Clinical trials: sponsored by Massachusetts General Hospital
Pancreatic Cancer
FOLFIRINOX + RT for Pancreatic Cancer
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of a therapy to learn whether the therapy works in treating a specific cancer.
- Trial name
- NCT01591733
- Testing
- FOLFIRINOX, Capecitabine, Short Course Radiation
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer Stage II, Breast Cancer Stage III
The Differential Impact of Proton Beam Irradiation Versus Conventional Radiation on Organs-at-risk in Stage II-III Breast Cancer Patients
The objective of the study is to serve as a correlative study for patients enrolled on the RadCOMP trial (NCT02603341), a randomized phase III study of stage II and III breast cancer patients treated with either conventional…
- Trial name
- NCT03270072
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Sleep, Circadian Rhythm
Dexmedetomidine Trial for Effects on Rhythms, Sleep Architecture, and Biomarker Dynamics in Older Adults
The DEXTER study is a cross-over, double-blind, placebo-controlled pilot research study led by Dr. Peng Li. The goal of this project is to evaluate the safety, feasibility, and biological effects of a single dose of sublingual…
- Trial name
- DEXTER (NCT07800910)
- Testing
- Dexmedetomidine sublingual film
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Refractory Epilepsy
Optimal Stimulation Parameters to Disrupt Epileptiform Activity
Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective…
- Trial name
- NCT06141668
- Testing
- Neurostimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Middle Aged
Text Messaging to Increase Activity in Midlife
This is a randomized controlled pilot trial of a text message intervention to promote physical activity in midlife adults (MASTERY), compared to an attention-matched control condition.
- Trial name
- MASTERY (NCT04849052)
- Testing
- MASTERY, Attentional Control
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease and Related Dementias, Quality of Life
Supporting Our Caregivers In ADRD Learning (SOCIAL)
Building on limitations of prior research, the investigators developed the Mindful and Self-Compassionate Care Program (MASC) to help caregivers of persons with Alzheimer Disease and Related Dementias (ADRD) manage stress…
- Conditions
- Alzheimer's Disease and Related Dementias, Quality of Life, Caregiver Stress
- Trial name
- SOCIAL (NCT06276023)
- Testing
- Mindful and Self-Compassionate Care Program (MASC), Health Education Program (HEP)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Waldenstrom Macroglobulinemia
Zanubrutinib, Bendamustine, Rituximab Prev. Untreated WM
The purpose of this study is to determine the very good partial response (VGPR) or better rate in participants with Waldenström macroglobulinemia (WM).
- Trial name
- ZEBRA (NCT06561347)
- Testing
- Zanubrutinib, Bendamustine, Rituximab
- Where
- 5 sites in United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Waldenstrom's Macroglobulinemia
Teclistamab In Waldenstrom's Macroglobulinemia
The goal of this clinical trial is to assess the efficacy of teclistamab in participants with relapsed or refractory Waldenstrom's macroglobulinemia who have received prior therapy.
- Trial name
- NCT07791498
- Testing
- Teclistamab
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Transthyretin Amyloidosis, Heart Failure
Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF
Recent studies have shown that transthyretin amyloidosis (ATTR) can sometimes cause a type of heart failure where the pumping function of the heart is normal, also known as Heart Failure with Preserved Ejection Fraction (HFpEF)…
- Conditions
- Transthyretin Amyloidosis, Heart Failure, Heart Failure, Diastolic, Amyloidosis
- Trial name
- TTRinHFpEF (NCT05577819)
- Testing
- 99mTc-pyrophosphate Scintigraphy
- Where
- United States
- Volunteers
- 515 people
- Sponsor
- Massachusetts General Hospital
Aortic Aneurysm
Ready for Recovery Pilot Trial
This is a three-arm, randomized pilot trial to examine the feasibility, acceptability, and preliminary efficacy of two multicomponent interventions to promote recovery from aortic aneurysm repair procedures.
