Clinical trials: sponsored by Lund University
Mycosis Fungoides, Sezary Syndrome
Predictive and Prognostic Biomarkers in Patients With Mycosis Fungoides and Sézary Syndrome.
A translational study for identification of prognostic and treatment-predictive biomarkers in Mycosis fungoides and Sézary syndrome.
- Trial name
- BIO-MUSE (NCT04904146)
- Testing
- Blood tests and testing of analysis of the lymphoma microenvironment in skin, skin barrier and skin microbiology profile.
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital
Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse (POP)
Effectiveness of Perineorrhaphy in Pelvic Organ Prolapse Surgery
This is an observational registry-based study of long-term outcome after vaginal native tissue repair for pelvic organ prolapse designed to emulate a pragmatic open-label two-arm trial for which patients, in whom perineorrhaphy…
- Trial name
- PINPOPS (NCT07006129)
- Testing
- Perineorrhaphy, No perineorrhaphy
- Where
- Sweden
- Volunteers
- 40,646 people
- Sponsor
- Lund University
Cesarean Birth
The Cesarean Study: Optimizing Cesarean Sections and Improving Patient-Healthcare Provider Trust Using Evidence Informed Recommendations
Cesarean section (CS) rates have rapidly increased worldwide, with projections suggesting that by 2030, one in every three births will be by CS (1).
- Trial name
- CS (NCT07759622)
- Testing
- Cesarean Bundle
- Where
- Sweden
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Lund University
Hand Osteoarthritis
Outcomes After First-line Treatment of Hand Osteoarthritis
This study will investigate outcomes of a 3-month first-line treatment program for hand osteoarthritis, using data from the Swedish Osteoarthritis Registry.
- Trial name
- NCT07708454
- Testing
- 3 months of exercise and education
- Volunteers
- 2,000 people
- Sponsor
- Lund University
Healthy Tissue, Muscles
Deep Optical Imaging of Tissue (DOIT)
In medical imaging, X-ray-based methods are widely used, which means that patients are exposed to ionizing radiation. In addition, invasive tissue samples often need to be taken with biopsy needles to, for example, safely…
- Conditions
- Healthy Tissue, Muscles, Extremity, Breast
- Trial name
- DOIT (NCT07754500)
- Testing
- Mk1
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
Borderline Personality Disorder, Self-harm
Effects of Psychiatric Admissions on Self-harm and Suicide in People With Borderline Personality Disorder
The current study aims to evaluate the impact of long (>5 days) and/or compulsory psychiatric inpatient care on subsequent healthcare utilization for self-harm and suicide in people with borderline personality disorder, a…
- Conditions
- Borderline Personality Disorder, Self-harm, Non-suicidal Self-injury, Suicide
- Trial name
- NCT06424509
- Testing
- High degree of long (>5 days) and/or compulsory psychiatric inpatient care
- Where
- Sweden
- Volunteers
- 390 people
- Sponsor
- Lund University
Plant-based Milk, Gastrointestinal Microbiome
Study the Effect of Plant-based Beverage Consumption on the Gut Microbiome in Healthy Adults
The goal of this intervention study is to analyse the microbiota composition after the plant-based beverage consumption. The main questions are to evaluate if the plant-based beverage can have a beneficial effect on the gut…
- Trial name
- NCT07730229
- Testing
- plant-based beverage
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
Heart Disease Congenital, Ventricular Septal Defect
Improving Care for Children With Congenital Heart Disease.
Establish a cardiovascular biomarker profile to help screening for congenital heart disease in infants and children as well as use non-invasive cardiac imaging in combination with such profiling to better predict the need for…
- Conditions
- Heart Disease Congenital, Ventricular Septal Defect, Atrial Septal Defect, Patent Ductus Arteriosus
- Trial name
- NCT04667455
- Testing
- Biomarker analysis at enrolment, Biomarker analyses throughout the study
- Where
- Sweden
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital
Chronic Pain, Analgesics, Opioid
Tapering From Long-term Opioid Therapy in Chronic Pain Population. Randomized Controlled Trial With 12 Months Follow up
This randomized controlled study compares tapering of long-term opioid therapy in a population with chronic non-cancer pain with control group constituted of waiting list.
