Clinical trials: sponsored by Lund University
Labor Pain
Spinal Sufentanil for Obstetric Analgesia
Background: This descriptive study was designed to evaluate effects and adverse effects of spinal sufentanil for relief of labor pain in primi- and multiparous women.
- Trial name
- NCT04141527
- Testing
- Spinal analgesia
- Volunteers
- 164 people
- Sponsor
- Lund University
Locally Advanced Head and Neck Cancer
A Study of Cisplatin Plus Radiotherapy Compared to Cetuximab Plus Radiotherapy in Locally Advanced Head and Neck Cancer.
The primary endpoint in this study is to investigate if there is a difference in overall survival in patients with locally advanced head and neck cancer, randomized to either radiotherapy and cetuximab or radiotherapy and…
- Trial name
- ARTSCANIII (NCT01969877)
- Testing
- cetuximab, cisplatin
- Where
- 9 sites in Sweden
- Volunteers
- 298 people
- Sponsor
- Lund University Hospital
Chronic Low Back Pain, Chronic Sciatica
A Zhineng Qigong Intervention for Patients With Chronic Low Back Pain and/or Leg Pain
The purpose of this study is to evaluate a Zhineng Qigong intervention for patients with chronic low back pain and/or leg pain, and to test feasibility aspects.
- Conditions
- Chronic Low Back Pain, Chronic Sciatica, Lumbar Spinal Stenosis, Lumbar Disc Herniation
- Trial name
- NCT04520334
- Testing
- Zhineng Qigong intervention
- Where
- 9 sites in Sweden
- Volunteers
- 55 people
- Sponsor
- Lund University
Diet Prevention of Metabolic Diseases
Prebiotic Effects on Glucose Tolerance
The primary purpose of this project is to evaluate effects in healthy humans on glucose tolerance of cereal products with high amounts of fermentable dietary fibre.
- Trial name
- NCT03944343
- Testing
- Cereal based products
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Lund University
ACL Injury, Meniscus Lesion
Muscle Function and Traumatic Knee Injury in Sports
The aims of the project are to 1) evaluate different aspects of muscle function and its role as a potential risk and/or protective factor for traumatic knee injury in youth female athletes; 2) develop and evaluate a battery of…
- Conditions
- ACL Injury, Meniscus Lesion, Cartilage Injury, Ligament Injury
- Trial name
- NCT03479775
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University
Relapsed Prostate Cancer
Prospective Evaluation of 68-Ga-prostate Specific Membrane Antigen (PSMA)-Positron Emission Tomograph (PET) and Early Prostatic Specific Antigen (PSA) Kinetics During Salvage Radiotherapy for Personalizing the Management of Men With Relapse of Prostate Cancer After Radical Prostatectomy
This is an open-label, phase II trial in patients with PSA recurrence after prostatectomy. Patients entering the study will all receive initial 50 Gray (Gy) radiotherapy (25 x 2Gy) to the prostate bed and thereafter be classified…
- Trial name
- PROPER (NCT02699424)
- Testing
- External radiation therapy
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University Hospital
Metastatic Breast Cancer
Enumeration and Molecular Characterization of Circulating Tumour Cells in Women With Metastatic Breast Cancer
Women with metastatic breast cancer, receiving first line treatment of any kind (chemotherapy, endocrine treatment or treatment with antibodies) will be included in this trial.
- Trial name
- CTC-MBC (NCT01322893)
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Lund University Hospital
Obesity, Cardiovascular Risk Factor
Healthy Nordic Foods to Prevent Cardiometabolic Risk in Obese Subjects
This project will examine whether long-term consumption of healthy Nordic foods can maintain a healthy weight also after weight loss, and decrease abdominal fat accumulation and cardiometabolic risk.
- Conditions
- Obesity, Cardiovascular Risk Factor, Diet Modification
- Trial name
- NCT03102853
- Testing
- Nordic diet, Control diet
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lund University
Musculoskeletal Diseases or Conditions
Factors Related to the Number of Visits to PT in PHC
Musculoskeletal disorders can be a large burden on individuals, health care and social care systems. The aim was to assess the feasibility of performing a prospective study investigating whether self-efficacy, fear of movement…
- Trial name
- NCT04375007
- Testing
- Routine care
- Where
- Sweden
- Volunteers
- 19 people
- Sponsor
- Lund University
Postprandial Glucose Regulation
Health Effects of Oats and Oat Bioactive in Human
Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods.