- Trial name
- NCT07797504
- Testing
- Ready for Recovery, Enhanced Ready for Recovery
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Postoperative Delirium, Sleep
Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep
This study aims to determine whether, compared with placebo, the nighttime administration of a intravenous dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in extubated post-cardiac surgical…
- Conditions
- Postoperative Delirium, Sleep, Anesthesia
- Trial name
- MINDDS (NCT02856594)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV Prevention, HIV Preexposure Prophylaxis
Social Media as a Risk Tool for HIV Prevention Needs
The impact of effective HIV prevention tools is limited because many people do not know that they are at risk for HIV acquisition, despite the availability of various risk assessment scores and criteria.
- Trial name
- SMaaRT (NCT06566417)
- Where
- Kenya
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diabete Type 2, Pharmacogenomic Drug Interaction
PATHS-T2D: A Recall-by-Genotype Study of Physiologic and Pharmacologic Responses
This research study aims to learn about how the body responds to food through different genetic pathways and how these responses may change during a short course of orforglipron.
- Trial name
- PATHS-T2D (NCT07739537)
- Testing
- Orforglipron
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Refractory Multiple Myeloma, Relapse Multiple Myeloma
Elranatamab in R/R Multiple Myeloma
This research is being done to see if the study drug, elranatamab, reduces the risk of disease progression (worsening disease) after idecabtagene vicleucel in relapsed refractory multiple myeloma.
- Conditions
- Refractory Multiple Myeloma, Relapse Multiple Myeloma, Multiple Myeloma
- Trial name
- NCT06138275
- Testing
- Elranatamab
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may…
- Conditions
- Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Heart Failure, Right Sided, Heart Failure With Mid Range Ejection Fraction
- Trial name
- PREFER-HF (NCT03480633)
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder (MDD), Thiamine
Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents
The goal of this study is to examine the effectiveness of thiamine in reducing depressive symptoms in children and adolescents. The investigators hypothesize that thiamine administration will alleviate depressive symptoms in…
- Conditions
- Major Depressive Disorder (MDD), Thiamine, Vitamin B1, Thiamine Diphosphate (TDP)
- Trial name
- B1Ped (NCT07793071)
- Testing
- thiamine hydrochloride 100 mg
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Angiosarcoma, Epithelioid Hemangioendothelioma
Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE)
This research study is studying a drug as a possible treatment for Angiosarcoma or Epithelioid hemangioendothelioma (EHE). -The drug involved in this study is Eribulin
- Trial name
- NCT03331250
- Testing
- Eribulin
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Stomach Cancer Stage IV, Esophagus Cancer
Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA
This is a single arm, open-label, phase II trial investigating the combination of ivonescimab with standard FOLFOX chemotherapy in 1L therapy for HER2- GEA.
- Conditions
- Stomach Cancer Stage IV, Esophagus Cancer, Stomach Cancer
- Trial name
- NCT07070466
- Testing
- Ivonescimab, 5-Fluorouracil, Oxaliplatin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependance, Serious Mental Illness
Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking
The purpose of this study is to learn whether providing additional smoking cessation support through specially trained members of behavioral healthcare team helps people quit smoking and improve their health.
- Conditions
- Nicotine Dependance, Serious Mental Illness, Smoking (Tobacco) Addiction, Tobacco Cessation
- Trial name
- NCT07789132
- Testing
- Integrated CHW Support intervention, Enhanced usual care (EUC)
- Where
- United States
- Volunteers
- 937 people
- Sponsor
- Massachusetts General Hospital
Metastatic Melanoma, Skin Cancer
Cryoablation+Ipilimumab+Nivolumab in Melanoma
The aim of this study is to find out whether the combination of two approved drugs, ipilimumab and nivolumab, in combination with cryoablation are safe and effective for participants who have an unresectable melanoma that is…
- Trial name
- NCT05779423
- Testing
- Ipilimumab, Nivolumab, Cryoablation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.