Clinical trials: sponsored by KU Leuven
Healthy Volunteers
An Analysis of Healthy Caucasian Knees
In current literature, databases of healthy knee anatomy and function are confined to small sample sizes or singular imaging modalities.
- Trial name
- PC-CT KNEE (NCT07470671)
- Testing
- CT scan images of the knee, EOS scan of full leg, Ultrasound-based gap analysis
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spinal Deformity
Multimodal Bio-mechanical Analysis of Adult Spinal Deformity With Sagittal Plane Misalignment
A good understanding of the principles of balance is vital to achieve optimal outcomes when treating spinal disorders. A complex interaction of the neuromotor system and muscular recruitment is necessary for ergonomic balance and…
- Trial name
- ASD (NCT04812730)
- Testing
- 2D versus 3D analysis of EOS stereo radiographic analysis, Static versus dynamic analysis, Pre- versus postoperative analysis
- Where
- Belgium
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Knee Arthropathy, Return to Work
Determinants for Return to Work After Primary Knee Arthroplasty
The increase of end-stage osteoarthritis (OA) in an increasingly younger population is directly correlated with the rising incidence of obesity.
- Trial name
- RTW (NCT04665180)
- Testing
- Primary knee arthroplasty
- Where
- Belgium
- Volunteers
- 88 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adolescent Idiopathic Scoliosis
3D, Dynamic and Mechanically-informed Decision Making in AIS
Adolescent Idiopathic Scoliosis (AIS) is a growth defect of the spine that primarily occurs in prepubertal children between the age of 10 to 14 years, affecting approximately 3% of these otherwise normal children.
- Trial name
- 3D-AIS (NCT04761549)
- Testing
- Adolescent Idiopathic Scoliosis
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Disease
Palmaris Longus Muscle and Dupuytren
Dupuytren disease is a medical condition characterized by the painless formation of nodules in the palm of the hand. Cords are formed on the palmar fascia, a connective tissue sheet in the palm of the hand.
- Trial name
- Palmaris (NCT06281509)
- Testing
- Non-invasive tests to determine the presence or absence of the palmaris longus tendon in both hands., Ultrasound
- Where
- Belgium
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spinal Deformity
Balance Assessment Scale and Strength Measurement Protocol to Measure Functionality in Adults With Spinal Deformity
Develop reliable methods for functional assessment, for trunk strength, of Adult Spinal Deformity (ASD) patients and create a first clinical and normative database 1. Compare functionality of ASD and control subjects 2.
- Trial name
- F-ASD (NCT04642456)
- Testing
- Trunk strength measurement, EOS stereoradiographic full body exam
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cartilage Damage, Knee Injuries
Clinical Trial of an MRI Based Patient Specific Focal Knee Resurfacing Implant
The goal of this study is to evaluate the efficacy, safety and performance of the Episealer® device in a sample size of 30 patients and on the long term (10 years follow-up).
- Trial name
- Episealer2 (NCT03755388)
- Testing
- Episealer
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Cirrhosis, Viral Pneumonia
Liver Cirrhosis Patients With Invasive Pulmonary Aspergillosis: in Depth Understanding Clinical Host Risk Factors
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection of the respiratory system, caused by a specific fungus called Aspergillus species.
- Conditions
- Liver Cirrhosis, Viral Pneumonia, Fungal Infection, Invasive Pulmonary Aspergillosis
- Trial name
- LIVERIPA (NCT07238114)
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cow's Milk Protein Allergy
Post-failure Stepwise Heat-Denaturated Protein Introduction for Tolerance Induction in Cow's Milk Allergy Observational Cohort Study
Subjects who failed to become tolerant within 12 months after randomization within one of the three arms in the TEHITI study, can participate in the post-TEHITI observational trial to study the natural tolerance induction process.
- Trial name
- Post-TEHITI (NCT07448740)
- Where
- 5 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gingival Recession, Orthodontic Treatment
Gingival Recessions in Orthodontically Treated and Untreated Adult Patients
To identify the predisposing parameters for gingival recessions in adult patients seeking orthodontic treatment. The ultimate aim is to provide a clinical guideline to estimate the risk of developing post-orthodontic gingival…
- Trial name
- NCT07445555
- Testing
- Registration of parameters
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Systemic Availability, Intestinal Absorption
The Systemic Concentration of Short-Chain Fatty Acids After Delivery in the Small and Large Intestine of Healthy Volunteers
The goal of this crossover study is to evaluate the systemic availability of short-chain fatty acids (SCFA) that are either administered in the small intestine or the colon in healthy volunteers.
