Clinical trials: active, sponsored by Mansoura University
BPH (Benign Prostatic Hyperplasia)
Standard Versus Double Alpha Blockers Treatment for Symptomatic Benign Prostatic Obstruction
Failed medical treatment to alleviate LUTS and AUR is an indication for intervention, some trials were published elucidating the possible use of standard dose tamsulosin and silodosin and double dose tamsulosin but to the best of…
- Trial name
- NCT07815379
- Testing
- alpha blocker monotherapy Tamsulosin, alpha blockers Tamsulosin and Silodosin
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Mansoura University
Dental Implant Bone Loss, Peri-Implant Health
The Aim of the Study Will be Clinically and Radio Graphically Comparison of Two Implant Designs Used to Treat Atrophied Mandible . Implant Design Comparison Will Done for Implant Stability,Peri-implant Soft Tissue Health Changes and Bone Changes .Patients Will be Divided Randomly Into Two Group
The aim of the present study will be clinical and radio graphical comparison of four basal and compressive implant designs will be installed in the interforamina area of atrophied edentulous mandible and immediately loaded by bar…
- Trial name
- Implants types (NCT07588789)
- Testing
- Basal Dental implant, Compressive Dental implant
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Mansoura University
Postoperative Sore Throat, Nasal Obstruction
Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction
Postoperative sore throat (POST) affects 21-65% of patients after endotracheal intubation and is among the most common complaints after general anesthesia.
- Conditions
- Postoperative Sore Throat, Nasal Obstruction, Septoplasty
- Trial name
- POST-MUCOSAL R (NCT07870252)
- Testing
- Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube
- Where
- Saudi Arabia
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Premenstrual Syndrome
Integrated Core Stability Exercises and Yoga Program on Premenstrual Syndrome
This study aims to evaluate the effect of an integrated yoga and core stability exercises program on the severity of premenstrual syndrome symptoms and quality of life among nursing students.
- Trial name
- Exercise (NCT07889141)
- Testing
- exercises program
- Where
- 2 sites in Egypt
- Volunteers
- 92 people
- Sponsor
- Mansoura University
Obstructive Sleep Apnea
Effect of Transcutaneous Electrical Stimulation on Polysomnographic Parameters in Patients With Obstructive Sleep Apnea
The aim of this study is to assess the impact of transcutaneous electrical stimulation on polysomnographic findings in obstructive sleep apnea patients.
- Trial name
- NCT07891702
- Testing
- Transcutaneous Electrical Stimulation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Chewing Efficiency in Completely Edentulous Patients Rehabilitated With Implant-Supported Full-Arch Prostheses
Dynamic vs. Static Jaw Relations in Implant-Supported Prostheses: Chewing Efficiency
This study aims to compare the chewing efficiency of implant-supported full-arch prostheses fabricated using two different jaw relation registration techniques: conventional static jaw relation registration and dynamic jaw…
- Trial name
- NCT07890389
- Testing
- Conventional Static Jaw Relation Registration, Dynamic Digital Jaw Tracking Registration
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Noradrenaline
Prophylactic Norepinephrine for Prevention of Acute Kidney Injury in Living-Donor Liver Transplantation
goal-directed fluid therapy has demonstrated benefits on postoperative organ function, vasopressor support with norepinephrine is commonly employed to maintain perfusion pressure, though its renal impact in this setting remains…
- Trial name
- NE AKI in LDLT (NCT07885657)
- Testing
- Norepinephrine started prophylactically immediately post induction of general anesthesia, Norepinephrine infusion will only initiated if mean arterial pressure <65 mmHg despite preload optimization (stroke volume variation <12%) or if systemic vascular resistance <800 dynes•s/cm⁵
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Mansoura University
Class II Malocclusion
Maxillary Arch Distalization With Infrazygomatic Crest Miniscrews for Class II Malocclusion
This prospective clinical study will evaluate the effects of moving the entire upper dental arch backward using infrazygomatic crest miniscrews in participants with Class II malocclusion.
- Trial name
- NCT07875660
- Testing
- Infrazygomatic Crest Miniscrews
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Mansoura University
Hypersensitivity Dentin, Dental Restoration Failure of Marginal Integrity
Clinical Evaluation of Short Dentin Etching
To evaluate and compare the two-year clinical performance of Class I resin composite restorations utilizing a universal adhesive used in different etch-and-rinse strategies (15-second and 5-second etching) and self-etch…
- Trial name
- NCT06772051
- Testing
- Resin composite restoration bonded using universal adhesive in etch and rinse mode (15 seconds etching), Resin composite restoration bonded using universal adhesive in etch and rinse mode (5 seconds etching), Resin composite restoration bonded using universal adhesive in self-etch mode
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Respiratory Failure, Respiratory Failure With Hypercapnia
Role of HFNC During FOB in Patients With Respiratory Failure
This prospective interventional study aims to evaluate the safety and efficacy of high-flow nasal cannula (HFNC) oxygen therapy during fiber-optic bronchoscopy in patients with respiratory failure.
