Clinical trials: sponsored by Laval University
Metabolic Syndrome
Effects of Polyunsaturated Fatty Acids on Intestinal Lipid Metabolism in Insulin-resistant Men
The overaccumulation of apolipoprotein (apo)B-48-containing lipoproteins of intestinal origin observed in patients with insulin-resistance is now thought to be attributable to both elevated intestinal production and reduced…
- Trial name
- PUFA (NCT01934543)
- Testing
- Polyunsaturated fatty acids diet, Saturated fatty acids diet
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease
Substudy : Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Its prevalence is in progression and COPD is expected to become the fourth leading cause of death by 2030.
- Trial name
- EXA (NCT02282436)
- Testing
- No specific intervention for this study
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Patellofemoral Pain (PFPS)
A Controlled Trial on Recreational Runners With Patellofemoral Pain
From a rehabilitation point of view, while several approaches exist to retrain runners with PFPS, it is not clear which one is most effective, or why.
- Trial name
- NCT02352909
- Testing
- Education, Exercise program, Gait retraining
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- Laval University
Tobacco Use Disorder
Combining Noninvasive Brain Stimulation and Cognitive Training on Tobacco Craving
The purpose of this study is to determine whether combining noninvasive brain stimulation with cognitive training can reduce craving in adults with tobacco use disorder.
- Trial name
- NCT02810574
- Testing
- Cognitive training, Noninvasive brain stimulation (active)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Laval University
Tobacco Use Disorder
Effects of Non-invasive Brain Stimulation in Tobacco Use Disorder
The objective of the study is to determine the effect of non-invasive brain stimulation on craving for tobacco and brain metabolites.
- Trial name
- NCT02776319
- Testing
- Non-invasive brain stimulation (active)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Laval University
Metabolic Syndrome X
Effects of Selective Inhibition of Cholesterol Absorption With Ezetimibe on Intestinal Cholesterol Homeostasis in Dyslipidemic Men With Insulin-resistance - a Pilot Study
Ezetimibe has been shown to inhibit cholesterol absorption and several lines of evidence from in vitro systems and animal models suggest that this effect is associated with an increase in low-density lipoprotein (LDL) receptor…
- Trial name
- EZEmRNA (NCT01849068)
- Testing
- Ezetimibe
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Type 2 Diabetes Mellitus
Sitagliptin and Kinetics of Triglyceride-rich Lipoproteins Apolipoprotein B48 and B100 in Patients With Type 2 Diabetes
Sitagliptin is a potent and selective inhibitor of dipeptidyl peptidase IV (DPP-IV), and has been shown to reduce fasting and postprandial glucose levels in patients with type 2 diabetes mainly through incretin hormone-mediated…
- Trial name
- JANUB48 (NCT01334229)
- Testing
- Sitagliptin
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Laval University
Homozygous Familial Hypercholesterolemia
Comparisons of Two Low-density Lipoprotein Apheresis Systems in Patients With Homozygous Familial Hypercholesterolemia
Homozygous familial hypercholesterolemia (HoFH) is characterized by a six- to eight-fold raise in plasma LDL-cholesterol (LDL-C) concentrations and atherosclerotic coronary artery disease usually occur before the age of 20 if…
- Trial name
- APHERESE (NCT02286596)
- Testing
- heparin-induced extracorporeal LDL precipitation, dextran sulfate adsorption
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Laval University
Familial Hypercholesterolemia
Effects of LDL Apheresis System on the Expression of Genes Involved in Lipoprotein Metabolism and Inflammation in Homozygotes for Familial Hypercholesterolemia
Familial hypercholesterolemia (FH) is an autosomal codominant single-gene disorder caused by mutations in the LDL receptor gene that disrupt the normal clearance of LDL particles from the plasma compartment.
- Trial name
- LA-PBMC (NCT02462655)
- Testing
- Pre-lipid apheresis, Post-lipid apheresis
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Laval University
Osteoarthritis, Knee
Combination of Lateral Foot Orthoses and Knee Brace for Treatment of the Knee Osteoarthritis
The purpose of this study is to evaluate the immediate and short-term effects of the combination of lateral customized foot orthoses on the pain and medial knee loading during gait among medial knee osteoarthritis patients.
