Clinical trials: sponsored by Massachusetts General Hospital
Ascites, Liver Cirrhosis
Proximal Splenic Artery Embolization (PSAE) for the Treatment of Refractory Ascites in Decompensated Cirrhosis
The purpose of this study is to learn whether a procedure called Proximal Splenic Artery Embolization (PSAE) can lower the need for repeat fluid drainage in adults with cirrhosis and a buildup of fluid in the abdomen (ascites)…
- Conditions
- Ascites, Liver Cirrhosis, Hypertension, Portal
- Trial name
- NCT07755059
- Testing
- Proximal Splenic Artery Embolization
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Hip Pain Chronic, Hip Pain
HIPS Feasibility Randomized Controlled Trial
The goal of this clinical trial is to conduct a randomized controlled trial (RCT) to test the feasibility of two dose- and time-matched pain management programs, delivered via live video, for adults with chronic (lasting at least…
- Conditions
- Hip Pain Chronic, Hip Pain, Physical Medicine and Rehabilitation
- Trial name
- HIPS-RCT (NCT07586397)
- Testing
- HIPS-1, HIPS-2
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Sickle Cell Disease
Feasibility and Acceptability of Amani
Adults with sickle cell disease (SCD) experience severe pain, emotional distress, and social isolation that diminish their quality of life.
- Trial name
- Amani (NCT07648043)
- Testing
- Amani
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Brain Tumor
Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation
This research study is studying proton radiation as a possible treatment for brain tumor that requires radiation. The radiation involved in this study is: -Proton Radiation
- Trial name
- NCT03281889
- Testing
- Proton Beam
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Rolandic Epilepsy, Rolandic Epilepsy, Benign
Sleep Spindles and Memory in Rolandic Epilepsy
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI)…
- Conditions
- Rolandic Epilepsy, Rolandic Epilepsy, Benign, Centrotemporal Epilepsy, Centrotemporal; EEG Spikes, Epilepsy of Childhood
- Trial name
- NCT04569708
- Testing
- Closed loop auditory stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cervical Cancer Screening
Personalized Risk-based Follow-up of Cervical Cancer Screening in Practice, RCT
The goal of this PREDICT is to assess a personalize approach to screening and management of cervical cancer testing. The investigators will evaluate patients who are due for a follow up cervical cancer screening in the primary…
- Trial name
- PREDICT (NCT06872346)
- Testing
- Visit-based IT reminders to patients and practitioners, Population outreach
- Where
- United States
- Volunteers
- 7,500 people
- Sponsor
- Massachusetts General Hospital
Cholera
Single Dose Azithromycin to Prevent Cholera in Children
This study aims to determine whether single-dose azithromycin is effective in preventing cholera in children who are at extremely high risk of infection.
- Trial name
- NCT04326478
- Testing
- Azithromycin
- Where
- Bangladesh
- Volunteers
- 2,475 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
NASH - Nonalcoholic Steatohepatitis
Estrogen Administration for the Treatment of NASH in Postmenopausal Women
Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the United States. Despite this, the treatment options remain limited.
- Trial name
- NCT04833140
- Testing
- Estradiol patch
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Gout and Hyperuricemia
SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial
SAVE-Care (Sodium Glucose Cotransporter-2 inhibitors [SGLT2i] As Novel Gout Care) Trial is a double-blind randomized placebo-controlled trial (RCT) designed to assess the effect of empagliflozin on serum urate [SU] levels of gout…
- Trial name
- SAVE-Care (NCT06674109)
- Testing
- Empagliflozin 10 mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Pancreatic Cancer
Short Course Radiation Therapy With Proton or Photon Beam Capecitabine and Hydroxychloroquine for Resectable Pancreatic Cancer
A standard treatment for patients with pancreatic cancer is standard photon radiation in combination with the chemotherapy drug, capecitabine.
