Clinical trials: sponsored by Mansoura University
Dental Caries Class II, Marginal Integrity of Composite Restorations With Universal Adhesives
One-Step Universal Adhesives: A 3-year Clinical Trial in Class II Composite Restorations
to evaluate and compare the clinical performance and periodontal responses of four commercially available one-step universal adhesives with different formulations in Class II composite restorations over a three-year period.
- Trial name
- NCT06265116
- Testing
- One-step universal adhesive
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Prosthesis Durability
Vallecular Bolus Aggregation During Swallowing for Implant Overdenture.
evaluate the effect of implant retained mandibular overdenture on vallecular bolus aggregation during chewing and subsequent swallowing of solid food consistency.
- Trial name
- NCT06958055
- Testing
- videofluroscopy evaluation of swallowing function
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Implant Placement
Accuracy of Computer Guided Four Implants Placement in Completely Edentulous Mandible
Thirty-six completely edentulous healthy patients received four mandibular implants and were randomly divided into the following groups: (A) The implants were installed by fully guided stereolithographic stent (n = 18), and (B)…
- Trial name
- NCT06571968
- Testing
- fully guided stent, semiguided stent
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Nephrotic Syndrome
Effectiveness of Educational Gamified Cards About Nephrotic Syndrome
This study aims to evaluate the effectiveness of educational innovative gamified cards about nephrotic syndrome for school age children on their outcomes and caregivers' practices
- Trial name
- NCT05904197
- Testing
- Gamified Cards about Nephrotic Syndrome
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
SLE, Lupus Nephritis
Cardio Renal Effects of SGLT2 Inhibitors Among Lupus Nephritis Patients
This study aims to assess sodium glucose linked transoprter inhibitors(SGT2i) role in regression of ongoing kidney and cardiac diseases among lupus nephritis patient either diabetic or non-diabetic under different…
- Conditions
- SLE, Lupus Nephritis, SGLT2 Inhibitors
- Trial name
- NCT05748925
- Testing
- dapagliflozin
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Mansoura University
Refractory Ascites
Clinical Study to Evaluate the Efficacy and Safety of Dapagliflozin in Patients With Refractory Cirrhotic Ascites
The aim of this clinical trial is to evaluate the safety and efficacy of low dose dapagliflozin use along with standard care versus the standard care alone in improving the clinical outcomes of patients with cirrhotic refractory…
- Trial name
- NCT06919523
- Testing
- Dapagliflozin 5mg, Standard care treatment
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI)
Memantine as an Additive Therapy in Patients With Traumatic Brain Injury
Memantine has shown promise in mitigating secondary brain injury in previous studies. One study demonstrated that early memantine administration in moderate TBI patients resulted in lower serum neuron-specific enolase levels and…
- Trial name
- NCT06914310
- Testing
- Memantine, Mannitol
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Phenylketonuria
Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With Phenylketonuria
Effect of L-carnitine supplementation on phenylalanine and brain-derived neurotrophic factor levels in infants and children with phenylketonuria L-carnitine is mainly obtained from foods such as red meat and milk that are limited…
- Trial name
- NCT06901323
- Testing
- L-carnitine
- Where
- Egypt
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Chronic Kidney Disease(CKD), Anemia, Kidney Disease, Chronic
Impact of Dapagliflozin in Anemic Chronic Kidney Disease Patients
Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, primarily used in the management of type 2 diabetes mellitus.
- Trial name
- NCT06897605
- Testing
- Dapagliflozin (DAPA), Erythropoiesis Stimulating Agent
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
TBI Traumatic Brain Injury
Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury
Propranolol primarily acts as a non-selective beta blocker, blocking both beta-1 and beta-2 adrenergic receptors, while carvedilol exhibits a broader spectrum of action by also blocking alpha-1 adrenergic receptors.
- Trial name
- NCT06836856
- Testing
- control, propranolol, Carvedilol
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Virtual Plan of Mandibular Fracture
Three-Dimensional Printing and Three-Dimensional Miniplates in Treatment of Anterior Mandibular Fractures
The primary objective of this study was to evaluate the accuracy of virtual reduction and the prebending of the 3D miniplates on printed models for fixation of anterior mandibular fractures.
- Trial name
- NCT06898736
- Testing
- 3d miniplate
- Where
- 3 sites in Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Chronic Kidney Disease, Vascular Calcification
Pentoxifylline for Vascular Calcification in Kidney Disease
This study is research to find out if the drug pentoxifylline can help prevent or lessen the problem of blood vessel hardening (vascular calcification) in people with chronic kidney disease (CKD).
