Clinical trials: sponsored by Kaiser Permanente
Alcohol Use Disorder (AUD), Pharmacist-Patient Relations
Alcohol Telemedicine Consultation in Primary Care (ATC)
This pragmatic, cluster-randomized trial in adult primary care clinics in a healthcare system with a diverse membership will examine the effectiveness of an innovative, multi-faceted intervention, the Addiction Telemedicine…
- Conditions
- Alcohol Use Disorder (AUD), Pharmacist-Patient Relations, Alcohol Problem
- Trial name
- ATC (NCT05252221)
- Testing
- ATC Intervention
- Where
- 2 sites in United States
- Volunteers
- 41,843 people
- Sponsor
- Kaiser Permanente
Overweight, Obese
Post-delivery Maternal-offspring Obesity and Metabolic Risk After a Prepregnancy Weight-loss Intervention
The goal of PrepareD is to examine whether the prepregnancy weight-loss intervention administered during the Prepare trial [NCT02346162] has an influence in the postnatal period.
- Conditions
- Overweight, Obese, Metabolic Disorders, Postpartum
- Trial name
- PrepareD (NCT06067126)
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Kaiser Permanente
Colorectal Cancer
Predicting and Addressing Colonoscopy in Safety Net Settings
The prospective cohort study will evaluate the effectiveness of patient navigation in community health center settings. The investigators will collaborate with the advisory board, composed of key clinicians and patients…
- Trial name
- PRECISE (NCT03925883)
- Testing
- Patient navigation
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Kaiser Permanente
Total Knee Replacement Surgery
Adductor Canal Catheter Effectiveness and Safety Study
PRIMARY OBJECTIVE: Compare the effect of usual care with an adductor canal catheter (ACC) containing ropivacaine to the effect of usual care without an ACC on the second-postoperative-day pain levels among patients undergoing…
- Trial name
- ACCESS (NCT04639128)
- Testing
- Adductor Canal Catheter
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Kaiser Permanente
Genital Herpes Simplex, Maternal Morbidity
Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity
Severe Maternal Morbidity (SMM) has been associated with maternal mortality, fetal risk, and long-term maternal risk. African American (AA) women are at consistently higher risk than White women.
- Conditions
- Genital Herpes Simplex, Maternal Morbidity, Racial Disparities
- Trial name
- PCORISMM (NCT05429346)
- Where
- United States
- Volunteers
- 339,000 people
- Sponsor
- Kaiser Permanente
Breast Cancer
Radiologic Evaluation and Breast Density (READ)
The purpose of this study is to determine whether cessation of hormone replacement therapy for one or two months before a screening mammogram will improve its performance by decreasing breast density.
- Trial name
- NCT00117663
- Testing
- temporary discontinuation of hormone therapy for 1 month, temporary discontinuation of hormone therapy for 2 months
- Where
- United States
- Volunteers
- 1,704 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Back Pain Lower Back Chronic
Tai Chi for Chronic Low Back Pain in Older Adults
There is a major gap in knowledge about safe and effective treatment options for older adults with chronic low back pain. This project will determine the feasibility of conducting a full-scale trial evaluating Tai Chi, a…
- Trial name
- NCT03299192
- Testing
- Tai Chi, Health Education, Usual Medical Care
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Kaiser Permanente
Smoking, Smoking Cessation
Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV
This pilot study will assess the acceptability and feasibility a novel mHealth app designed for smokers who are ambivalent about quitting and have been diagnosed with HIV.
- Trial name
- NCT05339659
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Kaiser Permanente
Atrial Fibrillation and Flutter
Clinical Decision Support for Atrial Fibrillation and Flutter
Atrial fibrillation (AF) is a major public health problem: it impairs quality of life and independently heightens the risks of ischemic stroke, heart failure and all-cause mortality.
- Trial name
- NCT05009225
- Testing
- Comprehensive ED AF management tool
- Where
- 16 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Kaiser Permanente
Syncope
Improving Management of Emergency Department Patients With Undifferentiated Syncope: Prospective Validation of the Canadian Syncope Risk Score
Among Kaiser Permanente Northern California (KPNC) health plan members, age ≥16 years, with recent syncope and presyncope undergoing emergency department (ED) management with a point-of-care clinical decision support (CDS) tool…
- Trial name
- NCT05538143
- Testing
- Comprehensive ED syncope/presyncope management tool
- Where
- 5 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Kaiser Permanente
COVID-19, Quality of Care
Pharmacist Management of Paxlovid eVisits
The goal of this cluster randomized trial is to compare two modes of management -- pharmacist care vs. pooled adult and family medicine physician care -- for electronically submitted requests (e-visits) for Paxlovid by adults…
- Trial name
- NCT06076863
- Testing
- Pharmacist Care, AFM Pool Care
- Where
- United States
- Volunteers
- 2,478 people
- Sponsor
- Kaiser Permanente
Lymphocele, Prostate Cancer
Ultrasound Guided Inguinal Indocyanine Green Injection to Identify and Pre-emptively Seal Lymphatic Leaks
Goal is to determine whether intraoperative ICG injection can be used to identify and reduce formation of symptomatic lymphoceles in patients receiving robot-assisted prostatectomy.