- Trial name
- NCT01870336
- Testing
- Combined treatment of medial knee osteoarthritis
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Laval University
COPD
Impact of COPD on Muscle Regeneration
Muscle weakness and atrophy are important consequences of chronic obstructive pulmonary disease (COPD) and can affect both respiratory and peripheral muscles.
- Trial name
- NCT02557165
- Testing
- Muscle biopsies
- Volunteers
- 27 people
- Sponsor
- Laval University
Cardiovascular Diseases, Vasodilation
Effects of n-3 Polyunsaturated Fatty Acids and Antioxidants on Postprandial Hyperlipidemia and Vascular Function in Men
Diet has long been used as a way to provide enough nutrients to an individual in order to meet metabolic requirements. However, recent scientific advancements have suggested that beyond meeting nutrition needs, diet may also be…
- Trial name
- NCT00296595
- Testing
- Nutrition
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Laval University
Effect of Resveratrol and Curcumin on Inflammation
Effect of Antioxidant Intake on Cardiovascular Risk
The general objective of this project is to investigate the acute effect of consuming a dietary supplement combining resveratrol and curcumin on the inflammatory response following the consumption of a high-fat meal in healthy…
- Trial name
- NCT01964846
- Testing
- Resveratrol, curcumin
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Laval University
Bronchiolitis
Impact Of A Health Care Protocol For Patients Suffering Symptoms Of Mild Acute Viral Bronchiolitis On Early Release In The Emergency Department
Acute viral bronchiolitis is the principal cause of lower respiratory tract infection in infants worldwide. It is characterized by a first episode of respiratory distress preceded by rhinorrhea, cough and fever.
- Trial name
- NCT01091064
- Testing
- Randomization early depart
- Where
- Canada
- Sponsor
- Laval University
Acute Viral Bronchiolitis.
HYPERTONIC SALINE IN ACUTE VIRAL BRONCHIOLITIS: A RANDOMIZED CLINICAL TRIAL
The purpose of this study is to determine whether nebulized hypertonic saline solution reduces the admission rate 48 hours after initial treatment in the emergency department, when compared to normal saline solution (placebo).
- Trial name
- NCT00729274
- Testing
- normal saline solution
- Where
- Canada
- Sponsor
- Laval University
Post-traumatic Stress Disorder
The Use of Noninvasive Brain Stimulation in Post-traumatic Stress Disorder
The purpose of this trial is to study the effect of noninvasive brain stimulation in adults with post-traumatic stress disorder.
- Trial name
- NCT02542709
- Testing
- Active repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Laval University
Diabetes, Cardiovascular Disease
Beneficial Effects of a Polyphenol Enriched Beverage on Type 2 Diabetes Prevention and on Cardiovascular Risk Profile of Men and Women With Insulin Resistance.
The purpose of this study is to measure the beneficial effects of an optimized berries extracts on diabetes and cardiovascular diseases prevention.
- Trial name
- NCT01766570
- Testing
- Uncontrolled nutritional intervention with a supplemental beverage
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Laval University
Obesity
Does Food Labeling Influence Long-term Food Intake and Eating-related Variables in Women?
Weight management is a critical issue in developed countries where the prevalence of obesity is always increasing. While the mismatch of energy intake and energy expenditure is recognized as a leading cause of obesity, knowledge…
- Trial name
- MENU (NCT01604954)
- Testing
- Nutrient-label, Calorie-label, No label
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Laval University
Overweight
Impact of Cognitive Dietary Restraint on Perceived Stress, Appetite Sensations, Food Cravings During Energy Restriction
The purpose of this study is to measure the effects of a reduced-calorie low energy density diet with and without increased cognitive dietary restraint (CDR) on stress (biological markers and perceived stress), eating behaviours…
- Trial name
- NCT02230111
- Testing
- Energy restriction plus CDR, Energy restriction without CDR
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Laval University
Asthma
Assessment of Shared Decision Making Aids in Asthma
The purpose of this study is to determine whether the use of shared decision making aids is more effective than usual care in improving asthma knowledge, lessening decisional conflict, and enhancing adherence to treatments and…
- Trial name
- NCT02516449
- Testing
- Patient decision aid
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Laval University