- Trial name
- NCT01494155
- Testing
- Capecitabine, Hydroxychloroquine, Proton or Photon Radiation Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
HIV-1-infection
Population Effectiveness of Dolutegravir Implementation in Sub-Saharan Africa
This is a prospective observational cohort study enrolling participants in South Africa and Uganda who are prescribed an HIV treatment regimen containing lamivudine, tenofovir, and dolutegravir, which is known as TLD.
- Trial name
- DISCO (NCT04066036)
- Testing
- This is an observational study only.
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 999 people
- Sponsor
- Massachusetts General Hospital
Suicidal Ideation, Suicidal Behavior
Multimodality Adaptive Intervention for Post-Inpatient Hospitalization Suicide Risk Reduction
The goal of this clinical trial is to learn whether a combination of brief digital and clinician-delivered interventions can help adults leaving a psychiatric hospitalization cope with suicidal thoughts and prevent…
- Trial name
- NCT06764108
- Testing
- Self-monitoring, JITAI, Self-guided SSI
- Volunteers
- 360 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Stepped Palliative Care Versus Early Integrated Palliative Care in Patients With Advanced Lung Cancer
This research study is evaluating ways to provide palliative care to patients who have recently been diagnosed with lung cancer
- Trial name
- STEP PC (NCT03337399)
- Testing
- Stepped PC, Early Integrated PC
- Where
- 3 sites in United States
- Volunteers
- 507 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain
Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance
Dual medication (guanfacine and morphine) as a standard treatment for chronic pain.
- Trial name
- NCT01681264
- Testing
- Morphine, Guanfacine 1mg, Guanfacine 2mg
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Massachusetts General Hospital
Multiple Myeloma
A Study of Dabrafenib and/or Trametinib in Patients With Relapsed and/or Refractory Multiple Myeloma
This research study is studying a targeted therapy as a possible treatment for multiple myeloma. The names of the study drugs involved in this study are: Trametinib Dabrafenib
- Trial name
- NCT03091257
- Testing
- Dabrafenib, Trametinib
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Retroperitoneal Sarcoma
Proton or Photon RT for Retroperitoneal Sarcomas
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for…
- Trial name
- NCT01659203
- Testing
- IG-IMPT, IG IMRT
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
ALS (Amyotrophic Lateral Sclerosis)
Trial of Oral Digoxin in Individuals With Amyotrophic Lateral Sclerosis (ALS)
This clinical trial is being conducted to learn about safety and tolerability of digoxin in ALS individuals. Additionally, this trial aims to better understand if digoxin has an effect on slowing neurodegeneration in ALS.
- Trial name
- ACACIA (NCT07047209)
- Testing
- Digoxin
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Massachusetts General Hospital
PTSD (Childbirth-Related)
Preventing Childbirth-Related PTSD With Expressive Writing
The goal of this clinical trial is to test a brief psychological intervention given to individuals in the first days following childbirth who have experienced a potentially stressful childbirth.
- Trial name
- CARES (NCT05662423)
- Testing
- Expressive Writing about Childbirth, Neutral Writing
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anorexia Nervosa, Atypical Anorexia Nervosa
Evaluation of a Twenty-session Cognitive-behavioral Therapy With Anorexia Nervosa (CBT-20-AN) Among Adults (18+)
The study is a clinical trial assessing the efficacy of a new twenty session cognitive behavioral therapy for adults (18+) with anorexia nervosa (AN) and atypical anorexia nervosa.
- Trial name
- NCT06597305
- Testing
- Twenty Session Cognitive-Behavioral Therapy for Anorexia Nervosa (CBT-20-AN)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Dyspnea, Lung Cancer (Diagnosis)
A Stepped Intervention for Coping With Dyspnea in Patients With Lung Cancer-Phase A (Open Pilot)
Patients with lung cancer often experience shortness of breath, also known as dyspnea. It affects over 80% of patients with lung cancer at diagnosis and is linked to poorer quality of life and functioning.
- Trial name
- INSPIRE (NCT07728773)
- Testing
- INSPIRE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.