- Conditions
- Systemic Availability, Intestinal Absorption, Metabolism, Short-chain Fatty Acids
- Trial name
- Sistine (NCT06082726)
- Testing
- SCFA
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Satiety Hormones, Short-chain Fatty Acids
The Impact of Short-Chain Fatty Acids on Gut Hormone Release After Delivery in the Small and Large Intestine of Healthy Volunteers
The goal of this crossover study is to evaluate the impact of short-chain fatty acids (SCFA) on the gut hormone release after administration in the small intestine or colon in healthy participants.
- Conditions
- Satiety Hormones, Short-chain Fatty Acids, Satiety and Appetite, Intestinal Absorption
- Trial name
- Histine (NCT06686888)
- Testing
- SCFA, microcristalline cellulose
- Where
- Belgium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Exogenous Ketosis, Endurance Cycling Performance
The Effects of Exogenous Ketosis on Ultra-endurance Recovery and Performance
The study aims to investigate the effects of post-exercise and pre-sleep ketosis via oral ketone ester supplementation on physical and mental recovery during a multi-day cycling stage race.
- Conditions
- Exogenous Ketosis, Endurance Cycling Performance, Fatigue; Muscle, Heart, Fatigue, Mental
- Trial name
- NCT06965491
- Testing
- Ketone ester supplement
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Chronic Subdural Hematoma, Chronic Subdural Hematomas
Implementation of an Enhanced Recovery Pathway for Burr-hole Drainage in Patients With a Chronic Subdural Hematoma
A chronic subdural hematoma (cSDH) is a type of intracranial hematoma that primarily affects older adults. The rising incidence of this condition, coupled with the high healthcare burden of this disease, calls for an update of…
- Trial name
- ERP-cSDH (NCT07421453)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 2 Diabetes Mellitus (T2DM)
The Digital Diabetes Patient Reminder (DIPAR) Tool For Adults With Type 2 Diabetes
Digital health tools may present an opportunity to address these challenges by enhancing care delivery, improving patient engagement, and facilitating better disease management for chronic diseases such as type 2 diabetes…
- Trial name
- DIPAR RCT (NCT07257822)
- Testing
- Digital Diabetes Patient Reminder Tool, Standard of Care treatment and follow-up
- Where
- 2 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- KU Leuven
Esophageal Cancer, Gastric Cancer
Molecular Analysis for Gastro-Esophageal Cancer: Multicenter Discrete Choice Experiment
The goal of this survey is to investigate the participants' preference for a specific screening/diagnostic tool to detect and assess gastro-esophageal cancer.
- Trial name
- MAGECmultiDiCE (NCT06346080)
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Parkinson's Disease (PD)
Untreated Parkinson's Disease Work-up Assessing Resident Microbiota and Duodenal Barrier Function
The UPWARD study is a prospective hypothesis-generating study in individuals with untreated Parkinson's disease (PD) and age-matched healthy controls (HCs).
- Trial name
- UPWARD (NCT07418658)
- Testing
- Invasive sampling procedures, Non-invasive sampling procedures
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Cancer, Gastric Cancer
Molecular Assessment for Gastro-Esophageal Cancer
The goal of this minimally invasive interventional study is to learn if oncometabolic biomarkers, detected in the exhaled breath and blood can identify early-stage gastro-oesophageal cancer in patient at risk for…
- Conditions
- Esophageal Cancer, Gastric Cancer, Barrett Esophagus
- Trial name
- MAGEC (NCT06346054)
- Testing
- Breath analysis, Blood analysis
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- KU Leuven
ADHD, Sleep
Sleep IntervEntion as Symptom Treatment for ADHD
Up to 72% of adolescents with ADHD portray sleep problems. The most common sleep difficulties in adolescents with ADHD are initial insomnia, nocturnal awakenings, non-restorative or restless sleep.
- Conditions
- ADHD, Sleep, Adolescents, CBT
- Trial name
- SIESTA (NCT04723719)
- Testing
- SIESTA, Treatment as usual for ADHD
- Where
- Belgium
- Volunteers
- 92 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Periodontitis, Halitosis
The Additional Effect of Tongue Scraping on Halitosis Parameters in Initial Periodontal Therapy
Periodontitis can lead to tooth loss which may impair chewing ability and aesthetics. In addition, periodontitis can give rise to halitosis.
- Conditions
- Periodontitis, Halitosis, Tongue Condition
- Trial name
- NCT06091228
- Testing
- tongue scraper
- Where
- Belgium
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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