Clinical trials: sponsored by Laval University
Pulmonary Arterial Hypertension
Olaparib for PAH: a Multicenter Clinical Trial
The main OBJECTIVE of this proposal is to extend our preclinical findings on the role of DNA damage and poly(ADP-ribose) polymerases (PARP) inhibition as a therapy for a devastating disease, pulmonary arterial hypertension (PAH)…
- Trial name
- OPTION (NCT03782818)
- Testing
- Olaparib
- Where
- 3 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Laval University
Asthma
Residual Exacerbations With Mepolizumab
This will be a two-year prospective study to characterize the nature of the remaining asthma exacerbations in patients treated with mepolizumab.
- Trial name
- NCT04578171
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Laval University
Chronic Pain, Anxiety
Music Intervention in Chronic Pain Patients
The goal of this randomized controlled trial is to evaluate the efficacy of a personalized music intervention program to improve the condition of individuals suffering from chronic pain.
- Conditions
- Chronic Pain, Anxiety, Well-Being, Psychological
- Trial name
- MusicCPP (NCT06436378)
- Testing
- Music intervention in person
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Laval University
Palliative Care, Pain Management
Medical Hypnosis and Music for Palliative Care
The goal of this randomized controlled trial is to evaluate the efficacy of a personalized multimodal intervention program (MuzHyp) including hypnosis, music or their combination to improve palliative care at home.
- Conditions
- Palliative Care, Pain Management, Anxiety, Well-being
- Trial name
- MuzhypforPC (NCT05951257)
- Testing
- Personalized multimodal intervention involving hypnosis and/or music
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Oxygen Toxicity, COPD Bronchitis
Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates
Oxygen therapy is at the heart of the healthcare system. Oxygen flow rates depend on a number of confounding factors confounding factors (target used, skin pigmentation, pulse oximeter used, etc.) The investigators have recently…
- Conditions
- Oxygen Toxicity, COPD Bronchitis, Respiratory Failure
- Trial name
- Interfaces (NCT06646991)
- Testing
- Nasal canula - up to 6 liters per minute, Nasal canula - up to 15 liters per minute, Open oxygen mask
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Familial Hypercholesterolemia, Nutrition, Healthy
Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia.
The investigators will conduct a fully controlled dietary randomized crossover trial (RCT) including 10 adults with HeFH using lipid-lowering medication to investigate the impact of a diet low in red and processed meats and high…
- Conditions
- Familial Hypercholesterolemia, Nutrition, Healthy, Cholesterol, Elevated
- Trial name
- NCT06389825
- Testing
- Healthy diet
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Laval University
Cardiometabolic Risk
Impact of Ultra-processed Foods on Cardiometabolic Risk Factors
The goal of this clinical trial is to examine in a 2x2 factorial RCT what feature(s) of ultra-processed foods (UPFs) contribute to cardiometabolic risk in men and women. The project's hypotheses are : 1.
- Trial name
- NOVA (NCT06538831)
- Testing
- Diet N-P-, Diet N+P-, Diet N-P+
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Laval University
Alzheimer Disease, Dementia
CONSTELLATIONS Living Lab: Improving the Care Transitions of Older Adults Living with Neurocognitive Disorders
The prevalence of major neurocognitive disorders (MNCDs), particularly Alzheimer's disease, among older adults is increasing. These individuals and their caregivers often face challenges due to inefficient and poorly coordinated…
- Conditions
- Alzheimer Disease, Dementia, Neurocognitive Decline
- Trial name
- NCT06608589
- Testing
- CoMPAS+ MNCDs Program - Quality improvement program targeting the care transitions of patients living with a major neurocognitive disorder and their caregivers
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Laval University
Older Adults, Aging Well
Self-Adaptive Immersive Virtual Reality Serious Game to Enhance Motor Skill Learning and Attention in Older Adults
While scientific evidence emphasizes the detrimental effect of sedentary behavior on health, the literature suggests that, on average, older adults spend 75% of their days in a sedentary manner, and often isolated (Petrusevski…
- Conditions
- Older Adults, Aging Well, Aging
- Trial name
- SAVinGs (NCT06141642)
- Testing
- Self-adaptive serious game, Non-adaptive serious game
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Laval University
Metabolic Syndrome
Effects of Monounsaturated Fatty Acids on Intestinal Lipid Metabolism in Insulin Resistant Subjects (MUFA )
The overaccumulation of apolipoprotein (apo)B-48-containing lipoproteins of intestinal origin observed in patients with insulin-resistance is now thought to be attributable to both elevated intestinal production and reduced…
- Trial name
- NCT03872349
- Testing
- Monounsaturated fatty acids diet, Saturated fatty acids diet
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Laval University
Adiposity, Food Preferences
Visceral Adiposity, Vagal Tone and Food Preferences: a Pilot Study
Food preferences are defined by a number of measurable parameters, such as per se food choices, sensitivity of taste and olfactory sensory perceptions, hedonic appreciation of foods ("liking") and motivation to consume them…
- Conditions
- Adiposity, Food Preferences, Eating Behavior
- Trial name
- ObVague (NCT06175988)
- Testing
- Visceral adiposity
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Laval University
Binge-Eating Disorder
Compuls-BED-Severity
Binge Eating Disorder (BED) has been fairly recently introduced into the Diagnostic and Statistical Manual 5 psychiatric classification and its severity criteria are still not well established.
