Clinical trials: sponsored by Laval University
Achilles Tendinopathy
Influencing Factors of Acute Achilles Tendinopathy in Runners
Achilles tendinopathy is highly prevalent in runners, but its evolution is not easily predictable. The aim of this study is to evaluate the impact of clinical and social factors on the prognosis of acute (less than 3 months)…
- Trial name
- AchTend (NCT05677204)
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- Laval University
Obesity, Visceral, Diet, Healthy
Long-term Benefits of Abdominal Fat Loss in Abdominally Obese Dyslipidemic Patients (SYNERGIE Study)
The objective of this clinical trial is to verify whether the beneficial effects of weight loss on visceral fat measured by computed tomography and metabolic risk factors for coronary heart disease are maintained once high-risk…
- Conditions
- Obesity, Visceral, Diet, Healthy, Cardiometabolic Syndrome, Lifestyle-related Condition
- Trial name
- SYNERGIE (NCT06158191)
- Testing
- Lifestyle modification program
- Volunteers
- 186 people
- Sponsor
- Laval University
Ischemic Mitral Regurgitation
Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
This study is intended to investigate the effect of cyproheptadine (a 5HT2B receptor blocker) on mitral regurgitation severity.
- Trial name
- CYPRO-MR (NCT05469165)
- Testing
- Cyproheptadine 4 Mg Oral Tablet
- Where
- Canada
- Volunteers
- 214 people
- Sponsor
- Laval University
Musculoskeletal Disorder
Workplace Rehabilitation for Musicians: Program Optimisation and Evaluation
Background: The classical musician's work, which comprises numerous daily hours of precise and often strenuous repetitive movements in asymmetrical postures, renders them vulnerable to musculoskeletal (MSK) injury.
- Trial name
- NCT03837106
- Testing
- Rehabilitation program
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Laval University
Stress Disorders, Post-Traumatic
IRT and CBT in Sexual Assault Victims With PTSD
Sexual assault victims (SAV) have an elevated risk of developing posttraumatic stress disorder (PTSD). Trauma-focused cognitive-behavioural therapy (CBT) is an effective first-line treatment for this pathology.
- Trial name
- NCT03169712
- Testing
- Cognitive Behavioral Therapy for PTSD, Imagery Rehearsal Therapy
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Laval University
Obesity
Full-fat Dairy Products, Body Weight Control and Metabolic Health
The aim of this research is to clarify the role of different dairy products including both full-fat and low-fat dairy in maintaining health in adults and children through its effects beyond their well-known contribution of…
- Trial name
- NCT05417347
- Testing
- Low-fat dairy products, Full-fat dairy products
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Laval University
Weight Loss, Weight Maintenance
Satiating Diet, Appetite Control and Body Weight Loss in Individuals With Obesity
The objective of this study is to evaluate (1) the effect of a non-restrictive satiating intervention on appetite control, body weight loss and maintenance; and (2) determine whether switching to a non-restrictive satiating…
- Conditions
- Weight Loss, Weight Maintenance, Appetite Control
- Trial name
- NCT05141526
- Testing
- Non-restrictive satiating intervention, Conventional restrictive intervention + non-restrictive satiating intervention, Control group
- Where
- Canada
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Laval University
Atherosclerosis
Impact of Mild or Moderate Physical Activity and Progression of Subclinical Atherosclerosis
Subclinical atherosclerosis is identified in roughly 2/3rd of otherwise healthy young adults. How much physical activity is required to prevent progression of subclinical atherosclerosis? In the 85% of healthy younger Canadian…
- Trial name
- MoMA (NCT02628275)
- Testing
- Moderate to vigorous physical activity, Light physical activity
- Where
- Canada
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Laval University
Generalized Anxiety Disorder
Self-help Guided by Lay Providers for Anxiety in Older Adults
Few older adults receive treatment for Generalized Anxiety Disorder (GAD) despite a high prevalence in this population and significant associated health care costs.