- Conditions
- Chronic Kidney Disease, Vascular Calcification, Kidney Failure, Chronic
- Trial name
- PTX-CALC-CKD (NCT06903689)
- Testing
- Pentoxifylline 400 MG Oral Tablet, Conventional Medications for Chronic Kidney Disease
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Chronic Kidney Disease, Bee Venom
Effect of Bee Venom on Chronic Kidney Disease-Mineral Bone Disorders in Hemodialysis Patients: a Randomized Controlled Trial
This study aims to evaluate the effectiveness of bee venom injections as a treatment for chronic kidney disease (CKD)-mineral bone disorder (MBD) in patients undergoing hemodialysis.
- Conditions
- Chronic Kidney Disease, Bee Venom, Hemodialysis
- Trial name
- BeeVenom-CKD (NCT06901102)
- Testing
- Bee Venom Injection, Standard Care for CKD-MBD
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Wound Healing, Anal Fistula
Platelet- Rich Plasma Injection
This randomized controlled study aims to investigate the effect of injection of platelet rich plasma on the postoperative outcome of perianal wound after anal fistula surgery in terms of healing time, reduction in wound size…
- Trial name
- prp (NCT06887166)
- Testing
- Platelet Rich Plasma
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Hemodialysis, Probiotics
Effect of Probiotic and Synbiotic Administration on Nutritional Status in Hemodialysis Patients
This study aims to investigate the impact of probiotics and synbiotics on the nutritional status of patients with end-stage kidney disease (ESRD) who are undergoing hemodialysis.
- Conditions
- Hemodialysis, Probiotics, Synbiotics, Nutritional Status
- Trial name
- ProSyn-HD (NCT06891105)
- Testing
- Lactogemikan (Probiotic Supplement), Lactogemikan + Prebiotic Fiber (Synbiotic Supplement)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Genetic Basis of COVID-19 Infection
Genetic and Immunologic Basis of COVID-19 Infection
We will study genetic factors causing severe disease due to infection with SARS-COV-2 which may help to find targeted therapy
- Trial name
- NCT04384250
- Testing
- Whole Exome Sequencing
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Mansoura University
Narrow-Angle Glaucoma
Combined VCST With Phacoemulsification Versus Phacoemulsification in Primary Angle Closure Glaucoma
As ab externo metal probe trabeculotomy cannot achieve 360-degree circumferential angle surgery, prolene suture can be used to achieve this without the need for an illuminated microcatheter.
- Trial name
- NCT06120621
- Testing
- Arm 1 : VCST-phaco group , Arm 2 : phaco group.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Voice and Voice Disorders
Effect of Intralesional Injection of Corticosteroids Combined with Hyaluronidase in Treatment of Minimal Associated Pathological Lesions of Vocal Folds, Participants and Condition: Patients with Benign Vocal Fold Lesions, Intervention: Intralesional Injection Via Working Channel of Nasofiberscope
Voice disorders encompass a wide range of pathologies that result in various degrees of voice impairment and decreased quality of life, Minimal Associated Pathological Lesions (MAPLs), include a group of non-malignant growths on…
- Trial name
- NCT06854380
- Testing
- Intralesional injection of steroids (betamethasone), (Betafos®) and hyaluronidase (enzyme), (Hynidase®) into benign vocal fold lesions by a naso-fiberscope with a side working channel(Storz 11001UD1)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Occlusal Analysis, Patient Satisfaction
3D Integration of Facial , Intraoral Scanning and CBCT on Patient Satisfaction and Occlusion of Temporary, Permanent Implant Supported Prosthesis
This study will aim to evaluate the effect of complete digital workflow for construction of temporary and permanent full arch implant supported screw retained restoration by the 3D integration of facial scanning, intraoral…
- Trial name
- NCT06846372
- Testing
- occluscence, patient satisfaction
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Odontogenic Cysts, Odontogenic Tumors
Evaluation of the Expression and Prognostic Role of Tumor Stem Cell Marker SOX2 in Odontogenic Cysts and Tumors
The pathogenesis of odontogenic lesions remains unclear; however, a probable explanation may involve the existence of tumor stem cells (TSCs), which are thought to generate both benign and malignant tumors.
- Trial name
- NCT06833840
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
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