- Trial name
- NCT05149859
- Testing
- Observational
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Laval University
Type 1 Diabetes
Do "sugar Swings" Impact the Brain Function and the Eating Behaviors of People with Type 1 Diabetes
In type 1 diabetes, it is common to choose the food we eat according to the blood sugar level and the insulin dose and vice versa.
- Trial name
- NCT05487534
- Testing
- Observational
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- Laval University
Bariatric Surgery Candidate, Obesity
BariaPSY: the Data Bank
Multimorbidity, the co-occurrence of several chronic conditions, is a growing phenomenon that poses new challenges for clinicians and researchers.
- Trial name
- NCT05602805
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- Laval University
Type 1 Diabetes
Study of the Characteristics of Orthorexia Nervosa in the Population Living with Type 1 Diabetes
In the general population, the excessive and constant desire to control one's diet and body has become increasingly problematic.
- Trial name
- Santal-DT1 (NCT05546281)
- Testing
- No intervention
- Where
- 2 sites in Canada
- Volunteers
- 33 people
- Sponsor
- Laval University
Intensive Sleep Retraining, Total Sleep Deprivation
Intensive Sleep Retraining and Total Sleep Deprivation for Treating Chronic Insomnia
The present study was designed to evaluate the efficacy of intensive sleep retraining for treating insomnia and explore its potential mechanisms of action.
- Conditions
- Intensive Sleep Retraining, Total Sleep Deprivation, Control Condition
- Trial name
- NCT06615336
- Testing
- Intensive Sleep retraining, Total Sleep Deprivation
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Laval University
Wheelchair Mobility, Manual Wheelchair Skills Training
Wheelchair Skills Training for People with ARSACS and DM1
Wheelchairs (WC) are often provided to people with ARSACS and MD1 when they are not able to walk anymore. However, giving someone a MWC alone does not guarantee they will use it safely or properly.
- Conditions
- Wheelchair Mobility, Manual Wheelchair Skills Training, ARSACS, Myotonic Dystrophy Type 1
- Trial name
- NCT06596850
- Testing
- Wheelchair Skills Training Program
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Vaccine-Preventable Diseases
An Evaluation of a Dynamic Web-Based Visualization of Community Immunity
This study is a PhD project conducted by Ms. Hina Hakim, supervised by Dr. Holly O. Witteman, PhD, and co-supervised Dr. Daniel Reinharz, professors and researchers at the Faculty of Medicine at Laval University.
- Trial name
- NCT04787913
- Testing
- herdimm, guardianmeasles, theotheredmundmeasles
- Where
- Canada
- Volunteers
- 5,516 people, healthy volunteers welcome
- Sponsor
- Laval University
Survey
Using Survey to Explore Perceptions of Adults With Low Socioeconomic Status Regarding the NutriQuébec Study
Populations with low socioeconomic status (SES) are more likely to develop diseases across lifespan and are frequently underrepresented in large cohort studies.
- Trial name
- NCT03847584
- Testing
- Survey
- Where
- Canada
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Laval University
Focus Groups
Using Focus Groups to Explore Perceptions of Adults With Low Socioeconomic Status Regarding the NutriQuébec Study
NutriQuébec is a web-based prospective cohort study aiming to monitor and analyse the evolution of Québec population eating habits through annual questionnaires.
- Trial name
- NCT03849846
- Testing
- Focus groups
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Laval University