- Trial name
- NCT03768544
- Testing
- Self-help guided by a lay provider, Waiting list where participants wait for delayed treatment
- Where
- 3 sites in Canada
- Volunteers
- 150 people
- Sponsor
- Laval University
Shoulder Pain
Psychosocial Factors of Persistent Shoulder Pain
Several studies have shown that in chronic pain conditions, factors such as lack of positivity and resilience, pain catastrophizing, stress, anxiety and depression can contribute to the persistence and maintenance of pain.
- Trial name
- NCT05328349
- Testing
- Education Program
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- Laval University
Healthy
Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults
Consumption of (poly)phenols is recognized to have beneficial effects on health. However, heterogeneous results are obtained in clinical trials due to high inter-individual variability.
- Trial name
- NCT05931237
- Testing
- Cranberry extract capsules
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Laval University
Type 1 Diabetes
Insulin Omission Surrogate (iOS)
Type 1 Diabetes management is requiring and implies numerous lifestyle modifications. Insulin restriction to control weight is a frequent phenomenon, affecting up to 40% of PWT1D.
- Trial name
- iOS (NCT05476861)
- Where
- Canada
- Volunteers
- 751 people
- Sponsor
- Laval University
Pulmonary Artery Hypertension
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH
Pulmonary arterial hypertension (PAH) is characterized by the progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure.
- Trial name
- NCT03979482
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Pulmonary Arterial Hypertension
Apabetalone for Pulmonary Arterial Hypertension
Throughout the past twenty years, numerous specific pharmacologic agents targeting the endothelial dysfunction associated with PAH have emerged.
- Trial name
- APPROACH-2 (NCT04915300)
- Testing
- Apabetalone
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Laval University
Endotoxemia, Metabolic Syndrome
Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health
The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity…
- Conditions
- Endotoxemia, Metabolic Syndrome, Glucose Metabolism Disorders, Insulin Resistance
- Trial name
- Phenulin (NCT03800277)
- Testing
- Cranberry, Agaves
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Laval University
Anticoagulant-induced Bleeding
DOAC Versus VKA After Cardiac Surgery
Postoperative management of oral anticoagulation is a frequent preoccupation in cardiac surgery, concerning about half of patients.
- Trial name
- DOAC/VKA (NCT04002011)
- Testing
- Warfarin, Dabigatran, Rivaroxaban
- Sponsor
- Laval University
ARDS, Human, Mechanical Ventilation Complication
Smartphone Application for Initiation of Protective Ventilation. Clinical Impact of Instrumental Dead Space Reduction
Clinical evaluation of a new educative tools (Smartphone application) based on impact of instrumental dead space reduction after initiation of protective ventilation during mechanical ventilation.
- Conditions
- ARDS, Human, Mechanical Ventilation Complication, Humidifier Lung
- Trial name
- Ventilo (NCT04390360)
- Testing
- Protective ventilation implementation, Protective ventilation with HME, Protective ventilation with Heated humidifier
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Cardiopulmonary Bypass, Obesity
Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery
Standard Heparin management, based on total body weight, is not well established for obese patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Trial name
- NCT03302195
- Testing
- Heparin, cardiopulmonary bypass pump flow rate
- Where
- Canada
- Volunteers
- 410 people
- Sponsor
- Laval University
Aortic Valve Stenosis, Cardiopulmonary Bypass
The Effect of Remote Ischemic Preconditioning in Aortic Valve Replacement Surgery
The study objective is to verify if a non-invasive remote ischemic preconditioning procedure (blood pressure cuff on the arm) is cardioprotective when applied before an aortic valve replacement surgery.
- Trial name
- NCT03305094
- Testing
- Blood pressure cuff inflation
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Laval University
Shoulder Pain, Rotator Cuff Injury
Does The Type of Exercise Influence Outcome in Rotator Cuff Related Shoulder Pain
Rotator cuff related shoulder pain (RCRSP) is the most common shoulder disorder and its chronicization leads to multiple consequences such as early retirement, absenteeism from work, decreased participation and quality of life…
- Conditions
- Shoulder Pain, Rotator Cuff Injury, Rotator Cuff Tendinitis, Rotator Cuff Impingement Syndrome
- Trial name
- RCT-RCRSP (NCT03892603)
- Testing
- Strengthening exercises program, Motor control exercises program, Education and advice
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Laval University