Clinical trials: sponsored by Massachusetts General Hospital
Breast Cancer, Breast Abnormalities
Wearable Ultrasound Patch for Breast Imaging
The goal of this clinical trial is to learn if a wearable ultrasound (US) patch can provide reliable whole-breast imaging and accurately detect breast lesions in patients undergoing breast health evaluation.
- Conditions
- Breast Cancer, Breast Abnormalities, Breast Lesion, Breast Asymmetry
- Trial name
- NCT07186491
- Testing
- Wearable Ultrasound Patch
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hematologic Malignancy
Hospital at Home at EOL in Heme Malignancies
This study is evaluating an intervention, which the investigators call "Optimize End of Life (EOL) Care at Home," that entails remote patient monitoring and home-based supportive care for patients with advanced hematologic…
- Trial name
- NCT04690205
- Testing
- End of Life (EOL) Care at at Home
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Massachusetts General Hospital
Brain Metastases
Pembrolizumab In Central Nervous System Metastases
This research study is studying Pembrolizumab as a possible treatment for this diagnosis for metastases in the central nervous system (brain and spinal cord).
- Trial name
- NCT02886585
- Testing
- Pembrolizumab, MRI, PET/CT
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Massachusetts General Hospital
Pain
Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Pain
The aim of this proposal is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in healthy and patient populations to elucidate the…
- Trial name
- NCT03046030
- Testing
- Real acupuncture, VGAIT, VGAIT control
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Clear Cell Renal Cell Carcinoma (ccRCC), ccRCC
CAIX PET/CT for Residual or Recurrent Post-ablative ccRCC
The goal of this clinical trial is to learn whether 89Zr-Girentuximab PET scans can inform management of renal cell carcinoma. The main questions it aims to answer are: Does the 89Zr-Girentuximab PET detect ccRCC that is left…
- Trial name
- CAIX PET/CT (NCT07077083)
- Testing
- 89Zr-Girentuximab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain
Brain Mechanisms of Video-Guided Acupuncture Imagery Treatment on Chronic Low Back Pain
In this study, the investigators will examine the analgesic effects of acupuncture imagery treatment in patients with chronic low back pain.
- Trial name
- NCT03765879
- Testing
- Verum VGAIT (Video-Guided Acupuncture Imagery Treatment)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Metastatic Malignant Neoplasm to Brain, Recurrent Brain Metastases
Palbociclib and Pembrolizumab In Central Nervous System Metastases
This research study is studying This research study is studying the efficacy and safety of the following study drugs as a possible treatment for recurrent central nervous system (CNS) metastases: Palbociclib alone (Cohort 1) The…
- Conditions
- Metastatic Malignant Neoplasm to Brain, Recurrent Brain Metastases, Progressive Brain Metastases
- Trial name
- NCT02896335
- Testing
- Palbociclib, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Metastatic Cancer, Central Nervous System Cancer
Niraparib in Tumors Metastatic to the CNS
This research is being done to see how effective the drug niraparib is against cancer that has metastasized to the central nervous system (CNS). This research study involves the study drug niraparib.
- Trial name
- NCT04992013
- Testing
- Niraparib
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Wounds and Injury
Investigation of Laser Assisted Drug Delivery of NanoDOX®
This is a self-controlled single-site study of healthy subjects receiving an ablative fractional CO2 (carbon dioxide) laser procedure followed by topical application of NanoDOX® Hydrogel (1% doxycycline).
- Trial name
- NCT05411484
- Testing
- NanoDOX® Hydrogel, CO2 Ablative Fractional Laser
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Invasive Breast Cancer
Proton Radiation Therapy for Invasive Breast Cancer Following Mastectomy
In this study we are looking at a type of radiation called proton radiation which is known to spare surrounding tissue and organs from radiation.
- Trial name
- NCT01340495
- Testing
- Proton Radiation
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Liver Cancer, Hepatocellular Carcinoma
Pressure-enabled Delivery in Radioembolization (TriNav Study)
The purpose of the study is to determine if the type of catheter used in the mapping procedure prior to radioembolization improves the delivery of radioactivity to tumor(s) in participants with liver cancer.
- Conditions
- Liver Cancer, Hepatocellular Carcinoma, Metastatic Colorectal Cancer
- Trial name
- PEDIR (NCT05128032)
- Testing
- Standard microcatheter, PEDD device
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Knee Osteoarthritis
Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA
This study will combine brain imaging and neuromodulation tools to investigate the underlying neurobiological mechanisms of exercises.
- Trial name
- NCT05839535
- Testing
- BDJ, tDCS, exercise
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Massachusetts General Hospital
Experimental Pain, Low Back Pain
Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
This study aims to identify spatiotemporal alterations in thalamocortical circuitry functioning in both healthy subjects and patients with chronic pain, combining multimodal neuroimaging.
- Trial name
- NCT05763758
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Invasive Breast Cancer, Triple Negative Breast Cancer
Sacituzumab Govitecan In TNBC
This research study is studying to evaluate sacituzumab govitecan for individuals with localized triple negative breast cancer (TNBC) The names of the study drugs involved in this study is: Sacituzumab govitecan (SG)…
- Conditions
- Invasive Breast Cancer, Triple Negative Breast Cancer, ER-Negative Breast Cancer, PR-Negative Breast Cancer
- Trial name
- NeoSTAR (NCT04230109)
- Testing
- Sacituzumab Govitecan, Pembrolizumab
- Where
- 5 sites in United States
- Volunteers
- 239 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder
Auricular Transcutaneous Electrical Nerve Stimulation Treatment of Autism
In this study, investigators will examine the treatment effects of transcutaneous electrical nerve stimulation with different stimulation frequencies on individuals with autism.
- Trial name
- NCT03827941
- Testing
- 1 Hz Auricular transcutaneous electrical nerve stimulation, 20 Hz Auricular transcutaneous electrical nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Health Knowledge, Attitudes, Practices
The Science Tooth Fairy: A Randomized Trial of a Storytelling-Based Educational Intervention to Promote Primary Tooth Donation in a Pediatric Setting
Study Overview Primary ("baby") teeth are unique biological samples because they can permanently store information about a child's early life health and development.
- Trial name
- STF RCT (NCT07711301)
- Testing
- Science Tooth Fairy Narrative, Cavities vs. Toothpaste, book by Didi Dragon
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Impaired Cognition, Chemo-brain
Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.
- Conditions
- Impaired Cognition, Chemo-brain, Breast Cancer
- Trial name
- NCT02290834
- Testing
- Cognitive, functional and subjective assessments, MRI, PET Scan
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Psychosis, Schizophrenia
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental…
- Trial name
- NCT04940663
- Testing
- EMA
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cancer, Serious Mental Illness
Improving Care Delivery for Patients With Mental Illness and Cancer Across a Cancer Center Network
The proposed project is an implementation-effectiveness randomized trial of a person-centered collaborative care model for patients with serious mental illness and new cancer.
- Trial name
- BRIDGE-NET (NCT07707362)
- Testing
- BRIDGE NET
- Volunteers
- 248 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder
Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder
The objective of this study protocol is to test whether intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) can strengthen functional connectivity with a key region in…
- Trial name
- NCT06274567
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Massachusetts General Hospital
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