Clinical trials: sponsored by Massachusetts General Hospital
Anorexia Nervosa, Atypical Anorexia Nervosa
Evaluation of a Twenty-session Cognitive-behavioral Therapy With Anorexia Nervosa (CBT-20-AN) Among Adults (18+)
The study is a clinical trial assessing the efficacy of a new twenty session cognitive behavioral therapy for adults (18+) with anorexia nervosa (AN) and atypical anorexia nervosa.
- Trial name
- NCT06597305
- Testing
- Twenty Session Cognitive-Behavioral Therapy for Anorexia Nervosa (CBT-20-AN)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Polycythemia Vera
Standardized Documentation and Assessments for Polycythemia Vera: A Quality Improvement Initiative
The purpose of this quality improvement initiative is to explore whether an electronic medical records-based templated progress note for polycythemia vera (PV) in addition to a standard-of-care pharmacist-collaborative…
- Trial name
- STANDARDIZE-PV (NCT07734272)
- Testing
- Standardized progress note
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Progressive Supranuclear Palsy, Parkinson Disease
Remote Monitoring in Progressive Supranuclear Palsy (PSP)
This is a single-arm, longitudinal, observational study on the use of wearable sensors and digital health technology to measure fall frequency and motor, speech, and cognitive function in patients with PSP over the course of…
- Conditions
- Progressive Supranuclear Palsy, Parkinson Disease, MSA - Multiple System Atrophy
- Trial name
- NCT04753320
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Massachusetts General Hospital
PDAC - Pancreatic Ductal Adenocarcinoma
PDAC-PATHWAYS: A Digital Informational and Supportive Care App for Patients Initiating Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma
This study aims to refine and pilot test PDAC-PATHWAYS, a digital informational and supportive care app for patients who are initiating neoadjuvant therapy for pancreatic ductal adenocarcinoma (PDAC).
- Trial name
- PDAC-PATHWAYS (NCT07047807)
- Testing
- PDAC-PATHWAYS, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
ALS, ALS (Amyotrophic Lateral Sclerosis)
Healey ALS MyMatch Common Screening Protocol
The goal of the Healey ALS MyMatch Common Screening Protocol (MCSP), an observational study, is to identify individuals with ALS who may be eligible to be matched to a currently enrolling ALS MyMatch trial.
- Conditions
- ALS, ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis
- Trial name
- MCSP (NCT07400393)
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Dyspnea, Lung Cancer (Diagnosis)
A Stepped Intervention for Coping With Dyspnea in Patients With Lung Cancer-Phase A (Open Pilot)
Patients with lung cancer often experience shortness of breath, also known as dyspnea. It affects over 80% of patients with lung cancer at diagnosis and is linked to poorer quality of life and functioning.
- Trial name
- INSPIRE (NCT07728773)
- Testing
- INSPIRE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Leukemia, Acute
Addressing Cancer Care Equity With Social Determinants of Health Screening and Early Intervention
The purpose of this study is to explore if screening health-related social needs and early social work consultation is feasible and acceptable for adults with leukemias.
- Trial name
- ACCESS (NCT07671209)
- Testing
- ACCESS-Leukemia
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Obesity
Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1 Therapy Discontinuation
This study will compare the effect of orforglipron and phentermine on weight maintenance.
- Trial name
- NCT07729332
- Testing
- Phentermine Pill, Orforglipron
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Ankle Fractures, Syndesmotic Injury
Biodegradable Magnesium Screws for Unstable Ankle Fracture Surgery
Ankle fractures are among the most common injuries that need surgery. When the broken bones make the ankle unstable, surgeons usually fix them with metal screws and plates.
