Clinical trials: sponsored by Kaiser Permanente
Dementia, Alzheimer Disease
The Brain Health Study: A Pragmatic, Patient-Centered Trial
The eRADAR Brain Health Study seeks to refine and test a novel, low-cost strategy for increasing dementia detection within primary care.
- Trial name
- NCT05356702
- Testing
- Brain Health Assessment
- Where
- 5 sites in United States
- Volunteers
- 3,417 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
ASCVD, Diabetes
Adherence to Dyslipidemia Therapy: Harnessing Evidence From Randomized Evaluations in AtheroSclerotic CardioVascular Disease
The goal of the ADHERE-ASCVD study is to evaluate and optimize patient-facing messaging strategies to improve statin refill and adherence among adults with atherosclerotic cardiovascular disease (ASCVD) or diabetes.
- Trial name
- ADHERE-ASCVD (NCT07522645)
- Testing
- SMS (Initial Outreach), Secure Portal Message (Initial Outreach), Non-secure Email (Initial Outreach)
- Where
- United States
- Volunteers
- 22,000 people
- Sponsor
- Kaiser Permanente
Chronic Obstructive Pulmonary Disease (COPD), Exacerbation of COPD
Laying the Foundation for Building a Resilient KPNC Community in the Face of Worsening Air Quality Due to Wildfire Smoke
The overarching goal of this project is to conduct a pilot intervention in high-risk Kaiser Permanente Northern California patients with chronic obstructive pulmonary disease to mitigate their exposure to poor air quality and…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Exacerbation of COPD, Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- DS-F (NCT07118189)
- Testing
- N95 masks and indoor air cleaner
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kaiser Permanente
Heart Failure
Improving Risk Stratification of Emergency Department Patients With Acute Heart Failure
The primary goal is to build and test a previously developed and validated risk model and clinical decision support tool embedded within the electronic health record to improve risk stratification of emergency department (ED)…
- Trial name
- NCT06065761
- Testing
- Comprehensive ED heart failure management tool
- Where
- 21 sites in United States
- Volunteers
- 17,459 people
- Sponsor
- Kaiser Permanente
Pediatric Cancer, Animal-Assisted Activities
Helping Improve Pediatric Patient Outcomes
This study involves two distinct activities: The first is a randomized controlled trial (RCT) to assess the efficacy and safety of therapy dog visits for children with cancer.
- Trial name
- HIPPO (NCT03471221)
- Testing
- Therapy Dog Visit
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Kaiser Permanente
Opioid-use Disorder
PRimary Care Opioid Use Disorders Treatment (PROUD) Trial
Effective treatment for opioid use disorders (OUDs) requires medications. Two medications for treating OUDs-buprenorphine and injectable naltrexone-can be prescribed in primary care (PC).
- Trial name
- PROUD (NCT03407638)
- Testing
- PROUD Intervention
- Where
- 6 sites in United States
- Volunteers
- 377,373 people
- Sponsor
- Kaiser Permanente
Multiple Chronic Conditions, Social Needs
Addressing Social Needs to Improve Health in Adults With Multiple Chronic Conditions
The investigators will conduct a comparative effectiveness randomized clinical trial with two "active comparator" arms. The investigators will evaluate the two current, usual care strategies (higher intensity "telephonic…
- Conditions
- Multiple Chronic Conditions, Social Needs, Care Gaps, Navigation
- Trial name
- NCT06941519
- Testing
- Telephonic Outreach, Virtual Outreach
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Kaiser Permanente
Type 1 Diabetes
Expansion of the T1DES Pilot to a Public Hospital
Diabetes distress has been identified as one of the largest contributors to the racial disparity in glycemic control that disproportionately burdens Black patients ages 18-30 years with type 1 diabetes (T1D).
- Trial name
- NCT06494722
- Testing
- Diabetes Education, T1DES
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Sciatica Acute, Sciatica Pain
Ultrasound-guided Transgluteal Sciatic Nerve Hydrodissection for the Treatment of Sciatica in the Emergency Department
The goal of this observational study is to see whether it would be feasible to treat patients who come to the emergency department with pain related to sciatica using an ultrasound guided injection of dextrose in water solution…
- Trial name
- NCT07588126
- Testing
- Ultrasound guided transgluteal sciatic nerve hydrodissection
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Kaiser Permanente
Type1diabetes
Type 1 Diabetes Education and Support Study
Diabetes distress has been identified as one of the largest contributors to the racial disparity in glycemic control that disproportionately burdens Black patients ages 18-30 years with type 1 diabetes (T1D).
