Clinical trials: sponsored by Kessler Foundation
Aging
Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in an aging population.
- Trial name
- NCT06269939
- Testing
- STEM
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis.
- Trial name
- STEM (NCT03983681)
- Testing
- Strategy-Based Training to Enhance Memory (STEM)
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Spinal Cord Injuries, Hypotension
Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury
The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.
- Conditions
- Spinal Cord Injuries, Hypotension, Orthostatic Hypotension, Spinal Cord Diseases
- Trial name
- (SCI) (NCT07674511)
- Testing
- Tilt test with stimulation (real-time effects): Intervention 1, 20 sessions of stimulation (Intervention 2)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Stroke, Dyslexia, Acquired
Neurofeedback Intervention for Reading Deficits in Subacute Stroke
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation.
- Trial name
- ReadingNFB (NCT04875936)
- Testing
- Motor Imagery and Real-Time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Stroke, Aphasia
Enhancing Reading Recovery in Aphasia With tDCS and Phonomotor Therapy
This study is designed for individuals with aphasia, a language disorder that affects many stroke survivors, making it difficult to read, speak, and understand language.
- Trial name
- NCT06891638
- Testing
- Schedule of tDCS administration
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Kessler Foundation
Stroke, Chronic Stroke Patients
The Safety and Effectiveness of Q Therapeutic System, Frequency-tuned Electromagnetic Field Treatment in Facilitating the Recovery of Patients With Chronic Stroke.
This trial will test a promising new intervention to promote post-stroke neural reorganization and functional recovery. The overall aim is to identify a systematic, methodological approach to system fitting, training protocols…
- Trial name
- RESPARK (NCT07499310)
- Testing
- Experimental (Q Therapeutic System (BQ 3.0)
- Volunteers
- 25 people
- Sponsor
- Kessler Foundation
Bone Marrow Edema, Knee Osteoarthritis
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
Subchondral bone marrow lesions (BMLs) in knee osteoarthritis (OA) are strongly associated with presence and severity of knee pain, structural deterioration, disease progression with an increased risk of total knee arthroplasty.
- Conditions
- Bone Marrow Edema, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NCT05596591
- Testing
- Focused extracorporeal shockwave therapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries, Spasticity, Muscle
Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
People with spinal cord injury (SCI) experience a host of secondary complications that can impact their quality of life and functional independence.
- Conditions
- Spinal Cord Injuries, Spasticity, Muscle, Spastic Paraplegia, Spastic Quadriplegia
- Trial name
- NCT05432999
- Testing
- Extracorporeal Shockwave Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury, Ambulation Difficulty
Exoskeleton and Spinal Cord Stimulation for SCI
The overall aim of this project is to assess the effect of combining transcutaneous lumbosacral stimulation (TLS) during Exoskeleton Assisted Walking (EAW) compared to EAW alone without stimulation on walking recovery.
- Conditions
- Spinal Cord Injury, Ambulation Difficulty, Muscle Spasticity
- Trial name
- NCT03096197
- Testing
- Exoskeleton-Assisted Walking, Transcutaneous Lumbosacral Stimulation (TLS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kessler Foundation
Stroke, Spatial Neglect
Family-Clinician Collaboration to Improve Neglect and Rehabilitation Outcome After Stroke
Spatial neglect may occur in patients who have had a stroke. People with spatial neglect often pay much more attention to one side of the body while ignoring the other side, even though they have no difficulty seeing.
- Trial name
- NCT03402906
- Testing
- Family-Clinician Collaboration Program
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Kessler Foundation
SCI - Spinal Cord Injury, Upper Extremity Dysfunction
The Utilization Effects of Powered Wearable Orthotics in Improving Upper Extremity Function and ADL in Persons With SCI
To evaluate the usefulness of an upper extremity assistive device, called (MyoPro) in improving upper extremity activities in people with incomplete spinal cord injury. The Department of Defense is supporting this study.
- Conditions
- SCI - Spinal Cord Injury, Upper Extremity Dysfunction, Upper Extremity Problem
- Trial name
- NCT06349434
- Testing
- MyoMo, conventional therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis, Gait Disorders, Neurologic
Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS
The purpose of this research study is to evaluate the usefulness of a wearable robotic exoskeleton device (Ekso-GT), to improve learning and memory, and gait therapy in persons with walking disability due to Multiple Sclerosis.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Motility Disorder, Cognitive Impairment
- Trial name
- NCT04855825
- Testing
- Robotic Exoskeleton Rehabilitation, Conventional Gait Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Effects of Cycling and Virtual Reality on Thinking Speed in Persons With MS (PACE-MS)
To compare the effects of cycling exercise with different types of virtual reality on processing/thinking speed in persons with multiple sclerosis (MS).
- Trial name
- PACE-MS (NCT06191380)
- Testing
- PACE-MS
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Kessler Foundation
Cancer-related Fatigue, Neuromodulation
tDCS for Cancer-Related Fatigue and Weakness
This pilot study investigates the effectiveness of non-invasive brain stimulation (tDCS) in alleviating cancer-related fatigue (CRF) and muscle weakness.
- Trial name
- NCT07159100
- Testing
- Active tDCS + elbow flexion exercise
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Parkinson Disease
Investigation of Effects of Delayed Feedback on Non-motor Symptoms in Individuals With Parkinson's Disease
Learning deficits are frequent in individuals with Parkinson's Disease. Clear feedback is integral because through feedback individuals know whether they should stick with an action that they have been doing (if the feedback is…
- Trial name
- NCT06217484
- Testing
- delayed feedback
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury
Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury
New learning and memory impairment (NLMI) is a common and devastating manifestation of TBI associated with substantial life burdens. Persons with moderate to severe TBI have shown improvement in NLM for prose material (e.g.
- Trial name
- CRUSH-IT (NCT05716048)
- Testing
- KF-mSMT Plus Aerobic Exercise Training, KF-mSMT Plus Stretching Exercise Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury, Traumatic Brain Injury (TBI)
Spinal Stimulation and Gait Training to Improve Mobility in TBI
The purpose of this research study is to assess the effects of receiving transcutaneous spinal stimulation while performing walking exercises compared to completing walking exercises without spinal stimulation for individuals…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI), Hemiplegia and Hemiparesis
- Trial name
- DOD SS (NCT06886152)
- Testing
- Transcutaneous Spinal Cord Stimulation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Fatigue in Multiple Sclerosis
Testing the Effects of Methylphenidate on Multiple Sclerosis
Up to 95% of individuals with Multiple Sclerosis report experiencing cognitive fatigue, characterized by a lack of energy, feelings of exhaustion, an the perception that one is unable to partake in daily activities.
- Trial name
- NCT02286557
- Testing
- Methelphenidate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries, Hypotension
The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)
This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic…
- Conditions
- Spinal Cord Injuries, Hypotension, Orthostatic Hypotension, Spinal Cord Diseases
- Trial name
- SCI (NCT05725499)
- Testing
- Biostim-5 transcutaneous spinal stimulator, Tilt-table orthostatic stress testing
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kessler Foundation