- Trial name
- NCT03830736
- Testing
- Oat Beverage 1, Oat Beverage 2, Oat Beverage 3
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Lund University
Relapsed/Refractory Mantle Cell Lymphoma
A Trial of Ibrutinib, Lenalidomide and Rituximab for Patients With Relapsed/Refractory Mantle Cell Lymphoma
In this trial, patients with mantle cell lymphoma will be included, treatment with lenalidomide, rituximab and ibrutinib will be administered in an induction phase for up to 12 cycles, cycle length 28 days.
- Trial name
- PHILEMON (NCT02460276)
- Testing
- Lenalidomide, Ibrutinib, Rituximab
- Where
- 5 sites in Denmark, Finland and 2 more
- Volunteers
- 50 people
- Sponsor
- Lund University Hospital
Depression
Prevention of Depressive Relapse by Means of Physical Exercise and Lifestyle
Depression treatments including physical activity and sleep management has been shown to relieve depressive symptoms among participants suffering depressive episodes.
- Trial name
- NCT02599597
- Testing
- Therapist-assisted iCBT, Monthly screening with feedback
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lund University
Locally Advanced Cancer in the Anal Region
Phase I Study of Cetuximab in Combination With 5-fluoruracil, Mitomycin C and Radiotherapy in Patients With Anal Cancer Stage T2 (>4 cm) - T4 N0-3 M0 or Any T N2-3 M0
To establish maximum tolerated dose of the two cytotoxic drugs 5-fluoruracil and mitomycin C when given together with the antibody cetuximab in patients with locally advanced cancer in the anal region To evaluate acute toxicity…
- Trial name
- NOAC8 (NCT01621217)
- Testing
- Cetuximab, Mitomycin C, 5-Fluoruracil
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 21 people
- Sponsor
- Lund University Hospital
Adenocarcinoma of the Esophagus or Esophagogastric Junction
Palliative Short-course Hypofractionated Radiotherapy Followed by Chemotherapy in Adenocarcinoma of the Esophagus or Esophagogastric Junction Trial - a Phase II Clinical Trial Protocol.
In this trial, patients with histologically proven adenocarcinoma of the esophagus or esophagogastric junction noneligible for surgery or chemoradiation with curative intent will be included.
- Trial name
- PALAESTRA (NCT02241499)
- Testing
- Radiation therapy, Oxaliplatin and fluorouracil.
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Lund University Hospital
Prostate Cancer Recurrent
The Role of Follicle Stimulating Hormone in Advanced Prostate Cancer
In order to elucidate if FSH can have testosterone like effects, samples from young, non-smoking healthy volunteers, with normal body mass index, and with pharmacologically induced gonadotropin deficiency will be studied…
- Trial name
- NCT04134130
- Testing
- Degarelix 120 MG [Firmagon], Gonal F RFF Pen 900 UNT Per 1.5 ML Pen Injector, Testosterone Undecanoate
- Where
- Sweden
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Lund University
Type2 Diabetes
Diabetes Research on Patient Stratification
The overarching goal of the IMI DIRECT (Innovative Medicines Initiative Diabetes Research on Patient Stratification) Consortium is the identification of biomarkers that aid therapeutic targeting in prediabetes (Study 1) or early…
- Trial name
- DIRECT (NCT03814915)
- Volunteers
- 3,049 people
- Sponsor
- Lund University
Postprandial Glucose and Insulin Response
Postprandial Effect of High-starch Meals in Individuals With Low and High Copy Number of the Salivary Amylase Gene
Individuals with low copy numbers of salivary amylase gene have lower salivary amylase levels and might therefore have decreased capacity to metabolize starch into glucose.
- Trial name
- NCT03974126
- Testing
- 40 grams of starch, 80 grams of starch
- Where
- Sweden
- Volunteers
- 23 people
- Sponsor
- Lund University
Myocardial Infarction
Implementation and Assessment of a Life-style Focused Patient Support Application in Myocardial Infarction Patients
The study will assess the efficacy of a web-based application as a complement to traditional exercise-based cardiac rehabilitation for improvement of secondary prevention outcomes in post-myocardial infarction patients, compared…
- Trial name
- NCT03260582
- Testing
- LifePod®
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Lund University
Healthy
Metabolic Effects of Nopal in Healthy Humans
The overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people.
- Trial name
- NCT03831893
- Testing
- Nopal food product 1, Nopal food product 2, control
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Neuroendocrine Tumors, Liver Metastases
A Multicenter Study Evaluating Efficacy and Safety of 177Lu-DOTA-TATE Based on Kidney-Dosimetry in Patients With Disseminated Neuroendocrine Tumors
By improved kidney dosimetry including biological effective dose and taking into account potential risk factors (especially for kidney toxicity), it might be possible to give an optimal and personalized treatment with…
- Trial name
- ILUMINET (NCT01456078)
- Testing
- 177Lu-DOTA-TATE
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Lund University Hospital