- Trial name
- NCT07693933
- Testing
- RemeOs Magnesium-Based Biodegradable Screw
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation
Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF
The primary objective of this clinical investigation is to demonstrate the safety and 12-month effectiveness of pulmonary vein isolation (PVI) and posterior LA wall isolation in the treatment of subjects with symptomatic…
- Trial name
- POLARIS (NCT06099730)
- Testing
- Pulsed Field Ablation (PFA)
- Where
- 6 sites in United States
- Volunteers
- 442 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Depressive Episode
BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study
We propose to test the hypothesis that bezafibrate, a pan-PPAR agonist, may be effective and safe for bipolar depression with the following specific aims: Aim #1.
- Trial name
- NCT02481245
- Testing
- Bezafibrate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Bipolar Depression
A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression
The purpose of the Pilot Study Investigating the Efficacy of Minocycline and n-acetylcysteine for Bipolar Depression is to test the effectiveness of minocycline, n-acetylcysteine, and combined minocycline and n-acetylcysteine…
- Trial name
- NCT02719392
- Testing
- N-acetylcysteine, Minocycline
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Low-grade Glioma, IDH2 Gene Mutation
Niraparib In Recurrent IDH 1/2 Gliomas
This is a randomized, two-arm, open-label, phase 0 trial to assess intratumoral pharmacokinetics and pharmacodynamics of niraparib in subjects with progressive IDH1 or IDH2 mutant glioma.
- Conditions
- Low-grade Glioma, IDH2 Gene Mutation, Recurrent Glioma, IDH1 Mutation
- Trial name
- NCT05406700
- Testing
- Niraparib, Resection/Treatment with Niraparib
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Neurological Cancer
ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas
this research study is evaluating the highest dose of ASTX727 that can be administered safely to recurrent/progressive non-enhancing IDH mutant gliomas patients.
- Trial name
- NCT03922555
- Testing
- ASTX727
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Schwannomatosis, Schwannomas
Screening Trial for Pain Relief in Schwannomatosis (STARFISH)
This is a placebo-controlled, multi-arm phase II platform screening trial designed to test the safety, pain responses, and pharmacodynamic activity of multiple experimental therapies simultaneously in participants with…
- Conditions
- Schwannomatosis, Schwannomas, Pain, Chronic
- Trial name
- NCT05684692
- Testing
- Siltuximab, Erenumab-Aooe
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Treatment Resistant Depression (TRD)
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esketamine maintenance treatment in individuals with treatment-resistant…
- Trial name
- NCT07563868
- Testing
- Psychedelic Integration Coaching
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Pseudohypoparathyroidism Type 1a, Obesity
Setmelanotide to Treat Obesity in a Patient With Pseudohypoparathyroidism Type 1a (PHP1a)
The investigators plan to test the efficacy and safey of 6-months of open-label setmelanotide to treat obesity in a single patient with pseudohypoparathyroidism type 1a due to a GNAS mutation.
- Trial name
- NCT07496463
- Testing
- Setmelanotide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Cirrhosis, Insomnia
LiverSleep: A Behavioral Sleep Intervention for Patients With Cirrhosis and Insomnia
This is a pilot trial to test the feasibility and acceptability of a virtual cognitive behavioral program for insomnia for patients with cirrhosis.
- Trial name
- NCT07417163
- Testing
- Adapted Virtual Insomnia Program
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Suicidal Thoughts and Behaviors, Major Depressive Episode (MDE)
Biomarker Discovery for Suicide Precision Circuit Therapeutics
This is a prospective observational biomarker study assessing changes in clinical, behavioral, neuroimaging, and neurophysiological measurer following ketamine/esketamine or electroconvulsive therapy (ECT) in adults with suicidal…
- Trial name
- NCT07723066
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Maternal Death During Childbirth, Pregnancy Complications
Wireless Physiologic Monitoring in Postpartum Women
To estimate the clinical effectiveness of wireless physiologic monitoring of women in the first 24 hours after cesarean delivery at Mbarara Regional Referral Hospital
- Trial name
- WIMS (NCT04060667)
- Testing
- Wireless physiologic monitoring
- Where
- Uganda
- Volunteers
- 3,191 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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