- Conditions
- Chronic Pain, Analgesics, Opioid, Opioid Withdrawal, Opioid Use
- Trial name
- TOPIO (NCT03485430)
- Testing
- Tapering
- Where
- 3 sites in Sweden
- Volunteers
- 140 people
- Sponsor
- Lund University Hospital
Hip Pain Chronic
Long-term Follow up of Patients With Longstanding Hip and Groin Pain
In this longitudinal cohort study including young to middle aged people with longstanding hip and groin pain (LHGP) referred to tertiary care, we will collect data of patient reported symptoms, function and quality of life three…
- Trial name
- Lund LHGP (NCT03490071)
- Where
- Sweden
- Volunteers
- 58 people
- Sponsor
- Lund University
Athletic Injuries, Health Behavior
Implementing Injury Prevention Training in Youth Handball (I-PROTECT) Using the RE-AIM Evaluation Framework
The aim of this two-armed cluster-randomized controlled trial is to investigate the implementation of the I-PROTECT using the RE-AIM evaluation framework that addresses five dimensions of effectiveness and implementation of…
- Trial name
- I-PROTECT (NCT05696119)
- Testing
- I-PROTECT, Control
- Where
- Sweden
- Volunteers
- 4,225 people, healthy volunteers welcome
- Sponsor
- Lund University
Celiac Disease in Children, Autoimmune Diseases
Gluten Reduction and Risk of Celiac Disease
Celiac disease shares many features of other autoimmune diseases such as type 1 diabetes. Recently, it was published that higher amounts of gluten intake increased the risk for celiac disease.
- Conditions
- Celiac Disease in Children, Autoimmune Diseases, type1diabetes
- Trial name
- GRAIN (NCT04593888)
- Testing
- Gluten reduced diet
- Where
- Sweden
- Volunteers
- 1,141 people
- Sponsor
- Lund University
Celiac Disease in Children, Type 1 Diabetes
Prevention av Autoimmunitet Med Laktobaciller
The incidence of autoimmune diseases (celiac disease, type 1 diabetes, thyroid disease) have increased over the past 30 years. Although most autoimmune diseases have a strong link to different risk genes, the rapid increase is…
- Conditions
- Celiac Disease in Children, Type 1 Diabetes, Thyroid
- Trial name
- PAL (NCT04014660)
- Testing
- Probiotic
- Where
- Sweden
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Lund University
Type 1 Diabetes, Autoimmune Diabetes
Intensive Dietary and Activity Counselling (IDAC)
The aim of this intervention study is to investigate if a intensive dietary and physical activity counselling during the first two years of life in children with increased (genetically) risk for Type 1 Diabetes (T1D) can promote…
- Trial name
- IDAC (NCT06670625)
- Testing
- IDAC+
- Where
- Sweden
- Volunteers
- 1,244 people
- Sponsor
- Lund University
Preterm Birth, Pediatric Cancer
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
The overall aim is twofold: 1) to stretch the borderline regarding the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for facilitating and supporting self-management in families with long-term…
- Conditions
- Preterm Birth, Pediatric Cancer, Hirschsprung Disease, Congenital Malformation
- Trial name
- eChildHealth (NCT04150120)
- Testing
- e-health device with application, Mobile phone text messaging, early detection of cerebral palsy using a mobile phone application
- Where
- 7 sites in Denmark, Ethiopia and 1 more
- Volunteers
- 720 people
- Sponsor
- Lund University
URTI - Viral Upper Respiratory Tract Infection
Evaluation Viral RNA and Virus Infectivity in Exhaled Air Before and After Use of One Dose With ColdZyme Mouth Spray
Many respiratory diseases spread through aerosols. ColdZyme is a mouth spray that protects against upper respiratory tract viruses causing common cold and flu-like symptoms.
- Trial name
- NCT07041671
- Testing
- ColdZyme
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Hip Pain Chronic, Femoro Acetabular Impingement
Education and Exercise for Patients With Longstanding Hip and Groin Pain
Longstanding hip and groin pain (LHGP) is a common and debilitating problem in young to middle aged individuals. These patients often get referred to orthopedic departments.
- Conditions
- Hip Pain Chronic, Femoro Acetabular Impingement, Groin Injury
- Trial name
- HIPSTER (NCT05853640)
- Testing
- Usual care, HIPSTER
- Where
- Sweden
- Volunteers
- 122 people
- Sponsor
- Lund University
Mental Illness
UPSIDES - Recovery Through Peer Support
Research problem and specific questions Peer support (PS) is a well-established intervention within community mental health services (CMHS) internationally, involving a person recovering from serious mental health problems (SMHP)…
- Trial name
- NCT07407842
- Testing
- UPSIDES-Swe
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Lund University
ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Specific Phobia
Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders
The goal of this study is to develop a new internet-delivered cognitive behavioral therapy (ICBT) intervention for youths with anxiety disorders based on the best current knowledge about effective cognitive behavioral therapy for…
- Conditions
- ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Specific Phobia, Social Anxiety Disorder, Separation Anxiety Disorder
- Trial name
- NCT06661460
- Testing
- Internet-Delivered Cognitive Behavioral Therapy
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Lund University
Anxiety
Sensory Awareness Program
Few alternatives to addictive medical treatment exists for persons with severe mental health problems (SMHP) and anxiety, often connected to high risk of suicide.
- Trial name
- NCT06432114
- Testing
- Sensory Awareness Program (SAP), Treatment as usual (TAU)
- Where
- Sweden
- Volunteers
- 207 people
- Sponsor
- Lund University