- Trial name
- T1DES (NCT05735340)
- Testing
- Diabetes Education, T1DES
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Kaiser Permanente
School Health Services
Multilevel Peer-to-Peer HPV Vaccination and Wellness Educational Program in School Based Health Centers
School-based health centers (SBHCs) are an important setting to improve health through detecting, managing and preventing chronic illness.
- Trial name
- PEER (NCT07412743)
- Testing
- Mailers, Provider Materials, Peer-to-Peer Educational Sessions
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Kaiser Permanente
Depression
Outreach to Reduce Depression Disparities
Previous research by Mental Health Research Network (MHRN) investigators and others demonstrates that online messaging and other telehealth technologies can effectively and efficiently address premature discontinuation of…
- Trial name
- NCT05580406
- Testing
- Outreach messaging
- Where
- 2 sites in United States
- Volunteers
- 309 people
- Sponsor
- Kaiser Permanente
Pleural Effusion
Tenecteplase (TNK) for Loculated Pleural Effusions in Patients With Malignancy
The objective of the study is to determine the safety and efficacy of TNK infusion for the treatment of loculated pleural effusions in patients with known malignancy compared to normal saline infusion.
- Trial name
- NCT01580618
- Testing
- normal saline, TNK (Tenecteplase)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kaiser Permanente
Drug Use Disorders, Illicit Drug Use
Digital Treatments for Opioids and Other Substance Use Disorders in Primary Care
The DIGITS Trial addresses a critical knowledge gap: How to best implement digital treatments for opioids and other substance use disorders in primary care.
- Conditions
- Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders, Opioid Use Disorder
- Trial name
- DIGITS (NCT05160233)
- Testing
- Standard implementation, Health Coaching, Practice Facilitation
- Where
- United States
- Volunteers
- 18,430 people
- Sponsor
- Kaiser Permanente
Depression, Anxiety
More Individualized Care: Assessment and Recovery Through Engagement
The MI-CARE trial tests 12 months of telephone-based nurse care management for patients with depressive symptoms who take or have taken opioids at some time.
- Conditions
- Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
- Trial name
- MI-CARE (NCT05122676)
- Testing
- More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
- Where
- 2 sites in United States
- Volunteers
- 805 people
- Sponsor
- Kaiser Permanente
Adolescent Behavior, Mental Health Issue
Assisted Identification and Navigation of Early Mental Health Symptoms in Children
The randomized, two-arm pragmatic trial will test the effectiveness of offering 6-months of telephonic support from a mental health (MH) navigator to promote early access, engagement, coordination, and personalization of mental…
- Trial name
- MH Nav (NCT05064293)
- Testing
- Navigation Arm, Control Arm
- Where
- 2 sites in United States
- Volunteers
- 358 people
- Sponsor
- Kaiser Permanente
Mild Cognitive Impairment (MCI)
AI-Supported Cognitive Rehabilitation for Older Adults With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is associated with increased risk of progression to dementia, highlighting the need for accessible interventions to support cognitive health.
- Trial name
- ReMind-AI (NCT07474038)
- Testing
- AI-Supported Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Kaiser Permanente
Drug Use Disorders, Alcohol-Related Disorders
Addressing Barriers to Care for Substance Use Disorder Trial
The Addressing Barriers to Care for Substance Use Disorder Trial (ABC-SUD) is a cluster-randomized crossover trial, with clinicians (care coordinators) as the unit of randomization.
- Conditions
- Drug Use Disorders, Alcohol-Related Disorders, Substance Use Disorder (SUD)
- Trial name
- ABC-SUD (NCT06729957)
- Testing
- Care Navigation
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Kaiser Permanente
Serious Mental Illness, Type 2 Diabetes
MetSense Pilot and Feasibility
People with serious mental illness have high risk for type 2 diabetes due to multiple risk factors, including the metabolic side effects of psychotropic medications that are used to treat these conditions.
- Trial name
- MetSenseP&F (NCT07264062)
- Testing
- MetSense Risk Flag, Usual Care
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Kaiser Permanente
Depression, Anxiety
Filipino Family Health Initiative 1.0
The goal of this clinical trial is to test the effectiveness of an online parenting program on Filipino parents living in California.
- Conditions
- Depression, Anxiety, Parenting
- Trial name
- FFHI (NCT06569303)
- Testing
- Incredible Years® School Age Basic Parent Training Program, American Academy of Pediatrics, Bright Futures Handouts
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente