Clinical trials: sponsored by Massachusetts General Hospital
Neurofibromatosis 1
Tailoring an Online Platform to Promote Evidence-Based Care for Adults With Neurofibromatosis 1 and Low Health Literacy
This decentralized, randomized study seeks to assess the feasibility, acceptability, and preliminary effectiveness of two approaches to assisting Neurofibromatosis 1 (NF1) patients with low health literacy improve their…
- Trial name
- NCT07233408
- Testing
- NF1 Educational Videos, Peer Navigator, Letters about NF1 Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer (NSCLC), Lung Cancer Non-Small Cell Cancer (NSCLC)
Ivonescimab Alone And With Carboplatin/Pemetrexed For NSCLC
The goal of this clinical trial is to assess the efficacy of ivonescimab monotherapy in patients with advanced non-small cell lung cancer harboring actionable genomic alterations who have received prior targeted therapies and…
- Conditions
- Lung Cancer (NSCLC), Lung Cancer Non-Small Cell Cancer (NSCLC), Lung Cancer (Non-Small Cell), Lung Cancer - Non Small Cell
- Trial name
- NCT07405190
- Testing
- Ivonescimab, carboplatin, pemetrexed
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Massachusetts General Hospital
Anxiety Disorder of Childhood, Fear
Addressing Anxiety in 2-3-Year-Olds: A Pilot Intervention Study
The purpose of this study is to test the feasibility and efficacy of intervening with 2-year-old children with elevated temperamental Fear and/or Shyness or 3-year-old children with elevated anxiety and their parents, using a…
- Conditions
- Anxiety Disorder of Childhood, Fear, Shyness
- Trial name
- NCT04039243
- Testing
- Being Brave, Parent Education
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Parents
Resilient Families Feasibility Trial
The goal of this study is to test the feasibility and acceptability of a dyadic, resiliency intervention ("Resilient Families;" R-FAM) that aims to reduce emotional distress and improve relationships among parents in the Neonatal…
- Trial name
- R-FAM (NCT07383948)
- Testing
- Resilient Families (R-FAM), Educational Resources & Program
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pancreas Cancer
Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients With Pancreatic Cancer With Vascular Involvement
This research study is studying an intervention as a possible treatment for pancreatic cancer.
- Trial name
- PACER (NCT03716531)
- Testing
- IORT
- Where
- 6 sites in United States
- Volunteers
- 199 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer (Diagnosis)
Medically Tailored Meals to Reduce Ultra-processed Food Intake in Colorectal Cancer Survivors
This research study is a three-arm, parallel-group randomized clinical trial that examines the feasibility and initial impact of consuming medically tailored meals to reduce intake of ultra-processed food and improve health and…
- Trial name
- MTM (NCT07701707)
- Testing
- MTM: Medically tailored meals, MTM plus Fresh Produce, Control group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Episode, Borderline Personality Disorder
Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics
This neuroimaging study is a clinical trial investigating the effectiveness of intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) in reducing suicide risk in patients with…
- Conditions
- Major Depressive Episode, Borderline Personality Disorder, Suicide
- Trial name
- NCT04130958
- Testing
- Intermittent Theta Burst Transcranial Magnetic Stimulation (Active)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Study to Evaluate Sacituzumab Govitecan in Combination With Talazoparib in Patients With Metastatic Breast Cancer.
This research is studying the effect of Antibody-Drug Conjugate Sacituzumab Govitecan in Combination with the Poly (Adenosine Diphosphate [ADP]-Ribose) Polymerase (PARP) Inhibitor Talazoparib in Patients with Metastatic…
- Trial name
- NCT04039230
- Testing
- Talazoparib, Sacituzumab Govitecan
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Parents
Resilient Families Open Pilot: Dyadic Resiliency Intervention
The goal is to develop, refine, and test the feasibility and acceptability of a dyadic, resiliency intervention ("Resilient Families;" R-FAM) that aims to reduce emotional distress and improve relationships among parents in the…
- Trial name
- R-FAM (NCT06239571)
- Testing
- Resilient Families (R-FAM)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Multiple Sclerosis
Effects of Antiviral Therapies on Epstein-Barr Virus Replication
This research study is being performed to find out if Truvada (tenofovir/emtricitabine), an antiviral drug with activity against the Epstein Barr virus (EBV), can reduce EBV levels in saliva and blood in people with multiple…
- Trial name
- NCT05957913
- Testing
- Truvada (tenofovir/emtricitabine)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Mild Cognitive Impairment
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or…
- Trial name
- NCT05904132
- Testing
- tACS device
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Suicidal Ideation, Suicide Attempt
A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior
This study aims to evaluate the acceptability, safety, and efficacy of a smartphone-delivered intervention called Therapeutic Evaluative Conditioning for Suicide (TEC-S) in reducing suicidal thoughts and behaviors (STB) among…
- Trial name
- NCT06686901
- Testing
- Smartphone-delivered Therapeutic Evaluative Conditioning for Suicide (TEC-S), Smartphone-delivered inactive Therapeutic Evaluative Conditioning
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Exploring the Efficacy and Feasibility of the LymphaTech Scanner for Breast Cancer-Related Lymphedema Screening
This research will compare the absolute volumes of the upper extremity using both the LymphaTech Scanner and Perometer in a cohort of patients with a history of invasive or in-situ carcinoma of the breast.
- Trial name
- NCT03861975
- Testing
- Breast Cancer-Related Lymphedema Measurements
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Normal Physiology
Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms
The goal of this clinical trial is to learn how the pupil responds to different light stimuli and how that relates to sleep and daily rhythms in healthy people of different ages.
- Trial name
- NCT05829044
- Testing
- Pupillometry, Light box exposure
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypertension, Diabetes
Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the >30% of pregnant people who have or are at risk for…
- Conditions
- Hypertension, Diabetes, Postpartum, Pregnancy
- Trial name
- NCT06557005
- Testing
- Facilitated Transition to Primary Care
- Where
- United States
- Volunteers
- 1,320 people
- Sponsor
- Massachusetts General Hospital
Subjective Cognitive Decline, Depression in Old Age
Developing a Peer Support Intervention for Depression in SCD
The purpose of this study is to assess the feasibility, acceptability, and fidelity of an 8-week intervention where peer coaches will deliver depression care to adults 60 years of age or older who have depression and subjective…
- Trial name
- NCT06358404
- Testing
- PeersCOG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Lymphedema, Lymphedema Arm
Screening For BCRL In Targeted Therapy For Breast Cancer
This a prospective, longitudinal study designed to track edema and Breast Cancer Related Lymphedema (BCRL) onset in breast cancer patients taking targeted therapy treatments for early and metastatic breast cancer.
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Upper Arm, Lymphedema of Upper Limb
- Trial name
- NCT05142800
- Testing
- Perometer, SOZO device
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Breast Cancer Treatment Related Lymphedema
Early Intervention
This research study is a Pilot Study examining the use of a compression sleeve with embedded sensor to prevent lymphedema.
- Trial name
- NCT05326165
- Testing
- Juzo Compression Sleeve and Glove, Compression Sleeve Sensor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Mobile Application to Improve Health-Related Outcomes in Patients With Advanced Lung Cancer
Multi-site randomized trial of the THRIVE digital health application versus usual care to evaluate the effect of THRIVE on quality of life (QOL), physical and psychological symptoms, coping, and self-efficacy in 250 patients with…
- Trial name
- THRIVE (NCT06427954)
- Testing
- Digital Health App
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Left Bundle Branch Area Pacing
The Boston Pace Study
Right ventricular (RV) pacing can cause left ventricular systolic dysfunction in 10- 20% of patients. Biventricular pacing had previously been shown to prevent left ventricular systolic dysfunction.
- Trial name
- NCT05869500
- Testing
- Left Bundle Branch Area Pacemaker, Right Ventricular Pacemaker
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
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