- Trial name
- NCT07880964
- Testing
- High flow nasal canula
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Erectile Dysfunction Due to Venous Disorder, Erectile Dysfunction (ED)
Embolosclerotherapy Versus Deep Dorsal Vein Revascularization in Venogenic Erectile Dysfunction
Venous leakage is one of the causes of erectile dysfunction and can be managed using different treatment modalities, including surgical ligation and percutaneous embolization.
- Trial name
- venogenic ED (NCT07604194)
- Testing
- Endovascular embolosclerotherapy, Revacularization of deep dorsal vein
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University Hospital
Muscle Relaxant
Small Doses Muscle Relaxant in General Anesthesia
This study will be held to assess the effect of minimal dose muscle relaxant on postoperative pulmonary function. The time to extubation in minutes will be the primary outcome as a clinical indicator of the return of muscle…
- Trial name
- relaxant (NCT04344262)
- Testing
- Atracurium Besylate regular dose, Atracurium Besylate minial dose
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
DIAPHRAGM -Ultrasound -Weaning -Mechanical Ventilation
Diaphragm Training Ultrasound
Common neurological indications of intubation and initiation of mechanical ventilation (MV) include ischemic and hemorrhagic stroke, neurotrauma, and intracranial hemorrhage.
- Trial name
- DiaphUS (NCT04186325)
- Testing
- DIAPHRAGMATIC exercising
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Postmenopausal Flushing, Postmenopausal Symptoms
Self-Management Box on Hot Flash in Postmenopausal Women
Aim of the study This study aims to evaluate the effect of a nurse-led menopause self-management box on hot flash frequency and menopause-specific quality of life among postmenopausal women.
- Trial name
- Self-Managemen (NCT07874893)
- Testing
- Components of Nurse-Led Menopause Self- Management Box
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Cardiac Anaesthesia, Cardiopulmonary Bypass
Comparison of Milrinone and Epinephrine on TAPSE
Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures.
- Trial name
- Milrinone (NCT07144267)
- Testing
- Epinephrine, Milrinone Injection
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Mansoura University
Dexmedetomidine Analgesia, Knee Surgery
Intravenous Regional Analgesia of Dexmedetomidine
Dexmedetomidine is a highly selective α₂-adrenergic receptor agonist that exerts its effects by inhibiting the release of norepinephrine at presynaptic nerve terminals, leading to reduced sympathetic activity; This mechanism…
- Trial name
- Dexmedetomidin (NCT07131579)
- Testing
- Normal Saline, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Fluid Balance
Caval Aorta Index for Fluid Optimization in Traumatic Brain Injury
Traumatic brain injury is a leading cause of death and disability in trauma patients. As the primary injury cannot be reversed; management strategies must focus on preventing secondary injury by avoiding hypotension and hypoxia…
- Trial name
- CAI for fluids (NCT06940258)
- Testing
- ultrasound measurement of caval aorta index, control group
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Mansoura University
Heart Failure
Finerenone Plus SGLT2 Inhibitors in Heart Failure
The goal of this clinical study is to evaluate whether adding finerenone to standard treatment with a sodium-glucose cotransporter-2 (SGLT2) inhibitor provides additional benefits in patients with heart failure.
- Trial name
- FIN-SGLT2-HF (NCT07351864)
- Testing
- Finerenone, dapagliflozine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Mandibular Fractures
Custom-Made Titanium Plates Versus Custom-Made Polyether Ether Ketone (PEEK) Plates
Mandibular fractures represent a significant portion of maxillofacial trauma, primarily resulting from motor vehicle accidents, interpersonal violence, and sports-related injuries.
- Trial name
- NCT07850570
- Testing
- Custom-Made Titanium Plate, Custom-Made PEEK Plate
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Mansoura University
Postpartum Hemorrhage, Uterine Atony
Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial
Background: Carbetocin is an established single-dose uterotonic agent for postpartum hemorrhage prophylaxis at elective cesarean delivery.
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Cesarean Section, Blood Loss, Surgical
- Trial name
- CARBOXY-RCT (NCT07636421)
- Testing
- Carbetocin, Oxytocin
- Where
- Saudi Arabia
- Volunteers
- 332 people
- Sponsor
- Mansoura University