (ICU). Nonetheless, by putting at rest the respiratory muscles, it can lead to respiratory muscle weakness and atrophy, which are…
- Trial name
- TrainToWean (NCT04658498)
- Testing
- Procedure: Usual Care (UC), Procedure: UC + HI-IMT
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- KU Leuven
Intensive Care Unit Acquired Weakness, Critical Illness
Locomotor Muscle Oxygenation and Activation During Acute Interval Compared to Constant-load Bed-cycling Exercise
Up to 60% of patients admitted to the Intensive Care Unit (ICU) with a prolonged stay in the ICU develop complications such as intensive care unit acquired weakness (ICUAW) characterized by limb and respiratory muscle weakness.
- Trial name
- NCT05279547
- Testing
- Constant-load bed-cycling exercise, Interval bed-cycling exercise
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Intra-bony Pockets, Periodontitis
Biologicals in Management of Intra-Bony Defects
The aim is of this study is to evaluate and compare the effects (clinical and radiological) of different biomaterials on the repair of bone defects around the teeth.
- Trial name
- NCT07292870
- Testing
- Minimally invasive surgical treatment of the intra-bony defects, Use of the xenograft Bio-Oss® Collagen during the surgery, Use of enamel matrix derivative (Emdogain®)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Disease
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
Dupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions.
- Trial name
- Micronerves (NCT06142929)
- Testing
- Microfasciectomy
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Disease
Ultrasound Features of Dupuytren's Disease
Dupuytren's disease (DD) is a benign and progressive condition that affects the palmar aponeurosis with a very high global incidence.
- Trial name
- Micro in DD (NCT06956027)
- Testing
- Ultrasound assesment, ROM measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prosthetic Joint Infection, Hip Prosthesis Infection
Long Term Follow-up of Patients With Prosthetic Joint Infection of the Hip Treated at University Hospitals Leuven
Prosthetic Joint Infection (PJI) of a Total Hip Replacement (THR) is a disastrous complication of an otherwise extremely successful surgical procedure.
- Trial name
- PROFITH (NCT05000723)
- Testing
- Standard of care
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Femoroacetabular Impingement
Biomechanical Investigation of Symptomatic FAI and Two Groups of Asymptomatic Controls
Femoroacetabular impingement (FAI) is an orthopaedic condition that is primarily characterized by the presence of anatomic bony abnormalities in the femoral head and/or the acetabulum resulting in an abnormal contact between the…
- Trial name
- CAM-FAI adult (NCT06272292)
- Testing
- EOS, 3D motion lab analysis
- Where
- Belgium
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Soft Tissue Sarcoma, Bone Sarcoma
Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients
Primary bone and soft tissue sarcomas are an exceptionally rare form of cancer, collectively accounting for only 1% of all malignancies diagnosed.
- Trial name
- QOLSarcoma (NCT05051059)
- Testing
- Functional outcome, Health related quality of life (HRQoL) assessment
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Volunteers
An Analysis of Healthy Caucasian Knees
In current literature, databases of healthy knee anatomy and function are confined to small sample sizes or singular imaging modalities.
- Trial name
- PC-CT KNEE (NCT07470671)
- Testing
- CT scan images of the knee, EOS scan of full leg, Ultrasound-based gap analysis
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ankle and Hindfoot Alterations
3D Multisegment Foot Model Used for the Clinical Outcome After Ankle and Hindfoot Reconstruction
Most symptomatic pathologies of the ankle and hindfoot are determined by biomechanical alterations of this anatomical region. Surgical treatment of these pathologies is therefore aimed at improving the inferior biomechanical…
- Trial name
- 3D-MFM (NCT04822558)
- Testing
- Plantar pressure measurement, Gait analysis, Ankle and hindfoot reconstruction surgery
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Primary Total Knee Arthroplasty
Journey Bicruciate Stabilized (BCS) Design and Legion Posterior Stabilized (PS) Design; Comparative Study
Today, primary total knee arthroplasty (TKA) is considered to be a safe and successful therapy for end-stage osteoarthritis of the knee.
- Trial name
- BCR (NCT04855864)
- Testing
- Follow-up of BCR TKA, Follow-up of BCS TKA, Follow-up of PS TKA
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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