- Trial name
- NCT06258486
- Testing
- ICG injection, Non-Injection/Control, Prostatectomy with pelvic lymph node dissection
- Volunteers
- 100 people
- Sponsor
- Kaiser Permanente
Lynch Syndrome, Colorectal Cancer
Family History Study on Cancer Risk
This study aims to identify the optimal method to recognize, risk stratify, and provide follow-up care for individuals at risk of hereditary cancer.
- Conditions
- Lynch Syndrome, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT04145388
- Testing
- online cancer risk assessment, Usual care
- Where
- United States
- Volunteers
- 18,623 people
- Sponsor
- Kaiser Permanente
Suicide, Suicide, Attempted
Now Matters Now: An Online Suicide Prevention Program
In the United States in 2010, 38,000 people died from suicide and it is our nation's 10 leading cause of death. Suicide prevention is a national priority and yet secondary prevention programs targeting those most at risk are…
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation
- Trial name
- NMN_SSIP (NCT01924936)
- Testing
- DBT Online Program
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Kaiser Permanente
Dementia
Optimal Medication Management in Alzheimer's Disease and Dementia
The study objective is to conduct a pragmatic deprescribing intervention for people with Alzheimer's Disease or Related Dementia with Multiple Chronic Conditions (ADRD-MCC) so that these patients are on 'just right' medication…
- Trial name
- Optimize (NCT03984396)
- Testing
- Educational Materials - Patient & Clinician
- Where
- United States
- Volunteers
- 7,398 people
- Sponsor
- Kaiser Permanente
Type 2 Diabetes
Overcoming Therapeutic Inertia Among Adults Recently Diagnosed With Type 2 Diabetes
Therapeutic inertia may result from providers, patients, and/or systems, but can be detrimental to a patients' health by putting them at risk for diabetes complications, though addressing it early can mitigate some of its…
- Trial name
- NCT05566847
- Testing
- Physician Education, Accountable Population Manager outreach
- Where
- United States
- Volunteers
- 817 people
- Sponsor
- Kaiser Permanente
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma (PDAC)
PRedictiOn Algorithms for the DeTECTion of Early Stage Pancreatic Cancer
Conduct a prospective study to assess the accuracy of a pancreatic cancer risk prediction model.
- Trial name
- PRO-TECT (NCT04883450)
- Testing
- Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Kaiser Permanente
Obesity, Bariatrics
Comparing the Benefits and Harms of Three Types of Weight Loss Surgery -- The PCORnet® Bariatric Study
The main goal of this research project is to conduct a comparative effectiveness research study involving existing data in the PCORnet Common Data Model to provide accurate estimates of the 1-, 3-, and 5-year benefits and risks…
- Conditions
- Obesity, Bariatrics, Body Weight, Diabetes Mellitus
- Trial name
- PBS (NCT02741674)
- Testing
- Roux-en-y gastric bypass (RYGB) - historical, Adjustable gastric banding (AGB) - historical, Sleeve gastrectomy (SG) - historical
- Volunteers
- 65,093 people
- Sponsor
- Kaiser Permanente
Polypharmacy
Bundled Hyperpolypharmacy Deprescribing
Older patients using many prescription drugs (hyperpolypharmacy) may be at increased risk of adverse drug effects. This randomized controlled trial tested the effectiveness and safety of a quality intervention intended to reduce…
- Trial name
- NCT05616689
- Testing
- Bundled hyperpolypharmacy
- Where
- United States
- Volunteers
- 2,471 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Lung Neoplasm
Inspiratory Muscle Training and Behavioral Support to Alleviate Dyspnea and Promote Walking in Lung Cancer Survivors: A Pilot Study
This is a pilot randomized study to investigate the feasibility, acceptability, safety, and effects of a novel tele-rehabilitation intervention for stage I-IIIA lung cancer survivors following curative intent therapy.
- Trial name
- NCT05059132
- Testing
- Tele-rehabilitation, Education only
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kaiser Permanente